ID Q03UM1_LEUMM Unreviewed; 357 AA.
AC Q03UM1;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:ABJ63101.1};
DE EC=1.1.1.85 {ECO:0000313|EMBL:ABJ63101.1};
GN OrderedLocusNames=LEUM_2031 {ECO:0000313|EMBL:ABJ63101.1};
OS Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM
OS 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB
OS 8023 / NCTC 12954 / NRRL B-1118 / 37Y).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=203120 {ECO:0000313|EMBL:ABJ63101.1, ECO:0000313|Proteomes:UP000000362};
RN [1] {ECO:0000313|EMBL:ABJ63101.1, ECO:0000313|Proteomes:UP000000362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO
RC 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y
RC {ECO:0000313|Proteomes:UP000000362};
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P.,
RA Kozyavkin S., Weimer B., Mills D.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|RuleBase:RU004443}.
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DR EMBL; CP000414; ABJ63101.1; -; Genomic_DNA.
DR RefSeq; WP_011680545.1; NC_008531.1.
DR AlphaFoldDB; Q03UM1; -.
DR EnsemblBacteria; ABJ63101; ABJ63101; LEUM_2031.
DR GeneID; 61177560; -.
DR KEGG; lme:LEUM_2031; -.
DR eggNOG; COG0473; Bacteria.
DR HOGENOM; CLU_031953_0_3_9; -.
DR Proteomes; UP000000362; Chromosome.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR004429; Isopropylmalate_DH.
DR NCBIfam; TIGR00169; leuB; 1.
DR PANTHER; PTHR42979; 3-ISOPROPYLMALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR42979:SF1; 3-ISOPROPYLMALATE DEHYDROGENASE; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004443}.
FT DOMAIN 6..344
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 357 AA; 39173 MW; AF5C61B7223DB277 CRC64;
MTSVKKIVVL KGDYIGPEIM TAGLAVLDAA TKDTTFAYEL IDAPFGGDGI DRAGDPLPQS
TIDVSKQADA VLLSAIGGPK WDNAPRRPEQ GLLEIRSKLN LFANIRPTKV TAAQIDRSPL
KPEYVENTDF VIVRELTSGA YFGKPRKLEA HQAIDTMYYS EEEVTRIMHQ GFKMAQKRNK
HVTIVDKSNV LATSKFWRKI ANEVGKSYQD VTIDYYYVDA MTMAIMAKPT TFDVVIIPNL
FGDILSDEAA QITGSIGQIP SMSVGESGPN LYEPIHGSAP DIAGQGIANP ISMVNTVAMM
LTESFDEKRI ADKITAAVDY IIENHCVTPD MGGTMTTDEV TQKMVDYIKN YESADIK
//
