ID Q04EJ8_OENOB Unreviewed; 898 AA.
AC Q04EJ8;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN OrderedLocusNames=OEOE_1248 {ECO:0000313|EMBL:ABJ57124.1};
OS Oenococcus oeni (strain ATCC BAA-331 / PSU-1).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Oenococcus.
OX NCBI_TaxID=203123 {ECO:0000313|EMBL:ABJ57124.1, ECO:0000313|Proteomes:UP000000774};
RN [1] {ECO:0000313|EMBL:ABJ57124.1, ECO:0000313|Proteomes:UP000000774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-331 / PSU-1 {ECO:0000313|Proteomes:UP000000774};
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P.,
RA Kozyavkin S., Weimer B., Mills D.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
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DR EMBL; CP000411; ABJ57124.1; -; Genomic_DNA.
DR RefSeq; WP_002823421.1; NC_008528.1.
DR AlphaFoldDB; Q04EJ8; -.
DR STRING; 203123.OEOE_1248; -.
DR DNASU; 4415350; -.
DR KEGG; ooe:OEOE_1248; -.
DR PATRIC; fig|203123.7.peg.1259; -.
DR eggNOG; COG1012; Bacteria.
DR eggNOG; COG1454; Bacteria.
DR HOGENOM; CLU_007207_1_0_9; -.
DR Proteomes; UP000000774; Chromosome.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000000774}.
FT DOMAIN 14..293
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 477..890
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 898 AA; 99100 MW; 09B947B36B6267DC CRC64;
MAVETKKITK KILTSDELKD KKETAKKYIG ELVDKSRQAL LEFSQYSQSQ VDKIVAAMAL
AGSEHSLELA HFARNETGRG VVEDKDTKNR FASESVYNTI KNDKTVGVID EDPITGKVQL
AAPLGILAGI VPTTNPTSTT IFKSLLTAKT RNTIIFAFHP QAQKSSVAAA KIVYQAARKA
GAPKDFIQWI ETPSLENTTA LMQNPEIASI LATGGPSMVH AALTSGNPSM GVGAGNGAVF
IDHTARVRRA AEDLLLSKRF DNGMICATEN SAVIEASVYD EFMKLMQEKG TYLVPKDDYK
KIADFVFSDK HAVNGPVAGM SGRWIAEHAG VTLPKGKDVL LFELDQDDIG EKLSSEKLSP
LLSVYKAADR KEAIKVVQRL LNYQGAGHNA AIQIGAQDDP FVKEYADAVS ASRILVNQPD
SIGGVGDIYT DALRPSMTLG TGSWGKNSLS HNLSTYDLLN VKTVARRRNR PQWVRLPKDI
YYEKNAITYL QELPNVNRAF VITDHSLVKY GFVDRILEQF ELRPDQVKTS IYSSVQPDPY
LSQAVEIAKQ MQEFEPDTVI ALGGGSSLDV AKISRFLYEY SQEPDHIGFL ENIDDIKELF
KGLQQKFMDI RKRIVKFEHQ NLTQLVAIPT TSGTGSEVTP FSVITDDETH VKYPLADYEL
TPQVAIVDPE LVMTVPKRTL AWSGLDALSH SLESYVSVMS SEFTRPWALQ AIKLIFENIV
DSYNYDPKHP TNRGAEAREK MHYAATLAGM SFGNAFLGIN HSLAHKTGGE FGLPHGLAIS
IAMPHVIRFN AVTGNVKRTP FPRYEVYTAQ KDYADIARHI GLSGKNDAEL VEKLIAKIKE
LTDALDVNIT LSGNGVDKKS FEHSLDQLVD LVYDDQCTPG NPRQPNLAEI RQLLIDQF
//
