ID Q04PC9_LEPBJ Unreviewed; 560 AA.
AC Q04PC9;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Sulfite reductase (NADPH), alpha subunit {ECO:0000313|EMBL:ABJ77241.1};
GN Name=cysI {ECO:0000313|EMBL:ABJ77241.1};
GN OrderedLocusNames=LBJ_2837 {ECO:0000313|EMBL:ABJ77241.1};
OS Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=355277 {ECO:0000313|EMBL:ABJ77241.1, ECO:0000313|Proteomes:UP000000656};
RN [1] {ECO:0000313|EMBL:ABJ77241.1, ECO:0000313|Proteomes:UP000000656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB197 {ECO:0000313|EMBL:ABJ77241.1,
RC ECO:0000313|Proteomes:UP000000656};
RX PubMed=16973745; DOI=10.1073/pnas.0603979103;
RA Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A.,
RA Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L.,
RA Rood J.I., Davies J.K., Adler B.;
RT "Genome reduction in Leptospira borgpetersenii reflects limited
RT transmission potential.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- COFACTOR:
CC Name=siroheme; Xref=ChEBI:CHEBI:60052;
CC Evidence={ECO:0000256|ARBA:ARBA00001929};
CC -!- SIMILARITY: Belongs to the nitrite and sulfite reductase 4Fe-4S domain
CC family. {ECO:0000256|ARBA:ARBA00010429}.
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DR EMBL; CP000350; ABJ77241.1; -; Genomic_DNA.
DR RefSeq; WP_011672097.1; NC_008510.1.
DR AlphaFoldDB; Q04PC9; -.
DR KEGG; lbj:LBJ_2837; -.
DR HOGENOM; CLU_001975_3_2_12; -.
DR Proteomes; UP000000656; Chromosome 1.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.480.20; -; 1.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 2.
DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR InterPro; IPR036136; Nit/Sulf_reduc_fer-like_dom_sf.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045169; NO2/SO3_Rdtase_4Fe4S_prot.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR PANTHER; PTHR11493:SF47; SULFITE REDUCTASE [NADPH] SUBUNIT BETA; 1.
DR PANTHER; PTHR11493; SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED; 1.
DR Pfam; PF01077; NIR_SIR; 2.
DR Pfam; PF03460; NIR_SIR_ferr; 2.
DR PRINTS; PR00397; SIROHAEM.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 2.
DR SUPFAM; SSF55124; Nitrite/Sulfite reductase N-terminal domain-like; 2.
DR PROSITE; PS00365; NIR_SIR; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 65..130
FT /note="Nitrite/Sulfite reductase ferredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF03460"
FT DOMAIN 164..321
FT /note="Nitrite/sulphite reductase 4Fe-4S"
FT /evidence="ECO:0000259|Pfam:PF01077"
FT DOMAIN 342..408
FT /note="Nitrite/Sulfite reductase ferredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF03460"
FT DOMAIN 462..557
FT /note="Nitrite/sulphite reductase 4Fe-4S"
FT /evidence="ECO:0000259|Pfam:PF01077"
SQ SEQUENCE 560 AA; 62548 MW; 7958DE6C1FCB7905 CRC64;
MSETKELSPV EEIKLNSRNL RGKIAEGLDR NIDSYEEDEK QLLKFHGLYQ QKDRDRKKDE
SGNDMEAPTS FMIRGRIPGG RLTPEQYLVW DELGDKFGGG AIRLTTRQSV QLHTLRIFHL
RDVMKAIHEV NLSSMGACGD VVRNVTQAVN PLGKKELQLL DGVSQILSDH FKYKTNAYAE
VWLGDKQLNK DEEETIYGKT YLPRKFKIAV TLAGNNTVDI YANDMGFAAT LSANGKIDGY
FVFAGGGFGM THNKPETFAR AASLLGWIPE SALIPVAEAI VTAHRDFGDR TNRKHARLKY
VLAEKGVDWF RSEVESRSNV KLDTDKSLPS WKTPSYLGWN EREDGTLSLG FHTLAGRIKD
FPGRPLKSAL REIIGIYKLH VQITADQDLI LIGIQKSDRE KIEKRLQELN VPWKSPSPLY
DRALACPALP TCALALTESE RSFPEVLNGI QKVLDKLGLG DRALVVRMTG CPNGCARPYS
AEVGIVGQQA GGKYSLFFGA DSEGTKVGEY VAKKVALADI PAQLEKVFVL WKEEGDSDEK
FGDFVNRFPL ERFREVLGSM
//
