ID   Q06120_PVMA             Unreviewed;       789 AA.
AC   Q06120;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE   Flags: Fragment;
GN   Name=polyprotein {ECO:0000313|EMBL:AAB24779.1};
OS   Potato virus A (PVA).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC   Patatavirales; Potyviridae; Potyvirus.
OX   NCBI_TaxID=12215 {ECO:0000313|EMBL:AAB24779.1};
OH   NCBI_TaxID=45843; Solanum betaceum (Tamarillo) (Cyphomandra betacea).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1] {ECO:0000313|EMBL:AAB24779.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8418789; DOI=10.1007/BF01309794;
RA   Collins R.F., Leclerc D., AbouHaidar M.G.;
RT   "Cloning and nucleotide sequence of the capsid protein and the nuclear
RT   inclusion protein (NIb) of potato virus A.";
RL   Arch. Virol. 128:135-142(1993).
CC   -!- FUNCTION: Involved in aphid transmission, cell-to-cell and systemis
CC       movement, encapsidation of the viral RNA and in the regulation of viral
CC       RNA amplification. {ECO:0000256|ARBA:ARBA00029405}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC   -!- SIMILARITY: Belongs to the potyviridae genome polyprotein family.
CC       {ECO:0000256|ARBA:ARBA00006064, ECO:0000256|RuleBase:RU003351}.
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DR   EMBL; S51667; AAB24779.1; -; Genomic_RNA.
DR   PIR; A48337; A48337.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   CDD; cd23175; ps-ssRNAv_Potyviridae_RdRp; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001592; Poty_coat.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF00767; Poty_coat; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   DOMAIN          246..370
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50507"
FT   REGION          527..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..547
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         789
FT                   /evidence="ECO:0000313|EMBL:AAB24779.1"
SQ   SEQUENCE   789 AA;  89514 MW;  802D4F1EABA72189 CRC64;
     VYTQGCDSKW LFNAAHTNIQ AVAQLESNLV TKHTVKGKCK LFETYLNVDK AAHDFFSKYM
     GFYKPSKLNR EAYTQDLMKY SKVIQVGEVD CEVFESALTG LLRNLGRWGF TTACYTTDED
     SIYAALNMKA AVGALYRGKK RDYFDAMSPS EKEHLLFLSC KRLYFGQLGV WNGSLKAELR
     PKEKVDLNKT RTFTAAPIET LLGGKVCVDD FNNMFYSLHL KAPWSVGMTK FYGTWNQLMC
     KLPDDWVYCD ADGSQFDSSI SPYMINAVLR IRLHFMEDWD IGSQMLQNLN TEIVYTPIST
     PDGTVVKKFK GNNSGQPSTV VDNTLLVVLA MHYALLKSGV PLEEQDSVCV YCVNGDDLLI
     AIRPDMEHKL DGFQALFSEL GLNYEFNSRS KDKKDLWFMS HKAIQCGEIL IPKLEEERIV
     SILEWDRSHE PIHRLEAICA SMVESWGYPE LTHEIRRFYA WVLEQSPYNA LATTGLAPYI
     AESALKTLYT NVHPTSTELE KYSIQFDEQM DEEDDMVYFQ AGTLDAGETP AQKSEGKKKE
     GEGNSGKAVA VKDKDVDLGT AGTHSVPRLK SMTSKLTLPM LKGKSVVNLD HLLSYKPKQV
     DLSNARATHE QFQNWYDGVM ASYELEESSM EIILNGFMVW CIENGTSPDI NGVWTMMDNE
     EQVSYPLKPM LDHAKPSLRQ IMRHFSALAE AYIEMRSREK PYMPRYGLQR NLRDQSLARY
     AFDFYEITAT TPVRAKEAHL QMKAAALKNS NTNMFGLDGN VTTSEEDTER HTATDVNRNM
     HHLLGVKGV
//