ID Q06900_CHICK Unreviewed; 503 AA.
AC Q06900;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 2.
DT 27-MAR-2024, entry version 183.
DE RecName: Full=TGF-beta receptor type-1 {ECO:0000256|ARBA:ARBA00040150};
DE EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
DE AltName: Full=Transforming growth factor-beta receptor type I {ECO:0000256|ARBA:ARBA00043075};
GN Name=ChALK5 {ECO:0000313|EMBL:BAA03357.2};
GN Synonyms=TGFBR1 {ECO:0000313|Ensembl:ENSGALP00010010506.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:BAA03357.2};
RN [1] {ECO:0000313|EMBL:BAA03357.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8219284;
RA Nohno T., Sumitomo S., Ishikawa T., Ando C., Nishida S., Noji S., Saito T.;
RT "Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase
RT of the TGF-beta receptor family.";
RL DNA Seq. 3:393-396(1993).
RN [2] {ECO:0000313|EMBL:BAA03357.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10885742; DOI=10.1006/dbio.2000.9698;
RA Lai Y.T., Beason K.B., Brames G.P., Desgrosellier J.S., Cleggett M.C.,
RA Shaw M.V., Brown C.B., Barnett J.V.;
RT "Activin receptor-like kinase 2 can mediate atrioventricular cushion
RT transformation.";
RL Dev. Biol. 222:1-11(2000).
RN [3] {ECO:0000313|Ensembl:ENSGALP00010010506.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010010506.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-
CC seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022,
CC Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
CC EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023945};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-
CC L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-
CC COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
CC ChEBI:CHEBI:456216; EC=2.7.11.30;
CC Evidence={ECO:0000256|ARBA:ARBA00023948};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251}. Cell surface
CC {ECO:0000256|ARBA:ARBA00004241}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. TGFB receptor subfamily.
CC {ECO:0000256|ARBA:ARBA00009605}.
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DR EMBL; D14460; BAA03357.2; -; mRNA.
DR PIR; A56693; A56693.
DR RefSeq; NP_989577.1; NM_204246.1.
DR IntAct; Q06900; 1.
DR STRING; 9031.ENSGALP00000054311; -.
DR PaxDb; 9031-ENSGALP00000020569; -.
DR Ensembl; ENSGALT00010018957.1; ENSGALP00010010506.1; ENSGALG00010007951.1.
DR GeneID; 374094; -.
DR KEGG; gga:374094; -.
DR CTD; 7046; -.
DR VEuPathDB; HostDB:geneid_374094; -.
DR eggNOG; KOG2052; Eukaryota.
DR GeneTree; ENSGT00940000156394; -.
DR HOGENOM; CLU_000288_8_1_1; -.
DR OMA; VPHCCDK; -.
DR OrthoDB; 3900892at2759; -.
DR TreeFam; TF314724; -.
DR Reactome; R-GGA-2173788; Downregulation of TGF-beta receptor signaling.
DR Reactome; R-GGA-2173789; TGF-beta receptor signaling activates SMADs.
DR Reactome; R-GGA-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
DR Reactome; R-GGA-5689880; Ub-specific processing proteases.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000033179; Expressed in spermatocyte and 13 other cell types or tissues.
DR GO; GO:0048179; C:activin receptor complex; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; ISA:AgBase.
DR GO; GO:0009986; C:cell surface; ISA:AgBase.
DR GO; GO:0005768; C:endosome; ISA:AgBase.
DR GO; GO:0016020; C:membrane; IDA:AgBase.
DR GO; GO:0045121; C:membrane raft; ISA:AgBase.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; ISA:AgBase.
DR GO; GO:0043235; C:receptor complex; ISA:AgBase.
DR GO; GO:0070021; C:transforming growth factor beta ligand-receptor complex; IEA:Ensembl.
DR GO; GO:0048185; F:activin binding; IBA:GO_Central.
DR GO; GO:0016361; F:activin receptor activity, type I; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; ISA:AgBase.
DR GO; GO:0019838; F:growth factor binding; ISA:AgBase.
DR GO; GO:0070411; F:I-SMAD binding; ISA:AgBase.
DR GO; GO:0004672; F:protein kinase activity; ISA:AgBase.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISA:AgBase.
DR GO; GO:0046332; F:SMAD binding; ISA:AgBase.
DR GO; GO:0050431; F:transforming growth factor beta binding; IDA:AgBase.
DR GO; GO:0005024; F:transforming growth factor beta receptor activity; ISA:AgBase.
DR GO; GO:0005025; F:transforming growth factor beta receptor activity, type I; IDA:AgBase.
DR GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISA:AgBase.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0032924; P:activin receptor signaling pathway; IDA:AgBase.
DR GO; GO:0001525; P:angiogenesis; ISA:AgBase.
DR GO; GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; ISS:AgBase.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISA:AgBase.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0048844; P:artery morphogenesis; ISA:AgBase.
DR GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:AgBase.
DR GO; GO:0048870; P:cell motility; ISA:AgBase.
DR GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISA:AgBase.
DR GO; GO:0030199; P:collagen fibril organization; ISA:AgBase.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISA:AgBase.
DR GO; GO:0042118; P:endothelial cell activation; IMP:AgBase.
DR GO; GO:0043542; P:endothelial cell migration; ISA:AgBase.
DR GO; GO:1905223; P:epicardium morphogenesis; ISS:AgBase.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; ISA:AgBase.
DR GO; GO:0008354; P:germ cell migration; ISA:AgBase.
DR GO; GO:0007507; P:heart development; IDA:AgBase.
DR GO; GO:0035556; P:intracellular signal transduction; IDA:AgBase.
DR GO; GO:0001822; P:kidney development; ISA:AgBase.
DR GO; GO:0002088; P:lens development in camera-type eye; ISA:AgBase.
DR GO; GO:0008584; P:male gonad development; ISA:AgBase.
DR GO; GO:0048762; P:mesenchymal cell differentiation; IMP:AgBase.
DR GO; GO:0036446; P:myofibroblast differentiation; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISA:AgBase.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; ISA:AgBase.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISA:AgBase.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISA:AgBase.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0048663; P:neuron fate commitment; ISA:AgBase.
DR GO; GO:0060017; P:parathyroid gland development; ISA:AgBase.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; ISA:AgBase.
DR GO; GO:0018107; P:peptidyl-threonine phosphorylation; ISA:AgBase.
DR GO; GO:0060037; P:pharyngeal system development; ISA:AgBase.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISA:AgBase.
DR GO; GO:0030307; P:positive regulation of cell growth; ISA:AgBase.
DR GO; GO:0030335; P:positive regulation of cell migration; ISA:AgBase.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISA:AgBase.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:AgBase.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:AgBase.
DR GO; GO:1901203; P:positive regulation of extracellular matrix assembly; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; ISA:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
DR GO; GO:1902462; P:positive regulation of mesenchymal stem cell proliferation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; ISA:AgBase.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISA:AgBase.
DR GO; GO:1904018; P:positive regulation of vasculature development; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; ISA:AgBase.
DR GO; GO:0006468; P:protein phosphorylation; ISA:AgBase.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; ISA:AgBase.
DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; IMP:AgBase.
DR GO; GO:0010468; P:regulation of gene expression; IMP:AgBase.
DR GO; GO:0043393; P:regulation of protein binding; ISA:AgBase.
DR GO; GO:0031396; P:regulation of protein ubiquitination; ISA:AgBase.
DR GO; GO:0070723; P:response to cholesterol; ISA:AgBase.
DR GO; GO:0060021; P:roof of mouth development; ISA:AgBase.
DR GO; GO:0007165; P:signal transduction; ISA:AgBase.
DR GO; GO:0001501; P:skeletal system development; ISA:AgBase.
DR GO; GO:0048705; P:skeletal system morphogenesis; ISA:AgBase.
DR GO; GO:0048538; P:thymus development; ISA:AgBase.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:AgBase.
DR CDD; cd14143; STKc_TGFbR1_ACVR1b_ACVR1c; 1.
DR Gene3D; 2.10.60.10; CD59; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000472; Activin_recp.
DR InterPro; IPR003605; GS_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR000333; TGFB_receptor.
DR PANTHER; PTHR23255:SF61; TGF-BETA RECEPTOR TYPE-1; 1.
DR PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR Pfam; PF01064; Activin_recp; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08515; TGF_beta_GS; 1.
DR SMART; SM00467; GS; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS51256; GS; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Kinase {ECO:0000313|EMBL:BAA03357.2}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:BAA03357.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transferase {ECO:0000256|ARBA:ARBA00022527};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..503
FT /note="TGF-beta receptor type-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014306685"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..204
FT /note="GS"
FT /evidence="ECO:0000259|PROSITE:PS51256"
FT DOMAIN 205..495
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 232
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 503 AA; 56509 MW; 87E16F45C5B0F837 CRC64;
MALRGTRRLR ALLRLLVAAV LLPRAAALQC YCHLCTKDNF TCVTDGLCFT SVTRTADRVI
RNSMCIAEID LIPRDRPFIC APSFRDGVTT LPHCCDRDHC NKIELPIPTP GPTPGRPASS
LGPVELAAVI AGPVCFVCIS LMLILYLCHN RTVIHHRVPS EEDPSLDRPF ISEGTTLKDL
IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER
SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS
ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI
HEDYQLPYYD LVPSDPSVEE MKKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA
ARLTALRIKK TLSQLSQQEG IKM
//
