ID Q06XS9_COILA Unreviewed; 379 AA.
AC Q06XS9;
DT 31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Alcohol dehydrogenase 1 {ECO:0000256|ARBA:ARBA00041139};
DE EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190};
OS Coix lacryma-jobi (Job's tears).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Rottboelliinae; Coix.
OX NCBI_TaxID=4505 {ECO:0000313|EMBL:ABE68381.2};
RN [1] {ECO:0000313|EMBL:ABE68381.2}
RP NUCLEOTIDE SEQUENCE.
RA Wu G., Li Y., Chen D.;
RT "Molecular cloning, nucleotide sequencing and expression of cDNA encoding
RT alcohol dehydrogenases from Coix lacryma-jobi L. during waterlogging.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABE68381.2}
RP NUCLEOTIDE SEQUENCE.
RA Chen D., Zhu Y., Li Y.;
RT "Molecular cloning and prokaryotic expression of alcohol dehydrogenases
RT cDNA from Coix.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABE68381.2}
RP NUCLEOTIDE SEQUENCE.
RA Chen D., Zhu Y., Li Y.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001146};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000781};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; DQ455071; ABE68381.2; -; mRNA.
DR AlphaFoldDB; Q06XS9; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08301; alcohol_DH_plants; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF40; ALCOHOL DEHYDROGENASE 1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 36..121
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 205..337
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 379 AA; 40965 MW; 4E265A2599F8A7C9 CRC64;
MATAGKVIKC RAAVAWEASK PLSIEEVEVA PPQAMEVHVK ILFTSLCHTD VYFWEAKGQT
PVFPRIFGHE AGGIVESVGE GVTDLAPGDH VLPVFTGECK ECAHCKSAES NMCDLLRINT
DRGVMIGDGK SRFSINGKPI YHFVGTSTFS EYSVMHVGCV AKINPEAPLD KVCVLSCGIS
TGLGASINVA KPPKGSTVAI FGLGAVGLAA AEGARIAGAS RIIGIDLNPN RFEEAKKFGC
TEFVNPKDHN KPAQEVLAEM TNGGVDRSVE CTGNIHAMIQ AFECVHDGWG VAVLVGVPHK
DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT HSVPFAEINK
AFDLMAKGEG IRCIIRMEN
//