ID SOS2_HUMAN Reviewed; 1332 AA.
AC Q07890; D3DSB4; Q15503; Q17RN1;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 29-MAY-2013, entry version 118.
DE RecName: Full=Son of sevenless homolog 2;
DE Short=SOS-2;
GN Name=SOS2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8493579; DOI=10.1126/science.8493579;
RA Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H.,
RA Bar-Sagi D.;
RT "Human Sos1: a guanine nucleotide exchange factor for Ras that binds
RT to GRB2.";
RL Science 260:1338-1343(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296.
RC TISSUE=Placenta;
RA Fath I., Apiou F., Dutrillaux B., Tocque B.;
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes the exchange of Ras-bound GDP by GTP (By
CC similarity).
CC -!- INTERACTION:
CC P00519:ABL1; NbExp=2; IntAct=EBI-298181, EBI-375543;
CC P46108:CRK; NbExp=2; IntAct=EBI-298181, EBI-886;
CC P62993:GRB2; NbExp=6; IntAct=EBI-298181, EBI-401755;
CC P16333:NCK1; NbExp=3; IntAct=EBI-298181, EBI-389883;
CC Q9UKS6:PACSIN3; NbExp=2; IntAct=EBI-298181, EBI-77926;
CC P19174:PLCG1; NbExp=4; IntAct=EBI-298181, EBI-79387;
CC Q9Y5X1:SNX9; NbExp=2; IntAct=EBI-298181, EBI-77848;
CC -!- SIMILARITY: Contains 1 DH (DBL-homology) domain.
CC -!- SIMILARITY: Contains 1 N-terminal Ras-GEF domain.
CC -!- SIMILARITY: Contains 1 PH domain.
CC -!- SIMILARITY: Contains 1 Ras-GEF domain.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Son of sevenless entry;
CC URL="http://en.wikipedia.org/wiki/Son_of_Sevenless";
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DR EMBL; L13858; AAA35914.1; -; mRNA.
DR EMBL; CH471078; EAW65727.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW65728.1; -; Genomic_DNA.
DR EMBL; BC117261; AAI17262.1; -; mRNA.
DR EMBL; L20686; AAA91852.1; -; mRNA.
DR IPI; IPI00020134; -.
DR RefSeq; NP_008870.2; NM_006939.2.
DR UniGene; Hs.291533; -.
DR ProteinModelPortal; Q07890; -.
DR IntAct; Q07890; 14.
DR MINT; MINT-1782446; -.
DR STRING; 9606.ENSP00000216373; -.
DR PhosphoSite; Q07890; -.
DR DMDM; 223634694; -.
DR PaxDb; Q07890; -.
DR PRIDE; Q07890; -.
DR DNASU; 6655; -.
DR Ensembl; ENST00000216373; ENSP00000216373; ENSG00000100485.
DR GeneID; 6655; -.
DR KEGG; hsa:6655; -.
DR UCSC; uc001wxs.4; human.
DR CTD; 6655; -.
DR GeneCards; GC14M050583; -.
DR H-InvDB; HIX0037776; -.
DR HGNC; HGNC:11188; SOS2.
DR HPA; CAB004577; -.
DR MIM; 601247; gene.
DR neXtProt; NX_Q07890; -.
DR PharmGKB; PA36025; -.
DR eggNOG; NOG265981; -.
DR HOGENOM; HOG000013040; -.
DR HOVERGEN; HBG017831; -.
DR InParanoid; Q07890; -.
DR KO; K03099; -.
DR OMA; QKTFPHP; -.
DR OrthoDB; EOG470TGG; -.
DR PhylomeDB; Q07890; -.
DR Reactome; REACT_111045; Developmental Biology.
DR Reactome; REACT_111102; Signal Transduction.
DR ChiTaRS; SOS2; human.
DR GenomeRNAi; 6655; -.
DR NextBio; 25943; -.
DR ArrayExpress; Q07890; -.
DR Bgee; Q07890; -.
DR CleanEx; HS_SOS2; -.
DR Genevestigator; Q07890; -.
DR GermOnline; ENSG00000100485; Homo sapiens.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; NAS:UniProtKB.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
DR GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_core_D.
DR InterPro; IPR011993; PH_like_dom.
DR InterPro; IPR001849; Pleckstrin_homology.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR008937; Ras_GEF.
DR InterPro; IPR023578; Ras_GEF_dom.
DR InterPro; IPR001895; RasGRF_CDC25.
DR InterPro; IPR015759; Sos.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR PANTHER; PTHR23113:SF47; PTHR23113:SF47; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DH-domain; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF48366; Ras_GEF; 1.
DR PROSITE; PS00741; DH_1; FALSE_NEG.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Guanine-nucleotide releasing factor; Polymorphism;
KW Reference proteome.
FT CHAIN 1 1332 Son of sevenless homolog 2.
FT /FTId=PRO_0000068896.
FT DOMAIN 198 388 DH.
FT DOMAIN 442 546 PH.
FT DOMAIN 595 739 N-terminal Ras-GEF.
FT DOMAIN 778 1017 Ras-GEF.
FT COMPBIAS 755 758 Poly-Pro.
FT COMPBIAS 1180 1183 Poly-Pro.
FT COMPBIAS 1203 1208 Poly-Pro.
FT VARIANT 483 483 S -> N (in dbSNP:rs17122201).
FT /FTId=VAR_054327.
FT VARIANT 508 508 H -> Y (in dbSNP:rs8010237).
FT /FTId=VAR_054328.
FT VARIANT 672 672 L -> I (in dbSNP:rs34139502).
FT /FTId=VAR_034441.
FT CONFLICT 32 32 E -> V (in Ref. 1; AAA35914).
FT CONFLICT 192 192 S -> C (in Ref. 1; AAA35914).
FT CONFLICT 239 240 DI -> VY (in Ref. 1; AAA35914).
FT CONFLICT 381 381 L -> H (in Ref. 1; AAA35914).
FT CONFLICT 482 482 S -> T (in Ref. 1; AAA35914).
FT CONFLICT 687 687 I -> V (in Ref. 1; AAA35914).
FT CONFLICT 696 696 E -> D (in Ref. 1; AAA35914).
FT CONFLICT 699 699 F -> Y (in Ref. 1; AAA35914).
FT CONFLICT 778 778 H -> D (in Ref. 1; AAA35914).
FT CONFLICT 861 861 Q -> R (in Ref. 4; AAA91852).
FT CONFLICT 948 948 K -> R (in Ref. 1; AAA35914).
FT CONFLICT 999 999 S -> C (in Ref. 4; AAA91852).
FT CONFLICT 1032 1032 S -> E (in Ref. 4; AAA91852).
FT CONFLICT 1042 1042 T -> A (in Ref. 4; AAA91852).
FT CONFLICT 1112 1114 CGS -> LC (in Ref. 4; AAA91852).
FT CONFLICT 1159 1159 A -> G (in Ref. 4; AAA91852).
FT CONFLICT 1296 1296 Q -> E (in Ref. 4; AAA91852).
SQ SEQUENCE 1332 AA; 152979 MW; 0D1D4FAB8E37C371 CRC64;
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC
MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK VLMDMFDQDD
IGLVSLCEDE PSSSGELNYY DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI
EKIFSNISDI HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH YFELLKQLKA
CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD PVCPFYSHQL RSKHLAIKKM
NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR IGAKHERHIF LFDGLMISCK PNHGQTRLPG
YSSAEYRLKE KFVMRKIQIC DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI
SLHYRSTLDR MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE PEPTDADKLA
IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY DFERDLELLE RLESFISSVR
GKAMKKWVES IAKIIRRKKQ AQANGVSHNI TFESPPPPIE WHISKPGQFE TFDLMTLHPI
EIARQLTLLE SDLYRKVQPS ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA
ENFEERVAVL SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG KDLINFSKRR
KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE KEFTDYLFNK SLEIEPRNCK
QPPRFPRKST FSLKSPGIRP NTGRHGSTSG TLRGHPTPLE REPCKISFSR IAETELESTV
SAPTSPNTPS TPPVSASSDL SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS
EEPLIPPPLP PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR DISTCPNSPS
TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP HLPKLPPKTY KRELSHPPLY
RLPLLENAET PQ
//
