ID   BTR_BORPE               Reviewed;         242 AA.
AC   Q08530;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 2.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Transcriptional regulatory protein btr;
GN   Name=btr; OrderedLocusNames=BP1197;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BP504;
RX   PubMed=7693656; DOI=10.1128/jb.175.22.7228-7235.1993;
RA   Bannan J.D., Moran M.J., Macinnnes J.I., Soltes G.A., Friedman R.L.;
RT   "Cloning and characterization of btr, a Bordetella pertussis gene encoding
RT   an FNR-like transcriptional regulator.";
RL   J. Bacteriol. 175:7228-7235(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: May regulate gene expression in response to changes in oxygen
CC       levels or to changes in the redox potential of the bacterial
CC       environment.
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DR   EMBL; L20602; AAC36850.1; -; Unassigned_DNA.
DR   EMBL; BX640414; CAE41493.1; -; Genomic_DNA.
DR   PIR; A49926; A49926.
DR   RefSeq; NP_879971.1; NC_002929.2.
DR   RefSeq; WP_010930241.1; NZ_CP039022.1.
DR   AlphaFoldDB; Q08530; -.
DR   SMR; Q08530; -.
DR   STRING; 257313.BP1197; -.
DR   PaxDb; 257313-BP1197; -.
DR   GeneID; 69601110; -.
DR   KEGG; bpe:BP1197; -.
DR   PATRIC; fig|257313.5.peg.1289; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_075053_0_2_4; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00092; HTH_CRP; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR24567; CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR24567:SF75; FUMARATE AND NITRATE REDUCTION REGULATORY PROTEIN; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   PRINTS; PR00034; HTHCRP.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..242
FT                   /note="Transcriptional regulatory protein btr"
FT                   /id="PRO_0000100143"
FT   DOMAIN          158..231
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        191..210
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   CONFLICT        27..64
FT                   /note="GMPANEVEKLDELVKERVRVERGKTLYELDDPLDAVYG -> ACLPTKSRNW
FT                   TNSSRRPCAWSAAKRSTNSTIPWSRLR (in Ref. 1; AAC36850)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="D -> V (in Ref. 1; AAC36850)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174..187
FT                   /note="RYAALGYSSTEFVL -> ATRRSAIRRPNSCV (in Ref. 1;
FT                   AAC36850)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="R -> A (in Ref. 1; AAC36850)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   242 AA;  27130 MW;  CD07103C2AFDAC12 CRC64;
     MQRRVPLSPD AAHCSSCMLG HVCVPVGMPA NEVEKLDELV KERVRVERGK TLYELDDPLD
     AVYGVRFGSL KTQLEDSSGQ LQITGFHLPG EIVGLDGMIE SKHVSSAVAL EDSEVCVIRL
     PEIDRVSTQL PSLQQQFRRL MSREITRSHQ MLATVGAMRS EQRLAAFLLN LSQRYAALGY
     SSTEFVLRMS REEIGNYLGL TLETVSRLFS RFGREGLIRI NQREVRLIDL PGLKQLIGQE
     SC
//