ID Q08E34_BOVIN Unreviewed; 609 AA.
AC Q08E34;
DT 31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=Translocase of outer mitochondrial membrane 70 {ECO:0000313|EMBL:AAI23445.1, ECO:0000313|EMBL:ADK26451.1, ECO:0000313|Ensembl:ENSBTAP00000019001.5};
GN Name=TOMM70 {ECO:0000313|Ensembl:ENSBTAP00000019001.5,
GN ECO:0000313|VGNC:VGNC:49582};
GN Synonyms=Tom70 {ECO:0000313|EMBL:ADK26451.1}, TOMM70A
GN {ECO:0000313|EMBL:AAI23445.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI23445.1};
RN [1] {ECO:0000313|EMBL:AAI23445.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI23445.1};
RC TISSUE=Thalamus {ECO:0000313|EMBL:AAI23445.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADK26451.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Heart {ECO:0000313|EMBL:ADK26451.1};
RA Stutz S., Schwarz H., Linke D., Nussberger S.;
RT "Purification of native TOM complex from the outer membrane of bovine heart
RT mitochondria.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000019001.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000019001.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000019001.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000019001.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004572}.
CC -!- SIMILARITY: Belongs to the Tom70 family.
CC {ECO:0000256|ARBA:ARBA00038030}.
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DR EMBL; BC123444; AAI23445.1; -; mRNA.
DR EMBL; HM347499; ADK26451.1; -; mRNA.
DR RefSeq; NP_001068796.1; NM_001075328.1.
DR STRING; 9913.ENSBTAP00000019001; -.
DR PaxDb; 9913-ENSBTAP00000019001; -.
DR Ensembl; ENSBTAT00000019001.6; ENSBTAP00000019001.5; ENSBTAG00000014302.6.
DR GeneID; 507707; -.
DR KEGG; bta:507707; -.
DR CTD; 9868; -.
DR VEuPathDB; HostDB:ENSBTAG00000014302; -.
DR VGNC; VGNC:49582; TOMM70.
DR eggNOG; KOG0547; Eukaryota.
DR GeneTree; ENSGT00940000157095; -.
DR HOGENOM; CLU_017516_2_0_1; -.
DR OMA; QWRGDIE; -.
DR OrthoDB; 1083789at2759; -.
DR TreeFam; TF106203; -.
DR Reactome; R-BTA-168928; DDX58/IFIH1-mediated induction of interferon-alpha/beta.
DR Reactome; R-BTA-5205685; PINK1-PRKN Mediated Mitophagy.
DR Reactome; R-BTA-5689880; Ub-specific processing proteases.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000014302; Expressed in oocyte and 105 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0002218; P:activation of innate immune response; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46208; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR PANTHER; PTHR46208:SF1; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 4.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 115..148
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 368..401
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 402..435
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 477..510
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 546..579
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67569 MW; CDA6EB2E5A32511D CRC64;
MAASKPVEAA MVSAAGPGSG SGMGGGSATS GPGTGSLPRW QLALAVGAPL LLGAGALYLW
SRQRRRRETG ARGDSGGLKR NSERKTPEGR ASPAPGSGHP DGPGTHLEMN SLDRAQAAKN
KGNKYFKAGK YEQAIQCYTE AISLCPTEKN VDLSTFYQNR AAAFEQLQKW KEVAQDCTKA
VELNPKYVKA LFRRAKAHEK LDNKKECLED VTAVCILEGF QNQQSMLLAD KVLKLLGKEK
AKEKYKNREP LMPSPQFIKS YFSSFTDDII SQPMLKGEKS DEDKDKEGEA LEVKENSGYL
KAKQYMEEEN YDKIISECSK EIDAQGKYMA EALLLRATFY LLIGNANAAK PDLDKVISLQ
EANVKLRANA LIKRGSMYMQ QQQPLLSTQD FNMAADIDPQ NADVYHHRGQ LKILLDQVEE
AVADFDECIR LRPESALAQA QKCFALYRQA YTGNNSSQIQ AAMKGFEEVI KKFPRCAEGY
ALYAQALTDQ QQFGKADEMY DKCINLEPDN ATTYVHKGLL QLQWKQDLDK GLELISKAIE
IDNKCDFAYE TMGTIEVQRG NMEKAIDMFN KAINLAKSEM EMAHLYSLCD AAHAQTEVAK
KYGLKPPTL
//
