ID Q08FL4_DPV83 Unreviewed; 299 AA.
AC Q08FL4;
DT 31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Leukocyte surface antigen CD47 {ECO:0000256|ARBA:ARBA00015454};
DE AltName: Full=Integrin-associated protein {ECO:0000256|ARBA:ARBA00033289};
DE AltName: Full=Protein OPG166 {ECO:0000256|ARBA:ARBA00034880};
GN ORFNames=DpV83gp139 {ECO:0000313|EMBL:ABI99293.1};
OS Deerpox virus (strain Mule deer/United States/W-848-83/1983) (DPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Cervidpoxvirus;
OC Mule deerpox virus.
OX NCBI_TaxID=305674 {ECO:0000313|EMBL:ABI99293.1, ECO:0000313|Proteomes:UP000000866};
OH NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Cervus hemionus).
RN [1] {ECO:0000313|EMBL:ABI99293.1, ECO:0000313|Proteomes:UP000000866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mule deer/United States/W-848-83/1983
RC {ECO:0000313|Proteomes:UP000000866};
RX PubMed=15613325; DOI=10.1128/JVI.79.2.966-977.2005;
RA Afonso C.L., Delhon G., Tulman E.R., Lu Z., Zsak A., Becerra V.M., Zsak L.,
RA Kutish G.F., Rock D.L.;
RT "Genome of deerpox virus.";
RL J. Virol. 79:966-977(2005).
CC -!- FUNCTION: Promotes, when overexpressed, the influx of extracellular
CC Ca(2+), leading to membrane permeability and host cell necrosis.
CC {ECO:0000256|ARBA:ARBA00034660}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG166 protein family.
CC {ECO:0000256|ARBA:ARBA00034763}.
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DR EMBL; AY689436; ABI99293.1; -; Genomic_DNA.
DR RefSeq; YP_227513.1; NC_006966.1.
DR GeneID; 3346439; -.
DR KEGG; vg:3346439; -.
DR OrthoDB; 19794at10239; -.
DR Proteomes; UP000000866; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070053; F:thrombospondin receptor activity; IEA:InterPro.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:InterPro.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
DR GO; GO:0050766; P:positive regulation of phagocytosis; IEA:InterPro.
DR InterPro; IPR006704; CD47.
DR InterPro; IPR013147; CD47-like_TM.
DR InterPro; IPR013270; CD47_Vset.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR PANTHER; PTHR10613; LEUKOCYTE SURFACE ANTIGEN CD47; 1.
DR PANTHER; PTHR10613:SF0; LEUKOCYTE SURFACE ANTIGEN CD47; 1.
DR Pfam; PF04549; CD47; 1.
DR Pfam; PF08204; V-set_CD47; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283};
KW Reference proteome {ECO:0000313|Proteomes:UP000000866};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 299 AA; 34744 MW; 7928582CAFF603A8 CRC64;
MLNISSLVSI RIYFFILTIF ICFYCSEQTL TTVNSVMYTS CNKTILLTCN LDKLIYDNIS
NIDIRWKVDG NSIFLVNKTY YNLSSLLFNF STSLTGNYTC EAASKFNKIK NIIMLQYTSE
WFTKEEIEIV ISMLSIFIIL LWSELITITF KLNKLKRIIY LYAVSLWITL ILLIGQYMIS
ISSIFTFVKV QGIILIQISI LISMFVQIHL YKYVENSYLI IGNLVLQVIS YLISCIILIL
SFVGCYNQIY IYLFIYKLLF INVLELCNLV LLFITPLGHN IIYKKLHVTT DDIESFSIG
//
