ID   ADH_DROGU               Reviewed;         254 AA.
AC   Q09009;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-APR-2013, entry version 70.
DE   RecName: Full=Alcohol dehydrogenase;
DE            EC=1.1.1.1;
GN   Name=Adh;
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8081544; DOI=10.1006/mpev.1993.1003;
RA   Marfany G., Gonzalez-Duarte R.;
RT   "Characterization and evolution of the Adh genomic region in
RT   Drosophila guanche and Drosophila madeirensis.";
RL   Mol. Phylogenet. Evol. 2:13-22(1993).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; X60113; CAA42711.1; -; Genomic_DNA.
DR   PIR; A40731; A40731.
DR   ProteinModelPortal; Q09009; -.
DR   SMR; Q09009; 2-254.
DR   FlyBase; FBgn0012324; Dgua\Adh.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD) activity; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; -; 1.
DR   InterPro; IPR002425; ADH_Drosophila-type.
DR   InterPro; IPR002424; ADH_insect.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01168; ALCDHDRGNASE.
DR   PRINTS; PR01167; INSADHFAMILY.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    254       Alcohol dehydrogenase.
FT                                /FTId=PRO_0000054463.
FT   NP_BIND      10     33       NAD (By similarity).
FT   ACT_SITE    151    151       Proton acceptor (By similarity).
FT   BINDING     138    138       Substrate (By similarity).
SQ   SEQUENCE   254 AA;  27604 MW;  74C4C3F7F3BCD49A CRC64;
     MSLTNKNVVF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA VNPKVTVTFY
     PYDVTVPVAE TTKLLKTIFA QIKTIDVLIN GAGILDDHQI ERTIAVNYTG LVNTTTAILD
     FWDKRKGGPG GIICNIGSVT GFNAIYQVPV YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN
     PGITKTTLVH KFNSWLDVEP RVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWKLDLGT
     LEPITWTKHW DSGI
//