ID GRK1_CAEEL Reviewed; 642 AA.
AC Q09537;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 01-MAY-2013, entry version 99.
DE RecName: Full=G protein-coupled receptor kinase 1;
DE EC=2.7.11.16;
GN Name=grk-1; ORFNames=F19C6.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Specifically phosphorylates the activated forms of G
CC protein-coupled receptors (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + [G-protein-coupled receptor] = ADP + [G-
CC protein-coupled receptor] phosphate.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. GPRK subfamily.
CC -!- SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
CC -!- SIMILARITY: Contains 1 protein kinase domain.
CC -!- SIMILARITY: Contains 1 RGS domain.
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DR EMBL; Z48006; CAA88047.1; -; Genomic_DNA.
DR PIR; T21112; T21112.
DR RefSeq; NP_509676.1; NM_077275.4.
DR ProteinModelPortal; Q09537; -.
DR SMR; Q09537; 2-593.
DR STRING; 6239.F19C6.1; -.
DR PaxDb; Q09537; -.
DR EnsemblMetazoa; F19C6.1; F19C6.1; F19C6.1.
DR GeneID; 181212; -.
DR KEGG; cel:CELE_F19C6.1; -.
DR UCSC; F19C6.1; c. elegans.
DR CTD; 181212; -.
DR WormBase; F19C6.1; CE01554; WBGene00001708; grk-1.
DR eggNOG; COG0515; -.
DR GeneTree; ENSGT00550000074318; -.
DR HOGENOM; HOG000006742; -.
DR InParanoid; Q09537; -.
DR KO; K08291; -.
DR OMA; EMMETEC; -.
DR NextBio; 912928; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004703; F:G-protein coupled receptor kinase activity; IEA:EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR000239; GPCR_kinase.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_cat_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000342; Regulat_G_prot_signal.
DR InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR00717; GPCRKINASE.
DR SMART; SM00315; RGS; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1 642 G protein-coupled receptor kinase 1.
FT /FTId=PRO_0000086840.
FT DOMAIN 52 188 RGS.
FT DOMAIN 203 470 Protein kinase.
FT DOMAIN 480 545 AGC-kinase C-terminal.
FT NP_BIND 209 217 ATP (By similarity).
FT REGION 1 202 N-terminal.
FT ACT_SITE 328 328 Proton acceptor (By similarity).
FT BINDING 232 232 ATP (By similarity).
SQ SEQUENCE 642 AA; 73778 MW; D2A72CBB364793EA CRC64;
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV TYAFVVEKQP
IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR RDLASSIVSL LHSKPEDNPS
GSQDEQEFWC SFLSDEVIST CITTADSATH DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE
SMYFHRFLQW KWLEKRPVDK HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK
KRHAETLSLN EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF
DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA VEIKDNEPIK
GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA PFRQRKEKVK REEVERRVRE
DQEKYSEKFS EAARTLCRGL LHKEPGFRLG CRRVGRPEDG AEEIRAHPFF NTADTVTGRE
PVPWKKMEAG KVTPPFCPDP RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI
PWQSEMIETE CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV
TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI
//
