ID   Q0A4V3_ALKEH            Unreviewed;       286 AA.
AC   Q0A4V3;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Lipopolysaccharide core heptose(I) kinase {ECO:0000256|PIRNR:PIRNR037318};
DE            EC=2.7.1.- {ECO:0000256|PIRNR:PIRNR037318};
GN   OrderedLocusNames=Mlg_2794 {ECO:0000313|EMBL:ABI58134.1};
OS   Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272 {ECO:0000313|EMBL:ABI58134.1, ECO:0000313|Proteomes:UP000001962};
RN   [1] {ECO:0000313|Proteomes:UP000001962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1
RC   {ECO:0000313|Proteomes:UP000001962};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S.,
RA   Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B.,
RA   Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Kinase involved in the biosynthesis of the core
CC       oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the
CC       phosphorylation of heptose I (HepI), the first heptose added to the
CC       Kdo2-lipid A module. {ECO:0000256|PIRNR:PIRNR037318}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR037318}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/rfaP
CC       family. {ECO:0000256|PIRNR:PIRNR037318}.
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DR   EMBL; CP000453; ABI58134.1; -; Genomic_DNA.
DR   RefSeq; WP_011630527.1; NC_008340.1.
DR   AlphaFoldDB; Q0A4V3; -.
DR   KEGG; aeh:Mlg_2794; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_081267_0_0_6; -.
DR   OrthoDB; 9782725at2; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000001962; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR017172; Lsacc_core_hep_kinase_RfaP.
DR   Pfam; PF06293; Kdo; 1.
DR   PIRSF; PIRSF037318; RfaP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR037318};
KW   Kinase {ECO:0000256|PIRNR:PIRNR037318, ECO:0000313|EMBL:ABI58134.1};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|PIRNR:PIRNR037318};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037318};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001962};
KW   Transferase {ECO:0000256|PIRNR:PIRNR037318}.
SQ   SEQUENCE   286 AA;  33122 MW;  BA56962E914EA400 CRC64;
     MSLRRNELVL DPGFQADLRA TFGPGDPFEQ VMALDGEVVR AVDGRRTFRF ELAGRAYFAK
     LHTGMPWPRI LRKLSQFRVP VLGAEPEWRA IHRLQALGVA TTPPVAFGVR RGLNPARERS
     FVITRDLGHT HTLEQECLRW PEAPPAYTFR VKLIREVARI ARTLHADGMN HRDFYLCHFR
     LDLNDDPPAV LAGRHSPRLY LMDLHRVQRH QSLPERARVK DIGGLYFSAL DIGLTRRDLL
     RFMRAYRGTT LRRTLAADRT FWQQVAERAR WQYRREHGHG PEGLPL
//