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Database: UniProt
Entry: Q0ABW0_ALKEH
LinkDB: Q0ABW0_ALKEH
Original site: Q0ABW0_ALKEH 
ID   Q0ABW0_ALKEH            Unreviewed;       288 AA.
AC   Q0ABW0;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   25-OCT-2017, entry version 77.
DE   SubName: Full=Ion transport protein {ECO:0000313|EMBL:ABI55677.1};
GN   OrderedLocusNames=Mlg_0322 {ECO:0000313|EMBL:ABI55677.1};
OS   Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272 {ECO:0000313|EMBL:ABI55677.1, ECO:0000313|Proteomes:UP000001962};
RN   [1] {ECO:0000313|Proteomes:UP000001962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1
RC   {ECO:0000313|Proteomes:UP000001962};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000213|PDB:4LTO, ECO:0000213|PDB:4LTP, ECO:0000213|PDB:4LTQ}
RP   X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 143-288 IN COMPLEX WITH
RP   CALCIUM.
RX   PubMed=24120938; DOI=10.1016/j.jmb.2013.10.010;
RA   Shaya D., Findeisen F., Abderemane-Ali F., Arrigoni C., Wong S.,
RA   Nurva S.R., Loussouarn G., Minor D.L.;
RT   "Structure of a prokaryotic sodium channel pore reveals essential
RT   gating elements and an outer ion binding site common to eukaryotic
RT   channels.";
RL   J. Mol. Biol. 426:467-483(2014).
RN   [3] {ECO:0000213|PDB:5HJ8, ECO:0000213|PDB:5HK6, ECO:0000213|PDB:5HK7}
RP   X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 143-288.
RX   PubMed=26919429; DOI=10.1016/j.cell.2016.02.001;
RA   Arrigoni C., Rohaim A., Shaya D., Findeisen F., Stein R.A.,
RA   Nurva S.R., Mishra S., Mchaourab H.S., Minor D.L.;
RT   "Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated
RT   Channel Activation.";
RL   Cell 164:922-936(2016).
CC   -!- INTERACTION:
CC       Self; NbExp=3; IntAct=EBI-15936522, EBI-15936522;
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DR   EMBL; CP000453; ABI55677.1; -; Genomic_DNA.
DR   RefSeq; WP_011628073.1; NC_008340.1.
DR   PDB; 4LTO; X-ray; 3.46 A; A/B/C/D=143-288.
DR   PDB; 4LTP; X-ray; 3.80 A; A/B/C/D=143-288.
DR   PDB; 4LTQ; X-ray; 5.50 A; A/B/C/D/H/I/J/K=143-288.
DR   PDB; 4LTR; X-ray; 5.80 A; A/B/C/D=143-288.
DR   PDB; 5HJ8; X-ray; 3.70 A; A/B/C/D=143-288.
DR   PDB; 5HK6; X-ray; 5.50 A; A/B/C/D=143-288.
DR   PDB; 5HK7; X-ray; 2.95 A; A/B/C/D=143-288.
DR   PDB; 5HKD; X-ray; 3.80 A; A/B/C/D=143-288.
DR   PDB; 5IWN; X-ray; 3.75 A; A/B/C/D=143-288.
DR   PDB; 5IWO; X-ray; 3.33 A; A/B/C/D=143-288.
DR   PDBsum; 4LTO; -.
DR   PDBsum; 4LTP; -.
DR   PDBsum; 4LTQ; -.
DR   PDBsum; 4LTR; -.
DR   PDBsum; 5HJ8; -.
DR   PDBsum; 5HK6; -.
DR   PDBsum; 5HK7; -.
DR   PDBsum; 5HKD; -.
DR   PDBsum; 5IWN; -.
DR   PDBsum; 5IWO; -.
DR   ProteinModelPortal; Q0ABW0; -.
DR   SMR; Q0ABW0; -.
DR   DIP; DIP-60398N; -.
DR   STRING; 187272.Mlg_0322; -.
DR   EnsemblBacteria; ABI55677; ABI55677; Mlg_0322.
DR   KEGG; aeh:Mlg_0322; -.
DR   eggNOG; ENOG4105D68; Bacteria.
DR   eggNOG; COG1226; LUCA.
DR   HOGENOM; HOG000004763; -.
DR   KO; K08714; -.
DR   OMA; YWKDGYN; -.
DR   OrthoDB; POG091H17P2; -.
DR   Proteomes; UP000001962; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:4LTO, ECO:0000213|PDB:4LTP,
KW   ECO:0000213|PDB:4LTQ, ECO:0000213|PDB:4LTR};
KW   Calcium {ECO:0000213|PDB:4LTO, ECO:0000213|PDB:4LTP,
KW   ECO:0000213|PDB:5HKD};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001962};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000213|PDB:4LTO, ECO:0000213|PDB:4LTP,
KW   ECO:0000213|PDB:5HKD};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001962};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     34     52       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     64     86       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     98    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    142    167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    214    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35    245       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   METAL       178    178       Calcium 1. {ECO:0000213|PDB:4LTO}.
FT   METAL       209    209       Calcium 2. {ECO:0000213|PDB:4LTO,
FT                                ECO:0000213|PDB:4LTP}.
FT   METAL       209    209       Calcium 3. {ECO:0000213|PDB:4LTO}.
FT   METAL       282    282       Calcium 3. {ECO:0000213|PDB:4LTO}.
FT   METAL       282    282       Calcium 4. {ECO:0000213|PDB:4LTP}.
SQ   SEQUENCE   288 AA;  32978 MW;  A3E7B71D2CA35389 CRC64;
     MSERQPDLVG HKVQHPEDET LRGRLAWFID RPGTQYFIVG LILVNAITLG LMTSPEVTAY
     LQPWLGWVNT FIIAAFVVEI SLRIIADGPR FVRSGWNLFD FSVVAISLVP DSGAFSVLRA
     LRILKVLRLF SMVPRLRRIV EALLRAIPGI AWIALLLLVI FYVFAVMGTK LFAQSFPEWF
     GTLGASMYTL FQVMTLESWS MGIARPVIEA YPWAWIYFVS FILVSSFTVL NLFIGIIIES
     MQSAHWEAED AKRIEQEQRA HDERLEMLQL IRDLSSKVDR LERRSGKR
//
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