ID UBIA_NITEC Reviewed; 286 AA.
AC Q0AGZ9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 01-MAY-2013, entry version 54.
DE RecName: Full=4-hydroxybenzoate octaprenyltransferase;
DE EC=2.5.1.-;
DE AltName: Full=4-HB polyprenyltransferase;
GN Name=ubiA; OrderedLocusNames=Neut_1128;
OS Nitrosomonas eutropha (strain C91).
OC Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=335283;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C91;
RX PubMed=17991028; DOI=10.1111/j.1462-2920.2007.01409.x;
RA Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S.,
RA Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M.,
RA Wei X.;
RT "Whole-genome analysis of the ammonia-oxidizing bacterium,
RT Nitrosomonas eutropha C91: implications for niche adaptation.";
RL Environ. Microbiol. 9:2993-3007(2007).
CC -!- FUNCTION: Synthesis of 3-octaprenyl-4-hydroxybenzoate (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC 3-octaprenyl-4-hydroxybenzoate.
CC -!- COFACTOR: Magnesium (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
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DR EMBL; CP000450; ABI59383.1; -; Genomic_DNA.
DR RefSeq; YP_747348.1; NC_008344.1.
DR STRING; 335283.Neut_1128; -.
DR EnsemblBacteria; ABI59383; ABI59383; Neut_1128.
DR GeneID; 4272410; -.
DR KEGG; net:Neut_1128; -.
DR PATRIC; 22719517; VBINitEut7577_1423.
DR eggNOG; COG0382; -.
DR HOGENOM; HOG000003696; -.
DR KO; K03179; -.
DR OMA; YHYTLIR; -.
DR ProtClustDB; PRK12848; -.
DR BioCyc; NEUT335283:GHT6-1174-MONOMER; -.
DR UniPathway; UPA00232; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IEA:HAMAP.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_01635; UbiA; 1; -.
DR InterPro; IPR006370; HB_polyprenyl-transferase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR PROSITE; PS00943; UBIA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Magnesium;
KW Membrane; Transferase; Transmembrane; Transmembrane helix;
KW Ubiquinone biosynthesis.
FT CHAIN 1 286 4-hydroxybenzoate octaprenyltransferase.
FT /FTId=PRO_1000069826.
FT TRANSMEM 20 40 Helical; (Potential).
FT TRANSMEM 43 63 Helical; (Potential).
FT TRANSMEM 83 103 Helical; (Potential).
FT TRANSMEM 105 125 Helical; (Potential).
FT TRANSMEM 135 155 Helical; (Potential).
FT TRANSMEM 160 180 Helical; (Potential).
FT TRANSMEM 209 229 Helical; (Potential).
FT TRANSMEM 234 254 Helical; (Potential).
SQ SEQUENCE 286 AA; 31507 MW; 774F1CB988AAB4D7 CRC64;
MTFSERFSAY ARLTRLDKPI GILLLLWPTL WGLWLAADGM PDPMILVIFV LGTILMRSAG
CAINDFADRK IDPHVSRTRN RPLATGIISS REALLVAAGL SLCAFLLILP LNLLTILLSV
PALLLAISYP FTKRFFAMPQ AYLGIAFSFG IPMAFAAQTG TVPPLAWLLV LANLFWVIAY
DTEYALVDLA DDLKIGIKTS AITFGRFDVA GILLCHITFL SILTYAGILL QRGIWFYGAL
LVALGLVIVQ YTMIRNREPA RCFQAFLHNN RVGAVIFAGI LLDTLI
//
