ID   Q0BFB5_BURCM            Unreviewed;       320 AA.
AC   Q0BFB5;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:ABI87158.1};
DE            EC=4.1.3.4 {ECO:0000313|EMBL:ABI87158.1};
GN   OrderedLocusNames=Bamb_1600 {ECO:0000313|EMBL:ABI87158.1};
OS   Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia
OS   (strain AMMD)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=339670 {ECO:0000313|EMBL:ABI87158.1, ECO:0000313|Proteomes:UP000000662};
RN   [1] {ECO:0000313|Proteomes:UP000000662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-244 / AMMD {ECO:0000313|Proteomes:UP000000662};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K.,
RA   Ramette A., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC       {ECO:0000256|ARBA:ARBA00009405}.
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DR   EMBL; CP000440; ABI87158.1; -; Genomic_DNA.
DR   RefSeq; WP_011656886.1; NZ_CP009798.1.
DR   AlphaFoldDB; Q0BFB5; -.
DR   GeneID; 69544233; -.
DR   KEGG; bam:Bamb_1600; -.
DR   PATRIC; fig|339670.21.peg.3366; -.
DR   eggNOG; COG0119; Bacteria.
DR   Proteomes; UP000000662; Chromosome 1.
DR   GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07938; DRE_TIM_HMGL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR043594; HMGL.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:ABI87158.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
SQ   SEQUENCE   320 AA;  34084 MW;  BC6F2F90CC329FA2 CRC64;
     MSQHPQRLYI HEVATRDGFQ NEAAFVDTDD KIALVDALSA CGYAKIEVTS FTSPKAIPAL
     RDAEAVMHGI VRAPGVVYTV LVPNVRGAQR ALSCGVDEVN LVMSMSESHN RANLRMSREQ
     SFAQLRDVID AVRGTGVAIN VSLSTAMGCP MEGDVRDETV LAWMQRFADL GVHGFTLCDT
     TGMAYPSQVR ALAERARERF GALQLTLHFH NTRGMALANT LAALDAGIER FDASLGGLGG
     CPYAPGATGN ACTEELVHML ALDGYDTGID LAAVLAAAAR LPALIGHDVP SQILKAGRRS
     DLHPAPRAEA GDMPAQRAFS
//