ID Q0C9F7_ASPTN Unreviewed; 609 AA.
AC Q0C9F7;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=Polyadenylation factor subunit 2 {ECO:0000256|ARBA:ARBA00026154, ECO:0000256|RuleBase:RU369034};
GN ORFNames=ATEG_09677 {ECO:0000313|EMBL:EAU29868.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU29868.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC mRNAs. Also involved in chromosome segregation where it has a role in
CC chromosome attachment to the mitotic spindle.
CC {ECO:0000256|ARBA:ARBA00025498}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369034}.
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DR EMBL; CH476608; EAU29868.1; -; Genomic_DNA.
DR RefSeq; XP_001218299.1; XM_001218298.1.
DR AlphaFoldDB; Q0C9F7; -.
DR STRING; 341663.Q0C9F7; -.
DR EnsemblFungi; EAU29868; EAU29868; ATEG_09677.
DR GeneID; 4354358; -.
DR VEuPathDB; FungiDB:ATEG_09677; -.
DR eggNOG; KOG0284; Eukaryota.
DR HOGENOM; CLU_000288_77_1_1; -.
DR OMA; YGSSMVQ; -.
DR OrthoDB; 5487329at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR GO; GO:0180010; P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway; IEA:EnsemblFungi.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045245; Pfs2-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22836:SF0; PRE-MRNA 3' END PROCESSING PROTEIN WDR33; 1.
DR PANTHER; PTHR22836; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|RuleBase:RU369034};
KW Nucleus {ECO:0000256|RuleBase:RU369034};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 94..126
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 182..223
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 224..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 266..301
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 309..341
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 379..411
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..512
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67289 MW; 0149AE08A0F5C7EF CRC64;
MAYYDESGGD SQPYGRPPKS YEGGILGPRR PRLVTDYGSS LVQWMRTRRP RYKGGHRMET
ERPSASYVVD MLPPLARVHS PADTIPVRHL HQSIGKSKKP ITVVRWTPEG RRLLTGGHTG
EFMLWNGTAF NFETVMDAHY DQLQAGVTSI SWSHSHDWLI SGGQKGDIKY WRPNFNNVET
IDDAHHDAVR DLAWSPSDTK FLSASDDTTL KIFDFTSRTA DTILTGHNWD VKSCDWHPTK
GLLVSGSKDH QVKFWDPRTT RCLTTLHSHK NTVTTTRFSR VNSNLLATSS RDQTARVFDL
RMMRDICILR GHEKPVSSLT WHPIHSTLIS TGSEDGSLYH YLLDEPNVPS GQVPTIAPYN
STDPTTTPAQ VIYPAHRIQY AHSATIWSLD WHPLGHILAS GSKDNFTRFW SRARPGETSY
MKDRFHIGEE AAEAQGTWNR GFGKRQMREE EEQELQDEAE SLVDQKKSAG SFLPGIQIAP
PGSGPQQDGM GSQLLPGIGA PQPPPQAGMP ASMPPMDPSR LAALLSSQPP PQANNFPPNT
GLPGFPLLPA LSGTPPANLD LAELQKQLLS QGISLPQGFP QNFPAMPQMG AGGLPGLQGG
GTPNNRFGR
//
