ID   Q0CDX3_ASPTN            Unreviewed;       605 AA.
AC   Q0CDX3;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=alpha-L-fucosidase {ECO:0000256|ARBA:ARBA00012662};
DE            EC=3.2.1.51 {ECO:0000256|ARBA:ARBA00012662};
GN   ORFNames=ATEG_08111 {ECO:0000313|EMBL:EAU31284.1};
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU31284.1, ECO:0000313|Proteomes:UP000007963};
RN   [1] {ECO:0000313|Proteomes:UP000007963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC       1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC       carbohydrate moieties of glycoproteins.
CC       {ECO:0000256|ARBA:ARBA00004071}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 29 family.
CC       {ECO:0000256|ARBA:ARBA00007951}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476605; EAU31284.1; -; Genomic_DNA.
DR   RefSeq; XP_001216732.1; XM_001216732.1.
DR   AlphaFoldDB; Q0CDX3; -.
DR   STRING; 341663.Q0CDX3; -.
DR   EnsemblFungi; EAU31284; EAU31284; ATEG_08111.
DR   GeneID; 4353505; -.
DR   VEuPathDB; FungiDB:ATEG_08111; -.
DR   eggNOG; KOG3340; Eukaryota.
DR   HOGENOM; CLU_002934_6_0_1; -.
DR   OMA; WESTDKH; -.
DR   OrthoDB; 2955544at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0004560; F:alpha-L-fucosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.20.10; Crystallins; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR016286; FUC_metazoa-typ.
DR   InterPro; IPR031919; Fucosidase_C.
DR   InterPro; IPR000933; Glyco_hydro_29.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR   PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR   Pfam; PF01120; Alpha_L_fucos; 1.
DR   Pfam; PF16757; Fucosidase_C; 1.
DR   PRINTS; PR00741; GLHYDRLASE29.
DR   SMART; SM00812; Alpha_L_fucos; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..605
FT                   /note="alpha-L-fucosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004170202"
FT   DOMAIN          423..509
FT                   /note="Alpha-L-fucosidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16757"
SQ   SEQUENCE   605 AA;  66504 MW;  42AB015FAA7AA065 CRC64;
     MKIPLPIAIA ISVVVPARGL PQAQEVYEPT WESTDKHTAA PGWFRDAKFG VYWHWGAFST
     PQFGSEWYGR NMYLPDTKER VEHTRRYGPP EEWGYENFIV GAPDLQGNHV QFKPVLASEG
     GSFDPAAWMR VVKASGAQFA GPVAEHHDGF SMWESEVNEW NSVDRGPELD LLKIFAGLVR
     ENGMKLLVAM HHAFNTNGFF SAAPRQTDPS LQKLFGQLPK NVSDQLWFDK QREVIDHVQP
     DIIWNDFSLN SPGWCQGASD YCSIAENQRL KYLAYYFNRG VEWNKEVLTT HKHFDPGFHD
     TSAVSDFERG GPAEITRPYW LTDDAISASS WSYTEGIAYY NSTQMIHSLI DRVSKNGNML
     LNISPTAAGV LPVEQERVLR DIGTYLGRYG ESVYGTRAWD IYGEGPNKAG GGSFTAPLLG
     NSSDVRFTRN KDGNVLYVTV LGWPSGRNVS VNSLGGSSLV SLSGLVSIQL LGDQAGEFID
     VAGWTQTTDA LVISLPQQPA ASPAYVLKMS FKQYIPVPQL PFGASIFPAE HPTGKGVALA
     EGQFSSVFLT EAGLNPADIR FLRVSPSTVV TGYIGTNLTG TSTSYDAGEH RIVPGSLGSL
     AVARQ
//