ID Q0CHW2_ASPTN Unreviewed; 642 AA.
AC Q0CHW2;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Cytochrome P450 {ECO:0008006|Google:ProtNLM};
GN ORFNames=ATEG_06722 {ECO:0000313|EMBL:EAU33266.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU33266.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602403-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR EMBL; CH476602; EAU33266.1; -; Genomic_DNA.
DR RefSeq; XP_001215900.1; XM_001215900.1.
DR AlphaFoldDB; Q0CHW2; -.
DR STRING; 341663.Q0CHW2; -.
DR EnsemblFungi; EAU33266; EAU33266; ATEG_06722.
DR GeneID; 4322311; -.
DR VEuPathDB; FungiDB:ATEG_06722; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_426393_0_0_1; -.
DR OMA; HVQHTIY; -.
DR OrthoDB; 1611592at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd00302; cytochrome_P450; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24305; CYTOCHROME P450; 1.
DR PANTHER; PTHR24305:SF87; CYTOCHROME P450 MONOOXYGENASE ALND-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00465; EP450IV.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|PIRSR:PIRSR602403-1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR602403-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602403-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963}.
FT BINDING 379
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602403-1"
SQ SEQUENCE 642 AA; 71098 MW; 64542C800DDC0272 CRC64;
MGKTIYLTDD PAVAAVCLAE SAYMTKKINS DHPLWGVKDN TAIFLGDTET ENWRLAHKYL
PPSMGPKAVR HYTGLMQACA RKSLPVFDEL DARDEAWNVY QYMLKLASQT VGSFSLSKDF
GHFDSIDSPL HPIVTNIASL LSLNKKITAR GEWYRHLPFG DPARLRHVQH TIYSLLQEQI
DAVAAESRSA DAPMADAALS ATCAVDYLLH AVDDKGERFP PGLILANVLV VTGAGFTTTS
ALLSWLIYCL VTYEGTQDRL YQELVEYGIV GPNGERNQTT WTPDLAHSLP YMDKFVKETQ
RLHNASFQPG RTSKTDVVLP GGYRLPPDSV IVPALYAIHT NPKIWRDPFR FDPDRWDTDE
VKNRHRCAYV PFATGPRGCI GFNFALLEVK ILLGELLSRY EFVREGQEAI DYDPEFQLIR
PLNFYRPGIR PEVAHVGVSI APLGVFLLLL EYSGQPLHEE VWLLPVIDRH VAETLERDGA
AHGVVHKRPH AAHAGREAVQ IEEALDGLHR ALHAVYRCSR GRLIGCVCVH AIQVYTVEPT
GHIAEVDAQS QPLQMVLHRD AAALVGKEGR GGVADAVQLA LGLAHALERI LHVTGCFLTG
FILDQMADGE DAFFVREAVG VAVVRDRTGH GDGAERAVVY EG
//
