ID Q0CIT8_ASPTN Unreviewed; 449 AA.
AC Q0CIT8;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=phosphoethanolamine N-methyltransferase {ECO:0000256|ARBA:ARBA00035674};
DE EC=2.1.1.103 {ECO:0000256|ARBA:ARBA00035674};
GN ORFNames=ATEG_06396 {ECO:0000313|EMBL:EAU32940.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU32940.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-
CC methylethanolamine phosphate + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:20365, ChEBI:CHEBI:15378, ChEBI:CHEBI:57781,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:58190, ChEBI:CHEBI:59789;
CC EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00035571};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20366;
CC Evidence={ECO:0000256|ARBA:ARBA00035571};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004969}.
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DR EMBL; CH476602; EAU32940.1; -; Genomic_DNA.
DR RefSeq; XP_001215574.1; XM_001215574.1.
DR AlphaFoldDB; Q0CIT8; -.
DR STRING; 341663.Q0CIT8; -.
DR EnsemblFungi; EAU32940; EAU32940; ATEG_06396.
DR GeneID; 4322178; -.
DR VEuPathDB; FungiDB:ATEG_06396; -.
DR eggNOG; ENOG502SHJW; Eukaryota.
DR HOGENOM; CLU_049332_1_0_1; -.
DR OMA; NEPAWRR; -.
DR OrthoDB; 710013at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR44307:SF20; METHYLTRANSF_25 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44307; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 43..132
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT DOMAIN 272..317
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
SQ SEQUENCE 449 AA; 50316 MW; 0CC9A08CC9755398 CRC64;
MTVSAEELFN GLGQQYEESY VDNAGLEEVI DCALKELPPK SRVLDVGCGT GKPVAARVAR
AGHEIHGIDI SQEMVNIASR QVIGRFEKAD MTTFQPSKQY DAIFTIFSMF QLSHSQTYSM
MYKYSEWLKT GGLLVLGTIP STSLVDDEGL YDASGKVVRH ADLLFMGRRF LGTVYTKDGW
RELFRAAGFI IQLERSFTFN AKPPYDKEIQ DHYLIIAKKV VDHALLGPYP FPTSYRGPHP
LSEAAWAPFA ERLVRDEFDA VLEVIKGSKK VLDVGSGYGK EIPFRDRTFD AAVAMWILHY
VDDLDKSLRE IARVVDPSRP GSRIVIVQGA PDNEVVNLLN DICAPLSAQN TAIDHQGYLL
NAAATVFAEY GFNDVKVFRV NAYCAFPEED LTERCQKAAE VLAGFWFRDD PNFVQMKEAL
IPHLKLHFRD RPHAINDEVA VLVAKPLPN
//