ID Q0CKP4_ASPTN Unreviewed; 540 AA.
AC Q0CKP4;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ATEG_05740 {ECO:0000313|EMBL:EAU33501.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU33501.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; CH476601; EAU33501.1; -; Genomic_DNA.
DR RefSeq; XP_001214918.1; XM_001214918.1.
DR AlphaFoldDB; Q0CKP4; -.
DR STRING; 341663.Q0CKP4; -.
DR EnsemblFungi; EAU33501; EAU33501; ATEG_05740.
DR GeneID; 4321315; -.
DR VEuPathDB; FungiDB:ATEG_05740; -.
DR eggNOG; KOG3043; Eukaryota.
DR HOGENOM; CLU_504293_0_0_1; -.
DR OMA; FANELVW; -.
DR OrthoDB; 5478361at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR002925; Dienelactn_hydro.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00745; apbA_panE; 1.
DR PANTHER; PTHR21708:SF30; 2-REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00740)-RELATED; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR Pfam; PF01738; DLH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007963}.
FT DOMAIN 19..180
FT /note="Dienelactone hydrolase"
FT /evidence="ECO:0000259|Pfam:PF01738"
FT DOMAIN 209..356
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 397..525
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 540 AA; 58709 MW; 222641AC8C3EDBC4 CRC64;
MAIQTLQGAD ILATRLNAVV LVPDFFHGAA AQHDWIPPDS EEKQRLITDL IENQASIPKN
VEVLREAVAA YRTVFPSVQK WAALGLCWGG KVAVLASGAE TPFAVTGQVH PGRMEQADAE
NLTIPHIVLA SKDEPADIVN HYTDILARNG IGGHVETYTT MWHGWMGARA RLDEKESSAE
YIRGYTQIAD FFENNNPRNT STNMAPSVLL FGVGSVGGVY LYQLQQAGCT VTAVCRSNYD
AVQQHGFTLQ SKQFGTVTYR PDHLVRTLSD CPPDAVYDYL IVTTKSFPAS SNSRSPLAEQ
LQPALANRPN TTIVLAQNGI EIEPEIAAAF PANPLLSAVI YLPATQIAPG VIEYPETLNV
LELGTYPADA PAAHKASAQV LAERMRAGGS DVSVLEDVQT ARWAKLIVNA SWNPVCALAL
CTDGDFLRCA DPFARDLVWG IMMEIVALAK AAGVPGVDEE AAAKRMAVAT RRAETRTGRE
PSMLQDVRQG RPFEVGAIMG NAVRLERKWG VAMPRLETVY PLAKGRYEAM VRELRMSSRA
//