ID EIF3B_ASPTN Reviewed; 742 AA.
AC Q0CN46;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=prt1; ORFNames=ATEG_04888;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CH476599; EAU35335.1; -; Genomic_DNA.
DR RefSeq; XP_001214066.1; XM_001214066.1.
DR AlphaFoldDB; Q0CN46; -.
DR SMR; Q0CN46; -.
DR STRING; 341663.Q0CN46; -.
DR EnsemblFungi; EAU35335; EAU35335; ATEG_04888.
DR GeneID; 4320016; -.
DR VEuPathDB; FungiDB:ATEG_04888; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR OMA; LWGGPQF; -.
DR OrthoDB; 5479191at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED; 1.
DR PANTHER; PTHR14068:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..742
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363812"
FT DOMAIN 40..126
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 193..230
FT /note="WD 1"
FT REPEAT 232..290
FT /note="WD 2"
FT REPEAT 304..345
FT /note="WD 3"
FT REPEAT 515..558
FT /note="WD 4"
FT REPEAT 573..611
FT /note="WD 5"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 84189 MW; 2341EC202449E3AE CRC64;
MAPSFDTLSE QDLHEEEEEE IDFSDLKAQY EVKLDEGLDT FVVIDGLPIV PEESRQKLIK
FLLRKLSAAG KTSEDAVFMP LNEKNMSEGF AFVEYETPEQ AVAAVKQLHG TPLDKKHTLA
VNKLMDIDRY GREGRIDEEY KPPTIEPFKE KEHLRSWLAD PNARDQFALY RGDKVGVFWN
NKNNPPENVV DRAHWTQLFV QWSPKGTYLA SVHPQGIQLW GGPAFSKLKQ FPHPFVSLVE
FSPAENYVTT WSARPIQVEE GGSGPLSYEE DGKNIIIWDI VTGKPLRSFV SHDLAAGPAE
AEAQPKKKVQ WPAFKWSADE KYVARMLQGQ SISIYEAPRM NLLGKTSVKI DGVMDFEWSP
ATVNRDGVKQ YEQLLCFWTP EIGSNPARVG MMSVPSKEIV RTRNLFNVSD VKLHWQSQGT
YVCVKVDRHS KSKKSMATNL EIFRVREKGV PVEVVDSLKD TVINFAWEPN GGRFVLITTG
ETPTGAAVPP KTAVSFFAPE KKGGSAGNFK LVRTIEKKTS NAIYWSPKGR FVVVATVHSQ
SSFDLDFWDM DFEGEKPEGE KDLAANLQLM KTVEHYGVTD VDWDPTGRYV VSSASVWTHS
MENGWNLHTF AGQTLSENPT DKFKQFIWRP RPPTLLSKEE QKQVRKNLRE YSKEFDEEDK
YAVDIANTAV VEKRKRVLSE WLAWIRREKE LLAEDKDAYG LPENVDDAKM AKDAPQVSED
QGETVVEEIV EEIIEENEEV IG
//
