ID Q0CNL3_ASPTN Unreviewed; 994 AA.
AC Q0CNL3;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=ATEG_04721 {ECO:0000313|EMBL:EAU35168.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU35168.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000256|ARBA:ARBA00007520}.
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DR EMBL; CH476599; EAU35168.1; -; Genomic_DNA.
DR RefSeq; XP_001213899.1; XM_001213899.1.
DR AlphaFoldDB; Q0CNL3; -.
DR EnsemblFungi; EAU35168; EAU35168; ATEG_04721.
DR GeneID; 4320188; -.
DR VEuPathDB; FungiDB:ATEG_04721; -.
DR eggNOG; KOG0156; Eukaryota.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_300892_0_0_1; -.
DR OrthoDB; 1202047at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11060; CYP57A1-like; 1.
DR CDD; cd17502; MFS_Azr1_MDR_like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23501:SF102; DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED; 1.
DR PANTHER; PTHR23501; MAJOR FACILITATOR SUPERFAMILY; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR01036; TCRTETB.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 457..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 465..959
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 425..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 107880 MW; CB8347A38213390F CRC64;
MSLSGPLVRI GPKWVLCGDP AEIRRIWGIK SGYYRSDWYK AVRLNSEVDN VLSVIDNKDH
HRLRSHLMPG YGGKGIANEE QLVDQQITKL IALIEKRYIS SKEALRPCDL ARTMQYLTQD
VITAVGFGKP AGYLEANSDM YGILETSEAL HRPVHMVTLL PTLRKILESR PLKPLQPKPH
DGSGVGRFLG YIKDLVDERY DDLKANHTDI LQSFIKSGLN RPQVESEALV TVFGGTDTTS
TALRNIIFYL STTPRAYRAL QSEIDGAVKT VTRPVIRDAE AKALPYLQAC IKEGLRIFPP
SMGLMGKVCP RDDTICGIKV PANTQVAWSA LAIMRNRAIF GEDADIYEPQ RWIDAPVERR
KEMDASYGLV FATGTRWECL GKRLAYIELG KTIFELFRRF DFAMVNPVEP FRYFVLTMSK
TLEPAGVSSA SDSPSDTPGS TVDNDTPASS SAESPRLTTA TIALTMMSLC LSVLLSALDL
TIVTPAIPAI VGTFKSAAAY IWVGSAYTLA YAAITPVWGS VSDIWGRKPI MLIAVAVFLV
GSLVCALAPH MDALVAGRAI QGLGGSGMGI MVNIVVSDMF SLRDRGLYLA ITSLVWAVGS
AIGPVLGGVF TTRLTWRWCF WINLPVGAVS FLVLLFFMRV PSPRTPIAAG LKVIDWTGSL
LIVGGSLMVL LALDFGDVVY SWSSATVICL LVFGTAVMAL FVLNEWKIAK NPIIPVWLFT
SPTKIAPYVV FACNSYVFIG QAYYLPLYAQ SVLAASALTS GLYLLPLIVS CSLAAAAAGI
FMQQTGKYLP VMYIAQGFLV LGSGLLINLE FETSIAKLII FQILIGIGVG MNIEAPILAA
QAATSVRDTA AVTATMGFVR SLSTAISVVV GGVVFQNEMN AKNEGLATQL GSNSTLAREF
NGDLAAASVE EIGTLGLDAD QEALVRKTYF EALRMVWVMY VAFAGLATVL NLFVRAHKLR
DENEGAVLGA DRARPQGNPA DGAAELEMRN ERSD
//