ID Q0E866_ECOLX Unreviewed; 479 AA.
AC Q0E866;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Membrane fusion protein (MFP) family protein {ECO:0000256|RuleBase:RU365093};
GN Name=hlyD {ECO:0000313|EMBL:ACL51963.1};
GN Synonyms=ehxD {ECO:0000313|EMBL:EFI0215878.1};
GN ORFNames=BG944_005187 {ECO:0000313|EMBL:EFI0215878.1}, C9E67_30050
GN {ECO:0000313|EMBL:QCL51276.1}, DIV22_17545
GN {ECO:0000313|EMBL:PZZ65490.1}, EAX79_28365
GN {ECO:0000313|EMBL:EAB0921520.1};
OS Escherichia coli.
OG Plasmid pO145-NM {ECO:0000313|EMBL:ADZ45126.1},
OG Plasmid pO26-Vir {ECO:0000313|EMBL:ACL51963.1},
OG Plasmid pSFO157 {ECO:0000313|EMBL:AAR00411.1},
OG Plasmid pTA143 {ECO:0000313|EMBL:QCL51276.1},
OG Plasmid pta143 {ECO:0000313|Proteomes:UP000298553}, and
OG Plasmid unnamed {ECO:0000313|EMBL:ACR56509.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAR00411.1};
RN [1] {ECO:0000313|EMBL:AAR00411.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3072/96 {ECO:0000313|EMBL:AAR00411.1};
RC PLASMID=pSFO157 {ECO:0000313|EMBL:AAR00411.1};
RX PubMed=11401985; DOI=10.1128/IAI.69.7.4447-4457.2001;
RA Brunder W., Khan A.S., Hacker J., Karch H.;
RT "Novel type of fimbriae encoded by the large plasmid of sorbitol-fermenting
RT enterohemorrhagic Escherichia coli O157:H(-).";
RL Infect. Immun. 69:4447-4457(2001).
RN [2] {ECO:0000313|EMBL:AAR00411.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3072/96 {ECO:0000313|EMBL:AAR00411.1};
RC PLASMID=pSFO157 {ECO:0000313|EMBL:AAR00411.1};
RX PubMed=16887390; DOI=10.1016/j.ijmm.2006.05.005;
RA Brunder W., Karch H., Schmidt H.;
RT "Complete sequence of the large virulence plasmid pSFO157 of the sorbitol-
RT fermenting enterohemorrhagic Escherichia coli O157:H- strain 3072/96.";
RL Int. J. Med. Microbiol. 296:467-474(2006).
RN [3] {ECO:0000313|EMBL:ACL51963.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H30 {ECO:0000313|EMBL:ACL51963.1};
RC PLASMID=pO26-Vir {ECO:0000313|EMBL:ACL51963.1};
RA Fratamico P.M., Yan X., Morabito S., Esposito G., Needleman D.S., Pepe T.,
RA Tozzoli R., Cortesi M.L., Caprioli A.;
RT "The DNA sequence of the virulence plasmid and 5 additional plasmids
RT carried by Shiga toxin-producing Escherichia coli O26:H11 strain H30.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ACR56509.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=83-75 {ECO:0000313|EMBL:ACR56509.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:ACR56509.1};
RA Yan X., Needleman D.S., Fratamico P.M.;
RT "Annotation of Escherichia coli O145:NM strain 83-75 virulence plasmid.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:ADZ45126.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=83-75 {ECO:0000313|EMBL:ADZ45126.1};
RC PLASMID=pO145-NM {ECO:0000313|EMBL:ADZ45126.1};
RX PubMed=22370037; DOI=10.1016/j.plasmid.2012.02.001;
RA Yan X., Fratamico P.M., Needleman D.S., Bayles D.O.;
RT "DNA sequence and analysis of a 90.1-kb plasmid in Shiga toxin-producing
RT Escherichia coli (STEC) O145:NM 83-75.";
RL Plasmid 68:25-32(2012).
RN [6] {ECO:0000313|EMBL:QCL51276.1, ECO:0000313|Proteomes:UP000298553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=143 {ECO:0000313|EMBL:QCL51276.1,
RC ECO:0000313|Proteomes:UP000298553};
RC PLASMID=pTA143 {ECO:0000313|EMBL:QCL51276.1}, and pta143
RC {ECO:0000313|Proteomes:UP000298553};
RA Bono J.L., Arthur T.M.;
RT "WGA of Escherichia coli O157:H7: comparison of multiple isolates.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:PZZ65490.1, ECO:0000313|Proteomes:UP000248865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14-391 {ECO:0000313|EMBL:PZZ65490.1,
RC ECO:0000313|Proteomes:UP000248865};
RA Karnisova L., Nunvar J., Marejkova M., Mellmann A., Drevinek P.,
RA Blahova K., Bielaszewska M.;
RT "Genomic sequencing of EHEC O26 New European Clone.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:EAB0921520.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2014C-3796 {ECO:0000313|EMBL:EFI0215878.1,
RC ECO:0000313|Proteomes:UP000521994}, and PNUSAE019345
RC {ECO:0000313|EMBL:EAB0921520.1};
RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU365093}; Single-pass membrane protein
CC {ECO:0000256|RuleBase:RU365093}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|RuleBase:RU365093}.
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DR EMBL; AF401292; AAR00411.1; -; Genomic_DNA.
DR EMBL; FJ386569; ACL51963.1; -; Genomic_DNA.
DR EMBL; FJ875096; ACR56509.1; -; Genomic_DNA.
DR EMBL; HM138194; ADZ45126.1; -; Genomic_DNA.
DR EMBL; AAADNP010000092; EAB0921520.1; -; Genomic_DNA.
DR EMBL; AASXRC010000059; EFI0215878.1; -; Genomic_DNA.
DR EMBL; QFSS01000141; PZZ65490.1; -; Genomic_DNA.
DR EMBL; CP028608; QCL51276.1; -; Genomic_DNA.
DR RefSeq; WP_001213545.1; NZ_WXYV01000003.1.
DR RefSeq; YP_001294702.1; NC_009602.1.
DR RefSeq; YP_002756568.1; NC_012487.1.
DR PATRIC; fig|562.11480.peg.5304; -.
DR OMA; IKIEAFP; -.
DR Proteomes; UP000248865; Unassembled WGS sequence.
DR Proteomes; UP000298553; Plasmid pta143.
DR Proteomes; UP000521994; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR006144; Secretion_HlyD_CS.
DR InterPro; IPR010129; T1SS_HlyD.
DR NCBIfam; TIGR01843; type_I_hlyD; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF26; TRANSPORT PROTEIN COMB; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR PRINTS; PR01490; RTXTOXIND.
DR PROSITE; PS00543; HLYD_FAMILY; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU365093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365093}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365093};
KW Plasmid {ECO:0000313|EMBL:AAR00411.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365093};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365093}.
FT TRANSMEM 59..77
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365093"
FT COILED 262..296
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 479 AA; 54524 MW; F664B17101D95693 CRC64;
MRFYMKGLWD LVCRYKTVFS DVWKIRHTLD APVREKDEYA FLPAHLELIE TPVSRRSHFV
VWSILLFVII SLLLSVLGKV EVVSVANGKF THSGRSKEIK PIENAIVEKI MVKDGSFVKK
NDPLVELTVP GVESDILKSE ASLLYEKTEQ YRYAILSESI QRNELPEIRI TDFPGGEDNA
GGEHFQRVSS LIKEQFMTWQ NRKNQKQLTL NKKIVERDAA LARVSLYEHQ VSQEGRKLND
FKYLLNKKAV SQHSVMEQEN SYIQAKNEHA VWLAQVSQLE KEIELVREEL ALETNIFRSE
IIEKHRKSTD NIVLLEHELE KNRQRKASSF IKAPVSGTVQ ELNIHTEGGV VTTAETLMII
VPDNDILEVT ASVLNKDIGF IQPGQEVVIK VDAYPYTRHG YLTGKVKNIT ADSVSVPDTG
LVFNVIISVD RNDIQGERKK IPVTAGMTVM AEIKTGVRSV ISYLLSPLKE TINESLRER
//
