ID Q0GKD3_MUSSP Unreviewed; 1186 AA.
AC Q0GKD3;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=NACHT-, LRR-, and PYD-containing protein 1 paralog b {ECO:0000313|EMBL:ABI18118.1};
GN Name=Nalp1b {ECO:0000313|EMBL:ABI18118.1};
OS Mus spretus (Western Mediterranean mouse) (Algerian mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10096 {ECO:0000313|EMBL:ABI18118.1};
RN [1] {ECO:0000313|EMBL:ABI18118.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPRET/EiJ {ECO:0000313|EMBL:ABI18118.1};
RA Boyden E.D., Dietrich W.F.;
RT "Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Constitutes the precursor of the Nlrp1a inflammasome, which
CC mediates autoproteolytic processing within the FIIND domain to generate
CC the N-terminal and C-terminal parts, which are associated non-
CC covalently in absence of pathogens and other damage-associated signals.
CC {ECO:0000256|ARBA:ARBA00029394}.
CC -!- SUBUNIT: Interacts with the C-terminal part of Nlrp1a (NACHT, LRR and
CC PYD domains-containing protein 1a, C-terminus) in absence of pathogens
CC and other damage-associated signals. {ECO:0000256|ARBA:ARBA00024369}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; DQ860105; ABI18118.1; -; mRNA.
DR AlphaFoldDB; Q0GKD3; -.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 130..439
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 793..1076
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1086..1169
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 135589 MW; 3448EC982093562C CRC64;
MEESQSKQES STKVAQHEGQ EDVDPTFKTK KLMEVELMKH RVQLERDLKL GTIPKVDIKQ
EGETLDPTWS RKRENLVQKL TNLLLFEKLC SRGSENLTRK SWYSCEEERG HMIEIQDLFG
PNIGTQKEPQ LVIIEGAAGI GKSTLARQVK RAWKEGQLYR DHFQHVFFLT CRELAQYEQL
SLAELIAQGQ EVPTVPIRQI LSHPEKLLFI LDGIDEPAWV LADQNPELCL HWSQRQPVHT
LLGSLLGKSI LPEASFLLTA RTTALQKIIP YVGQTRRVEV LGFSEFERKA YFHKYFVNES
NAIDAFRLVL SNPVLLTLCE VPWVCWLVCT CLKKQMEQGG ELSLTSQTTT ALCLKYLSLT
IPGQHMRTQL RALCSLAAEG ICQRRTLFSE SNLCKQGLAE DAIATFLKIG ILQKQYSSLS
YSFAHLCLQE FFAAMSYILE DSDERCGGME FKRTVETLIE VYGRHTLFEE PTVHFLFGLV
NAQGMREMKK IFDCKLPLGI ELKMLRSTLG NPPYQHHLGL LHCLYESQEE VLLTYVLCNL
HLTGPDKNYK EATVSQTNVK HLVIQTDMEL MVVTFCIQFC YHVMSLRVNM EGQQGHNLTV
ASTVLYRWTP ITDASWKILF YNLKFARNLK GLDLSGNPLN YSAVQYLCKA LRYPGWQLKN
LWLVDCHLTS TYCSLLASLL RDHPSLTELD LQLNDLGDDG VRMLCLGFRN HAGNLSILRL
DQASLSAQVI TELRTLEAEN LKLHISSTWK PHVMIPTKNK DKEEMSDSPK SFKQQRKQSE
DKHVESLWTD NDFWGPTGPV ATEVVDREGN QYRVQLPMAG CYHCPSTGLH FVVTRAVTIE
IEFCAWSQYL DETFLKHSHM VVGPLFDIKA EQGAVTAVYL PHFVALQEGI VDSSLFHVAH
FQEHGMVLET PARVEQHYAV LENPSFSPVG ILLRMIPAVG HFIPITSITL IYYHLYHKGV
TFHLYLVPND CTIRKAIDDE EMKFQFVRIN KPPPVDALYI GSRYIVSATR KVEIFPKELE
LCYRSPEKSQ LFSEIYVRDM GSGIKLQLRD KGHKKLKWEA FLKPGDLRPA LPRIASTTND
APFFQHFVEQ HREQLVARVT SVDPILDKLH GLVLSEESYE AVRAETTNQD KMRKLFSLSR
SWSQACKYQF YQALKDTHPH LMMDLFVNSD KGTRSLGDPD FGELSD
//
