ID Q0H0G8_STAAU Unreviewed; 205 AA.
AC Q0H0G8; A0A1E8X2U4;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=AAA family ATPase {ECO:0000313|EMBL:MVH48562.1};
DE SubName: Full=Deoxyguanosine kinase {ECO:0000313|EMBL:ABD37700.1};
DE EC=2.7.1.113 {ECO:0000313|EMBL:ABD37700.1, ECO:0000313|EMBL:CAA4389539.1};
DE SubName: Full=Deoxynucleoside kinase {ECO:0000313|EMBL:AWW95750.1};
GN Name=dgk {ECO:0000313|EMBL:ABD37700.1};
GN ORFNames=BN1321_130045 {ECO:0000313|EMBL:CRI07865.1}, C7M54_03780
GN {ECO:0000313|EMBL:AWW95750.1}, CV021_09355
GN {ECO:0000313|EMBL:PPJ73860.1}, DD547_00528
GN {ECO:0000313|EMBL:AXP70402.1}, EP54_13025
GN {ECO:0000313|EMBL:KMR56034.1}, EQ90_07195
GN {ECO:0000313|EMBL:KMR36717.1}, FAF17_03265
GN {ECO:0000313|EMBL:TJY12804.1}, G6W63_01140
GN {ECO:0000313|EMBL:NGW86304.1}, GO782_07995
GN {ECO:0000313|EMBL:MVH48562.1}, GO814_00230
GN {ECO:0000313|EMBL:MVK33578.1}, GO942_12690
GN {ECO:0000313|EMBL:MVM11520.1}, GQX37_06445
GN {ECO:0000313|EMBL:NUY12186.1}, GZ067_07005
GN {ECO:0000313|EMBL:QID97435.1}, GZ156_05840
GN {ECO:0000313|EMBL:NDQ60057.1}, NCTC13131_01027
GN {ECO:0000313|EMBL:CAD7353541.1}, NCTC6133_00659
GN {ECO:0000313|EMBL:SUK33661.1}, NCTC7878_01182
GN {ECO:0000313|EMBL:SPZ97792.1}, NCTC7972_01377
GN {ECO:0000313|EMBL:SUK17859.1}, SAMEA2078260_02184
GN {ECO:0000313|EMBL:CAA4389539.1}, SAMEA2078588_02171
GN {ECO:0000313|EMBL:CAA6110100.1}, SAMEA2080344_02226
GN {ECO:0000313|EMBL:CAA6375985.1}, SAMEA2081063_02176
GN {ECO:0000313|EMBL:CAA4697341.1}, SAMEA4008575_00549
GN {ECO:0000313|EMBL:CAC5778215.1}, SAMEA70146418_00929
GN {ECO:0000313|EMBL:CAC8204189.1};
OS Staphylococcus aureus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:ABD37700.1};
RN [1] {ECO:0000313|EMBL:ABD37700.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DVI CCM 885 {ECO:0000313|EMBL:ABD37700.1};
RA Sandrini M.P.B., Clausen A.R., Piskur J.;
RT "Bacterial deoxyribonucleoside kinases.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABD37700.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DVI CCM 885 {ECO:0000313|EMBL:ABD37700.1};
RX PubMed=17526755; DOI=10.1128/AAC.00081-07;
RA Sandrini M.P., Shannon O., Clausen A.R., Bjorck L., Piskur J.;
RT "Deoxyribonucleoside kinases activate nucleoside antibiotics in severely
RT pathogenic bacteria.";
RL Antimicrob. Agents Chemother. 51:2726-2732(2007).
RN [3] {ECO:0000313|EMBL:ABD37700.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DVI CCM 885 {ECO:0000313|EMBL:ABD37700.1};
RX PubMed=17615154; DOI=10.1093/jac/dkm240;
RA Sandrini M.P., Clausen A.R., On S.L., Aarestrup F.M., Munch-Petersen B.,
RA Piskur J.;
RT "Nucleoside analogues are activated by bacterial deoxyribonucleoside
RT kinases in a species-specific manner.";
RL J. Antimicrob. Chemother. 60:510-520(2007).
RN [4] {ECO:0000313|EMBL:KMR36717.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA15 {ECO:0000313|EMBL:KMR36717.1}, and M121
RC {ECO:0000313|EMBL:KMR56034.1};
RX PubMed=26048971; DOI=10.1093/infdis/jiv320;
RA Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J., Xing G.,
RA Rincon S., Smith H., Panesso D., Ryan C., Smith D.P., Guzman M., Zurita J.,
RA Sebra R., Deikus G., Nolan R.L., Tenover F.C., Weinstock G.M.,
RA Robinson D.A., Arias C.A.;
RT "Parallel Epidemics of Community-Associated Methicillin-Resistant
RT Staphylococcus aureus USA300 Infection in North and South America.";
RL J. Infect. Dis. 212:1874-1882(2015).
RN [5] {ECO:0000313|EMBL:CRI07865.1, ECO:0000313|Proteomes:UP000039437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH1 {ECO:0000313|EMBL:CRI07865.1,
RC ECO:0000313|Proteomes:UP000039437};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:PPJ73860.1, ECO:0000313|Proteomes:UP000238775}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G703N2B1 {ECO:0000313|EMBL:PPJ73860.1,
RC ECO:0000313|Proteomes:UP000238775};
RA Founou R.C., Founou L., Allam M., Ismail A., Essack S.Y.;
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AWW95750.1, ECO:0000313|Proteomes:UP000249552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMRSA-3 {ECO:0000313|EMBL:AWW95750.1,
RC ECO:0000313|Proteomes:UP000249552};
RA McClure J.M., Shideler S.M., Zhang K.;
RT "Complete genome sequence of Canadian epidemic MRSA strain CMRSA3.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000249913, ECO:0000313|Proteomes:UP000254224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC6133 {ECO:0000313|EMBL:SUK33661.1,
RC ECO:0000313|Proteomes:UP000255091}, NCTC7878
RC {ECO:0000313|EMBL:SPZ97792.1, ECO:0000313|Proteomes:UP000249913}, and
RC NCTC7972 {ECO:0000313|EMBL:SUK17859.1,
RC ECO:0000313|Proteomes:UP000254224};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AXP70402.1, ECO:0000313|Proteomes:UP000259766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=64 {ECO:0000313|EMBL:AXP70402.1,
RC ECO:0000313|Proteomes:UP000259766};
RA Chako K., Divya B., Pak T., Sause W., Kumar K., Sebra R., Deikus G.,
RA Attie O., Rose H., Lewis M., Li Y., Bashir A., Kasarskis A., Schadt E.,
RA Richardson A.R., Torres V., Shopsin B.;
RT "Colonizing and infecting subclones diverge during Staphylococcus aureus
RT infection.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:AXP70402.1, ECO:0000313|Proteomes:UP000259766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=64 {ECO:0000313|EMBL:AXP70402.1,
RC ECO:0000313|Proteomes:UP000259766};
RA Chako K.I., Sullivan M.J., van Bakel H.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:TJY12804.1, ECO:0000313|Proteomes:UP000306447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=42 {ECO:0000313|EMBL:TJY12804.1,
RC ECO:0000313|Proteomes:UP000306447};
RA Fouts D., Sutton G., Singh I., Nguyen K.;
RT "WGS of SAMN11458133.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|Proteomes:UP000442194, ECO:0000313|Proteomes:UP000471199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S_1081.LBCF.DN {ECO:0000313|EMBL:MVM11520.1,
RC ECO:0000313|Proteomes:UP000478867}, S_2062.LAUP.DI
RC {ECO:0000313|EMBL:MVK33578.1, ECO:0000313|Proteomes:UP000471199}, and
RC S_3122.LTHB.DN {ECO:0000313|EMBL:MVH48562.1,
RC ECO:0000313|Proteomes:UP000442194};
RA Stine O.C.;
RT "Implementation of targeted gown and glove precautions to prevent
RT Staphylococcus aureus acquisition in community-based nursing homes.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|Proteomes:UP000442696, ECO:0000313|Proteomes:UP000443506}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MOS105 {ECO:0000313|EMBL:CAC8204189.1,
RC ECO:0000313|Proteomes:UP000507112}, NCTC13131
RC {ECO:0000313|EMBL:CAD7353541.1}, SG160 {ECO:0000313|EMBL:CAC5778215.1,
RC ECO:0000313|Proteomes:UP000505390}, T012_N10_C04
RC {ECO:0000313|EMBL:CAA6110100.1, ECO:0000313|Proteomes:UP000459702},
RC T012_N16_C08 {ECO:0000313|EMBL:CAA4389539.1,
RC ECO:0000313|Proteomes:UP000442696}, T065_N03_C06
RC {ECO:0000313|EMBL:CAA4697341.1, ECO:0000313|Proteomes:UP000443506},
RC and T197_A02_C01 {ECO:0000313|EMBL:CAA6375985.1,
RC ECO:0000313|Proteomes:UP000459586};
RG Pathogen Informatics;
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:NUY12186.1, ECO:0000313|Proteomes:UP000547874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UE1097 {ECO:0000313|EMBL:NUY12186.1,
RC ECO:0000313|Proteomes:UP000547874};
RX PubMed=32562543;
RA Castro B.E., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V., Rios R.,
RA Hernandez A.K., Rincon S., Cubides P., Forero E., Dinh A., Seas C.,
RA Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT "Detection of heterogeneous vancomycin intermediate resistance in MRSA
RT isolates from Latin America.";
RL J. Antimicrob. Chemother. 0:0-0(2020).
RN [15] {ECO:0000313|EMBL:NDQ60057.1, ECO:0000313|Proteomes:UP000462022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=67-013 {ECO:0000313|EMBL:NDQ60057.1,
RC ECO:0000313|Proteomes:UP000462022};
RA Little S.V., Hillhouse A.E., Cohen N.D., Lawhon S.D., Bryan L.K.;
RT "Analysis of Virulence and Antimicrobial Resistance Gene Carriage in
RT Staphylococcus aureus Infections in Equids Using Whole Genome Sequencing.";
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:NGW86304.1, ECO:0000313|Proteomes:UP000478593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UA786 {ECO:0000313|EMBL:NGW86304.1,
RC ECO:0000313|Proteomes:UP000478593};
RA Castro-Cardozo B., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V.,
RA Rios R., Hernandez A., Rincon S.L., Cubides P., Forero E., Dinh A.,
RA Seas C., Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT "Detection of Heterogeneous Vancomycin Intermediate Resistance in
RT Methicillin Resistant Staphylococcus aureus Isolates from Latin-America.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:QID97435.1, ECO:0000313|Proteomes:UP000501532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA1428 {ECO:0000313|EMBL:QID97435.1,
RC ECO:0000313|Proteomes:UP000501532};
RA Lippolis J.;
RT "DNA sequencing of a Staphylococcus aureus strain isolated from an
RT intramammary infection in a dairy cow.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DCK/DGK family.
CC {ECO:0000256|ARBA:ARBA00007420}.
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DR EMBL; DQ384606; ABD37700.1; -; Genomic_DNA.
DR EMBL; CP029685; AWW95750.1; -; Genomic_DNA.
DR EMBL; CP031670; AXP70402.1; -; Genomic_DNA.
DR EMBL; CACTQT010000013; CAA4389539.1; -; Genomic_DNA.
DR EMBL; CACTWD010000014; CAA4697341.1; -; Genomic_DNA.
DR EMBL; CACUNS010000014; CAA6110100.1; -; Genomic_DNA.
DR EMBL; CACURZ010000014; CAA6375985.1; -; Genomic_DNA.
DR EMBL; CAIGXB010000001; CAC5778215.1; -; Genomic_DNA.
DR EMBL; CAIIGD010000002; CAC8204189.1; -; Genomic_DNA.
DR EMBL; UAUZ02000002; CAD7353541.1; -; Genomic_DNA.
DR EMBL; CVOQ01000005; CRI07865.1; -; Genomic_DNA.
DR EMBL; LALJ01000012; KMR36717.1; -; Genomic_DNA.
DR EMBL; LALQ01000066; KMR56034.1; -; Genomic_DNA.
DR EMBL; WPRT01000128; MVH48562.1; -; Genomic_DNA.
DR EMBL; WPTS01000002; MVK33578.1; -; Genomic_DNA.
DR EMBL; WPXC01000032; MVM11520.1; -; Genomic_DNA.
DR EMBL; JAAFKS010000008; NDQ60057.1; -; Genomic_DNA.
DR EMBL; JAALUV010000003; NGW86304.1; -; Genomic_DNA.
DR EMBL; JAANEC010000067; NUY12186.1; -; Genomic_DNA.
DR EMBL; PGWZ01000395; PPJ73860.1; -; Genomic_DNA.
DR EMBL; CP048431; QID97435.1; -; Genomic_DNA.
DR EMBL; UAUX01000006; SPZ97792.1; -; Genomic_DNA.
DR EMBL; UHAI01000002; SUK17859.1; -; Genomic_DNA.
DR EMBL; UHAP01000001; SUK33661.1; -; Genomic_DNA.
DR EMBL; SULE01000061; TJY12804.1; -; Genomic_DNA.
DR RefSeq; WP_001039519.1; NZ_WWFR01000001.1.
DR ChEMBL; CHEMBL5322; -.
DR KEGG; sams:NI36_02770; -.
DR PATRIC; fig|1280.10758.peg.516; -.
DR OMA; IEEWSFQ; -.
DR Proteomes; UP000039437; Unassembled WGS sequence.
DR Proteomes; UP000238775; Unassembled WGS sequence.
DR Proteomes; UP000249552; Chromosome.
DR Proteomes; UP000249913; Unassembled WGS sequence.
DR Proteomes; UP000251686; Unassembled WGS sequence.
DR Proteomes; UP000254224; Unassembled WGS sequence.
DR Proteomes; UP000255091; Unassembled WGS sequence.
DR Proteomes; UP000259766; Chromosome.
DR Proteomes; UP000306447; Unassembled WGS sequence.
DR Proteomes; UP000442194; Unassembled WGS sequence.
DR Proteomes; UP000442696; Unassembled WGS sequence.
DR Proteomes; UP000443506; Unassembled WGS sequence.
DR Proteomes; UP000459586; Unassembled WGS sequence.
DR Proteomes; UP000459702; Unassembled WGS sequence.
DR Proteomes; UP000462022; Unassembled WGS sequence.
DR Proteomes; UP000471199; Unassembled WGS sequence.
DR Proteomes; UP000478593; Unassembled WGS sequence.
DR Proteomes; UP000478867; Unassembled WGS sequence.
DR Proteomes; UP000501532; Chromosome.
DR Proteomes; UP000505390; Unassembled WGS sequence.
DR Proteomes; UP000507112; Unassembled WGS sequence.
DR Proteomes; UP000547874; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004138; F:deoxyguanosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01673; dNK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513:SF46; DEOXYGUANOSINE KINASE; 1.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000313|EMBL:ABD37700.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Transferase {ECO:0000313|EMBL:ABD37700.1}.
FT DOMAIN 6..193
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 81
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 10..18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 133..137
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ SEQUENCE 205 AA; 24153 MW; 04216450F6B7890D CRC64;
MNKPFIAIEG PIGVGKSSLA HKLSQTLDFY EEKEIITENP FLSDFYEDIS KWSFQTEMFF
LCNRYKQFQD VTQLNQGVVS DYHIHKNKIF AKNTLSSVEF QKFSKIYDIL TEDMIMPNMI
IFLDADLDVL KSRIAKRNRS FEHQIEDEYL LKLKKDYREY YESLQSNGSN VVLIDTTSID
FLKNEQDYED ILHIILPMIG DITNE
//
