ID Q0H297_HARAX Unreviewed; 95 AA.
AC Q0H297;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Engrailed {ECO:0000313|EMBL:ABC59250.1};
DE Flags: Fragment;
OS Harmonia axyridis (Multicolored Asian lady beetle) (Coccinella axyridis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Coccinelloidea; Coccinellidae; Coccinellinae; Coccinellini; Harmonia.
OX NCBI_TaxID=115357 {ECO:0000313|EMBL:ABC59250.1};
RN [1] {ECO:0000313|EMBL:ABC59250.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16790405; DOI=10.1098/rspb.2006.3497;
RA Peel A.D., Telford M.J., Akam M.;
RT "The evolution of hexapod engrailed-family genes: evidence for conservation
RT and concerted evolution.";
RL Proc. R. Soc. B 273:1733-1742(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family.
CC {ECO:0000256|ARBA:ARBA00010896}.
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DR EMBL; DQ323901; ABC59250.1; -; mRNA.
DR AlphaFoldDB; Q0H297; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24341; HOMEOBOX PROTEIN ENGRAILED; 1.
DR PANTHER; PTHR24341:SF6; HOMEOBOX PROTEIN INVECTED-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 24..84
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 26..85
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABC59250.1"
FT NON_TER 95
FT /evidence="ECO:0000313|EMBL:ABC59250.1"
SQ SEQUENCE 95 AA; 11254 MW; 54445EEF9FF4659A CRC64;
TRYSDRPSSG PRSRRMKKPT KPSNEEKRPR TAFSSAQLQR LKHEFNENRY LTERRRQQLS
AELGLNEAQI KIWFQNKRAK IKKSSSEKNP LALQL
//
