ID Q0H2B7_9STRA Unreviewed; 369 AA.
AC Q0H2B7;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Tubulin beta chain {ECO:0000256|RuleBase:RU000352};
DE Flags: Fragment;
OS Thraustochytrium aureum.
OC Eukaryota; Sar; Stramenopiles; Bigyra; Labyrinthulomycetes;
OC Thraustochytrida; Thraustochytriaceae; Thraustochytrium.
OX NCBI_TaxID=42467 {ECO:0000313|EMBL:ABC61491.1};
RN [1] {ECO:0000313|EMBL:ABC61491.1}
RP NUCLEOTIDE SEQUENCE.
RA Tsui K.M., Marshall W., Berbee M.L., Yokoyama R., Honda D.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABC61491.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18977305; DOI=10.1016/j.ympev.2008.09.027;
RA Tsui C.K., Marshall W., Yokoyama R., Honda D., Lippmeier J.C., Craven K.D.,
RA Peterson P.D., Berbee M.L.;
RT "Labyrinthulomycetes phylogeny and its implications for the evolutionary
RT loss of chloroplasts and gain of ectoplasmic gliding.";
RL Mol. Phylogenet. Evol. 50:129-140(2009).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; DQ323164; ABC61491.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0H2B7; -.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02187; beta_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002453; Beta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF429; TUBULIN BETA-1 CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01163; BETATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 10..207
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 209..346
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABC61491.1"
FT NON_TER 369
FT /evidence="ECO:0000313|EMBL:ABC61491.1"
SQ SEQUENCE 369 AA; 41227 MW; 29FA13B497A55C90 CRC64;
GDSDLQLERI NVYFNEATGG RYVPRAILMD LEPGTMDSVR AGPFGQIFRP DNFVFGQSGA
GNNWAKGHYT EGAELIDSVL DVVRKEAESC DCLQGFQITH SLGGGTGSGM GTLLISKIRE
EYPDRIMLTF SIVPSPKVSD TVVEPYNATL SVHQLVENAD EVMVLDNEAL YDICFRTLKL
TTPTYGDLNH LVCAAMSGCT CCLRFPGQLN SDLRKLAVNL IPFPRLHFFM IGFSPLTSRG
SQQYRALTVP ELTQQAFDAK NMMCAADPRH GRYLTASTLF RGRMSTKEVD EQMLNIQNKN
SSYFVEWIPN NIKSSVCDIP PKGLKMSCTF VGNTTAVQEM FKRVSEQFTS MFRRKAFLHW
YTGEGMDEM
//
