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Database: UniProt
Entry: Q0H2G3_DANRE
LinkDB: Q0H2G3_DANRE
Original site: Q0H2G3_DANRE 
ID   Q0H2G3_DANRE            Unreviewed;       513 AA.
AC   Q0H2G3; A6XAC4; F6PDD0;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   SubName: Full=Aldehyde dehydrogenase 1 family member A3 {ECO:0000313|EMBL:ABP48748.1};
DE   SubName: Full=Aldehyde dehydrogenase 1 family, member A3 {ECO:0000313|Ensembl:ENSDARP00000055592};
DE   SubName: Full=Aldehyde dehydrogenase family 1 member A3 {ECO:0000313|RefSeq:NP_001038210.1};
DE            EC=1.2.1.5 {ECO:0000313|RefSeq:NP_001038210.1};
DE   SubName: Full=RALDH3 {ECO:0000313|EMBL:AAZ84926.1};
DE   SubName: Full=Retinaldehyde dehydrogenase family 1 subfamily A3 {ECO:0000313|EMBL:ABC17784.1};
GN   Name=RALDH3 {ECO:0000313|RefSeq:NP_001038210.1};
GN   Synonyms=raldh3 {ECO:0000313|EMBL:ABP48748.1};
GN   OrderedLocusNames=aldh1a3 {ECO:0000313|Ensembl:ENSDARP00000055592,
GN   ECO:0000313|RefSeq:NP_001038210.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-061128-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAZ84926.1};
RN   [1] {ECO:0000313|EMBL:AAZ84926.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lupo G., Harris W.A.;
RT   "Dorsoventral patterning of the zebrafish eye.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABC17784.1, ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16925675; DOI=10.1111/j.1525-142X.2006.00113.x;
RA   Canestro C., Postlethwait J.H., Gonzalez-Duarte R., Albalat R.;
RT   "Is retinoic acid genetic machinery a chordate innovation?";
RL   Evol. Dev. 8:394-406(2006).
RN   [3] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16705083;
RA   Schlueter P.J., Royer T., Farah M.H., Laser B., Chan S.J., Steiner D.F.,
RA   Duan C.;
RT   "Gene duplication and functional divergence of the zebrafish insulin-like
RT   growth factor 1 receptors.";
RL   FASEB J. 20:1230-1232(2006).
RN   [4] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18178530;
RA   Pittlik S., Domingues S., Meyer A., Begemann G.;
RT   "Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in
RT   teleosts.";
RL   Gene Expr. Patterns 8:141-147(2008).
RN   [5] {ECO:0000313|EMBL:ABP48748.1, ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18262854; DOI=10.1016/j.gep.2007.12.007;
RA   Liang D., Zhang M., Bao J., Zhang L., Xu X., Gao X., Zhao Q.;
RT   "Expressions of Raldh3 and Raldh4 during zebrafish early development.";
RL   Gene Expr. Patterns 8:248-253(2008).
RN   [6] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19132125; DOI=10.1242/dmm.001164;
RA   Dutton K., Abbas L., Spencer J., Brannon C., Mowbray C., Nikaido M.,
RA   Kelsh R.N., Whitfield T.T.;
RT   "A zebrafish model for Waardenburg syndrome type IV reveals diverse roles
RT   for Sox10 in the otic vesicle.";
RL   Dis. Model. Mech. 2:68-83(2009).
RN   [7] {ECO:0000313|Ensembl:ENSDARP00000055592}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000055592};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [8] {ECO:0000313|Ensembl:ENSDARP00000055592, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000055592};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [9] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26893342;
RA   Valdivia L.E., Lamb D.B., Horner W., Wierzbicki C., Tafessu A.,
RA   Williams A.M., Gestri G., Krasnow A.M., Vleeshouwer-Neumann T.S.,
RA   Givens M., Young R.M., Lawrence L.M., Stickney H.L., Hawkins T.A.,
RA   Schwarz Q.P., Cavodeassi F., Wilson S.W., Cerveny K.L.;
RT   "Antagonism between Gdf6a and retinoic acid pathways controls timing of
RT   retinal neurogenesis and growth of the eye in zebrafish.";
RL   Development 143:1087-1098(2016).
RN   [10] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26950095;
RA   Braasch I., Gehrke A.R., Smith J.J., Kawasaki K., Manousaki T.,
RA   Pasquier J., Amores A., Desvignes T., Batzel P., Catchen J., Berlin A.M.,
RA   Campbell M.S., Barrell D., Martin K.J., Mulley J.F., Ravi V., Lee A.P.,
RA   Nakamura T., Chalopin D., Fan S., Wcisel D., Canestro C., Sydes J.,
RA   Beaudry F.E., Sun Y., Hertel J., Beam M.J., Fasold M., Ishiyama M.,
RA   Johnson J., Kehr S., Lara M., Letaw J.H., Litman G.W., Litman R.T.,
RA   Mikami M., Ota T., Saha N.R., Williams L., Stadler P.F., Wang H.,
RA   Taylor J.S., Fontenot Q., Ferrara A., Searle S.M., Aken B., Yandell M.,
RA   Schneider I., Yoder J.A., Volff J.N., Meyer A., Amemiya C.T., Venkatesh B.,
RA   Holland P.W., Guiguen Y., Bobe J., Shubin N.H., Di Palma F., Alfoldi J.,
RA   Lindblad-Toh K., Postlethwait J.H.;
RT   "The spotted gar genome illuminates vertebrate evolution and facilitates
RT   human-teleost comparisons.";
RL   Nat. Genet. 48:427-437(2016).
RN   [11] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28085063;
RA   Wang W.D., Hsu H.J., Li Y.F., Wu C.Y.;
RT   "Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic
RT   Retinal Photoreceptor Cells from Exposure to Paclobutrazol.";
RL   Int. J. Mol. Sci. 18:E130-E130(2017).
RN   [12] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29625437;
RA   Cao M., Ouyang J., Guo J., Lin S., Chen S.;
RT   "Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic
RT   Fissure.";
RL   Invest. Ophthalmol. Vis. Sci. 59:1167-1177(2018).
RN   [13] {ECO:0000313|RefSeq:NP_001038210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30695021;
RA   Turner K.J., Hoyle J., Valdivia L.E., Cerveny K.L., Hart W., Mangoli M.,
RA   Geisler R., Rees M., Houart C., Poole R.J., Wilson S.W., Gestri G.;
RT   "Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure
RT   of cells to transition from proliferation to differentiation, retinal
RT   coloboma and midline axon guidance deficits.";
RL   PLoS ONE 14:e0211073-e0211073(2019).
RN   [14] {ECO:0000313|RefSeq:NP_001038210.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CABZ01067598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01067605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ105978; AAZ84926.1; -; mRNA.
DR   EMBL; DQ300198; ABC17784.1; -; mRNA.
DR   EMBL; EF375713; ABP48748.1; -; mRNA.
DR   RefSeq; NP_001038210.1; NM_001044745.1.
DR   STRING; 7955.ENSDARP00000055592; -.
DR   PaxDb; 7955-ENSDARP00000055592; -.
DR   Ensembl; ENSDART00000055593; ENSDARP00000055592; ENSDARG00000076933.
DR   Ensembl; ENSDART00000055593.8; ENSDARP00000055592.5; ENSDARG00000076933.5.
DR   GeneID; 751785; -.
DR   KEGG; dre:751785; -.
DR   CTD; 220; -.
DR   ZFIN; ZDB-GENE-061128-2; aldh1a3.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   OMA; MYGFEDY; -.
DR   OrthoDB; 2291791at2759; -.
DR   TreeFam; TF300455; -.
DR   BRENDA; 1.2.1.36; 928.
DR   Reactome; R-DRE-5365859; RA biosynthesis pathway.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000076933; Expressed in crista ampullaris and 20 other cell types or tissues.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF209; ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN          41..503
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        280
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   513 AA;  55880 MW;  4D3AC9B0E39659F2 CRC64;
     MAQNGTIENG DSRNTSPPPL PQPVKITEIK HTKIFINNEW HTSSKGKQFP TINPATGVKI
     CDIEEADKAD VDEAVKAAKA AGQRGSVWRR MDASSRGRLL NRLADLLERE RAVLATLESK
     DTGKPFLHAF FVDLDGSIKT LRYYAGWTDK IHGKTMPVDE NFVCFTKHEP IGVCGAIIPW
     NFPLLMLMWK IAPALACGNT VVLKPAEQTP LTALHVAALI KEAGFPPGVV NVVPGFGPTA
     GAAIAGHMNI DKLAFTGSTE VGQLVKAAAA SSNLKRVTLE LGGKNPCIVF ADSDLQLAVE
     ETQKGAFFNQ GQACTAASRV YVQEPVYEEF VRLSVERAKN IVIGDPMEPR TSHGPQIDQH
     QFEKILALVD SGKKEGAKLE FGGCAVEDRG LFIHPTIFSD VKDHMRIAKE EIFGPVQCIM
     KFECQQDVID RANSSQFGLT AAVFTRDVQR AMSVSAALEA GTVWVNCYNA LHAQTPFGGY
     KMSGNGRELG EYALAEYTEV KAITIKLSEQ LRL
//
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