ID Q0H2G3_DANRE Unreviewed; 513 AA.
AC Q0H2G3; A6XAC4; F6PDD0;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 24-JAN-2024, entry version 129.
DE SubName: Full=Aldehyde dehydrogenase 1 family member A3 {ECO:0000313|EMBL:ABP48748.1};
DE SubName: Full=Aldehyde dehydrogenase 1 family, member A3 {ECO:0000313|Ensembl:ENSDARP00000055592};
DE SubName: Full=Aldehyde dehydrogenase family 1 member A3 {ECO:0000313|RefSeq:NP_001038210.1};
DE EC=1.2.1.5 {ECO:0000313|RefSeq:NP_001038210.1};
DE SubName: Full=RALDH3 {ECO:0000313|EMBL:AAZ84926.1};
DE SubName: Full=Retinaldehyde dehydrogenase family 1 subfamily A3 {ECO:0000313|EMBL:ABC17784.1};
GN Name=RALDH3 {ECO:0000313|RefSeq:NP_001038210.1};
GN Synonyms=raldh3 {ECO:0000313|EMBL:ABP48748.1};
GN OrderedLocusNames=aldh1a3 {ECO:0000313|Ensembl:ENSDARP00000055592,
GN ECO:0000313|RefSeq:NP_001038210.1,
GN ECO:0000313|ZFIN:ZDB-GENE-061128-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAZ84926.1};
RN [1] {ECO:0000313|EMBL:AAZ84926.1}
RP NUCLEOTIDE SEQUENCE.
RA Lupo G., Harris W.A.;
RT "Dorsoventral patterning of the zebrafish eye.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABC17784.1, ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16925675; DOI=10.1111/j.1525-142X.2006.00113.x;
RA Canestro C., Postlethwait J.H., Gonzalez-Duarte R., Albalat R.;
RT "Is retinoic acid genetic machinery a chordate innovation?";
RL Evol. Dev. 8:394-406(2006).
RN [3] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16705083;
RA Schlueter P.J., Royer T., Farah M.H., Laser B., Chan S.J., Steiner D.F.,
RA Duan C.;
RT "Gene duplication and functional divergence of the zebrafish insulin-like
RT growth factor 1 receptors.";
RL FASEB J. 20:1230-1232(2006).
RN [4] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18178530;
RA Pittlik S., Domingues S., Meyer A., Begemann G.;
RT "Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in
RT teleosts.";
RL Gene Expr. Patterns 8:141-147(2008).
RN [5] {ECO:0000313|EMBL:ABP48748.1, ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18262854; DOI=10.1016/j.gep.2007.12.007;
RA Liang D., Zhang M., Bao J., Zhang L., Xu X., Gao X., Zhao Q.;
RT "Expressions of Raldh3 and Raldh4 during zebrafish early development.";
RL Gene Expr. Patterns 8:248-253(2008).
RN [6] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19132125; DOI=10.1242/dmm.001164;
RA Dutton K., Abbas L., Spencer J., Brannon C., Mowbray C., Nikaido M.,
RA Kelsh R.N., Whitfield T.T.;
RT "A zebrafish model for Waardenburg syndrome type IV reveals diverse roles
RT for Sox10 in the otic vesicle.";
RL Dis. Model. Mech. 2:68-83(2009).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000055592}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000055592};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [8] {ECO:0000313|Ensembl:ENSDARP00000055592, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000055592};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26893342;
RA Valdivia L.E., Lamb D.B., Horner W., Wierzbicki C., Tafessu A.,
RA Williams A.M., Gestri G., Krasnow A.M., Vleeshouwer-Neumann T.S.,
RA Givens M., Young R.M., Lawrence L.M., Stickney H.L., Hawkins T.A.,
RA Schwarz Q.P., Cavodeassi F., Wilson S.W., Cerveny K.L.;
RT "Antagonism between Gdf6a and retinoic acid pathways controls timing of
RT retinal neurogenesis and growth of the eye in zebrafish.";
RL Development 143:1087-1098(2016).
RN [10] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26950095;
RA Braasch I., Gehrke A.R., Smith J.J., Kawasaki K., Manousaki T.,
RA Pasquier J., Amores A., Desvignes T., Batzel P., Catchen J., Berlin A.M.,
RA Campbell M.S., Barrell D., Martin K.J., Mulley J.F., Ravi V., Lee A.P.,
RA Nakamura T., Chalopin D., Fan S., Wcisel D., Canestro C., Sydes J.,
RA Beaudry F.E., Sun Y., Hertel J., Beam M.J., Fasold M., Ishiyama M.,
RA Johnson J., Kehr S., Lara M., Letaw J.H., Litman G.W., Litman R.T.,
RA Mikami M., Ota T., Saha N.R., Williams L., Stadler P.F., Wang H.,
RA Taylor J.S., Fontenot Q., Ferrara A., Searle S.M., Aken B., Yandell M.,
RA Schneider I., Yoder J.A., Volff J.N., Meyer A., Amemiya C.T., Venkatesh B.,
RA Holland P.W., Guiguen Y., Bobe J., Shubin N.H., Di Palma F., Alfoldi J.,
RA Lindblad-Toh K., Postlethwait J.H.;
RT "The spotted gar genome illuminates vertebrate evolution and facilitates
RT human-teleost comparisons.";
RL Nat. Genet. 48:427-437(2016).
RN [11] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28085063;
RA Wang W.D., Hsu H.J., Li Y.F., Wu C.Y.;
RT "Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic
RT Retinal Photoreceptor Cells from Exposure to Paclobutrazol.";
RL Int. J. Mol. Sci. 18:E130-E130(2017).
RN [12] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29625437;
RA Cao M., Ouyang J., Guo J., Lin S., Chen S.;
RT "Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic
RT Fissure.";
RL Invest. Ophthalmol. Vis. Sci. 59:1167-1177(2018).
RN [13] {ECO:0000313|RefSeq:NP_001038210.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30695021;
RA Turner K.J., Hoyle J., Valdivia L.E., Cerveny K.L., Hart W., Mangoli M.,
RA Geisler R., Rees M., Houart C., Poole R.J., Wilson S.W., Gestri G.;
RT "Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure
RT of cells to transition from proliferation to differentiation, retinal
RT coloboma and midline axon guidance deficits.";
RL PLoS ONE 14:e0211073-e0211073(2019).
RN [14] {ECO:0000313|RefSeq:NP_001038210.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CABZ01067598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01067605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ105978; AAZ84926.1; -; mRNA.
DR EMBL; DQ300198; ABC17784.1; -; mRNA.
DR EMBL; EF375713; ABP48748.1; -; mRNA.
DR RefSeq; NP_001038210.1; NM_001044745.1.
DR STRING; 7955.ENSDARP00000055592; -.
DR PaxDb; 7955-ENSDARP00000055592; -.
DR Ensembl; ENSDART00000055593; ENSDARP00000055592; ENSDARG00000076933.
DR Ensembl; ENSDART00000055593.8; ENSDARP00000055592.5; ENSDARG00000076933.5.
DR GeneID; 751785; -.
DR KEGG; dre:751785; -.
DR CTD; 220; -.
DR ZFIN; ZDB-GENE-061128-2; aldh1a3.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_0_1_1; -.
DR OMA; MYGFEDY; -.
DR OrthoDB; 2291791at2759; -.
DR TreeFam; TF300455; -.
DR BRENDA; 1.2.1.36; 928.
DR Reactome; R-DRE-5365859; RA biosynthesis pathway.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000076933; Expressed in crista ampullaris and 20 other cell types or tissues.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF209; ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 41..503
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 513 AA; 55880 MW; 4D3AC9B0E39659F2 CRC64;
MAQNGTIENG DSRNTSPPPL PQPVKITEIK HTKIFINNEW HTSSKGKQFP TINPATGVKI
CDIEEADKAD VDEAVKAAKA AGQRGSVWRR MDASSRGRLL NRLADLLERE RAVLATLESK
DTGKPFLHAF FVDLDGSIKT LRYYAGWTDK IHGKTMPVDE NFVCFTKHEP IGVCGAIIPW
NFPLLMLMWK IAPALACGNT VVLKPAEQTP LTALHVAALI KEAGFPPGVV NVVPGFGPTA
GAAIAGHMNI DKLAFTGSTE VGQLVKAAAA SSNLKRVTLE LGGKNPCIVF ADSDLQLAVE
ETQKGAFFNQ GQACTAASRV YVQEPVYEEF VRLSVERAKN IVIGDPMEPR TSHGPQIDQH
QFEKILALVD SGKKEGAKLE FGGCAVEDRG LFIHPTIFSD VKDHMRIAKE EIFGPVQCIM
KFECQQDVID RANSSQFGLT AAVFTRDVQR AMSVSAALEA GTVWVNCYNA LHAQTPFGGY
KMSGNGRELG EYALAEYTEV KAITIKLSEQ LRL
//