ID Q0K278_CUPNH Unreviewed; 419 AA.
AC Q0K278;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Putative peptidase, M20A subfamily {ECO:0000313|EMBL:CAJ95896.1};
DE EC=3.4.-.- {ECO:0000313|EMBL:CAJ95896.1};
GN OrderedLocusNames=H16_B1105 {ECO:0000313|EMBL:CAJ95896.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ95896.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ95896.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; AM260480; CAJ95896.1; -; Genomic_DNA.
DR RefSeq; WP_011617012.1; NZ_CP039288.1.
DR AlphaFoldDB; Q0K278; -.
DR STRING; 381666.H16_B1105; -.
DR GeneID; 57647008; -.
DR KEGG; reh:H16_B1105; -.
DR eggNOG; COG0624; Bacteria.
DR HOGENOM; CLU_021802_7_2_4; -.
DR OrthoDB; 9776600at2; -.
DR Proteomes; UP000008210; Chromosome 2.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd03885; M20_CPDG2; 1.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR InterPro; IPR017150; Pept_M20_glutamate_carboxypep.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR PANTHER; PTHR43808; ACETYLORNITHINE DEACETYLASE; 1.
DR PANTHER; PTHR43808:SF10; BLL3749 PROTEIN; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR PIRSF; PIRSF037238; Carboxypeptidase_G2; 1.
DR SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
DR PROSITE; PS00759; ARGE_DAPE_CPG2_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CAJ95896.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..419
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004174580"
FT DOMAIN 215..311
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
FT ACT_SITE 113
FT /evidence="ECO:0000256|PIRSR:PIRSR037238-1"
FT ACT_SITE 174
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR037238-1"
SQ SEQUENCE 419 AA; 43891 MW; 70B4B25A74D85459 CRC64;
MPFSVRHVAV AAALTLAGAG TLASAAQPDA ALLSAAQSAQ PALVQSLKEM VSIESGSANA
KGLAQMAGYT EKRLQALGAK VERMPVTKGP GTMVKATFTG TGKRRIMLIA HMDTVYPDNT
LATQPIREEG NRLYGPGIAD DKGGIAVILH SLEILKNQGW RDYAQITVLF NPDEEVGSVG
SGEAIAALAA QHDVVLSCEP TAAKDVVKAE SLLLGASGTA TATMQVKGRA SHAGAAPERG
RNALLELAHQ LQQTRDTASL VPGSQLNWTQ AQAGTVRNQI PESAVAYGDV RTTAAGAAEK
LKVALQDKVK SGQLVPETQT TVTMEEGRPP FVADARGRAL AKRAQEIYAE LDGRTLALAE
GTGGATDASY AARSGKPAVV ESFGLAGFGY HARDEYIELD SIVPRLYLMT RILQDIGRN
//
