ID   Q0K2G7_CUPNH            Unreviewed;       346 AA.
AC   Q0K2G7;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Isocitrate dehydrogenase [NAD] {ECO:0000313|EMBL:CAJ95807.1};
DE            EC=1.1.1.41 {ECO:0000313|EMBL:CAJ95807.1};
GN   Name=icd3 {ECO:0000313|EMBL:CAJ95807.1};
GN   OrderedLocusNames=H16_B1016 {ECO:0000313|EMBL:CAJ95807.1};
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ95807.1, ECO:0000313|Proteomes:UP000008210};
RN   [1] {ECO:0000313|EMBL:CAJ95807.1, ECO:0000313|Proteomes:UP000008210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC   337 {ECO:0000313|Proteomes:UP000008210};
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; AM260480; CAJ95807.1; -; Genomic_DNA.
DR   RefSeq; WP_010809741.1; NZ_CP039288.1.
DR   AlphaFoldDB; Q0K2G7; -.
DR   STRING; 381666.H16_B1016; -.
DR   GeneID; 57646914; -.
DR   KEGG; reh:H16_B1016; -.
DR   eggNOG; COG0473; Bacteria.
DR   HOGENOM; CLU_031953_0_1_4; -.
DR   OrthoDB; 5289857at2; -.
DR   Proteomes; UP000008210; Chromosome 2.
DR   GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:CAJ95807.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008210}.
FT   DOMAIN          8..338
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   346 AA;  36896 MW;  0A3028BCB60811A6 CRC64;
     MENGAREQIP ATLIPGDGIG PEVVDATVRV LEALGAPFAW DIRRAGMAGV EYSGDPLPQD
     TLDSIGRTGL ALKGPLTTPV GGGFRSVNVR LREAFNLYAN VRPARTLVPG RFENIDLVLV
     RENVGGFYVA HDYYIPVGDD PHAVAVSTGT NTRDACRRIA RFAFEYAVRN GRKKITVVHK
     ANILKALTGI FLEAAREVAR DYAGRVDMDD IIVDACAMQL VLNPWRFDML LCTNLFGDIL
     SDQIAGLVGG LGMAPGANIG DQAAIFEAVH GSAPDIAGKG IANPISLMLA AGLMLDHVGR
     QDLATRLRTA IELTLVQDQV KTGDLHGTAT TLQFADAVVK RIASAS
//