ID   Q0KCL6_CUPNH            Unreviewed;       483 AA.
AC   Q0KCL6;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=NAD-dependent aldehyde dehydrogenase {ECO:0000313|EMBL:CAJ92255.1};
DE            EC=1.2.1.3 {ECO:0000313|EMBL:CAJ92255.1};
GN   OrderedLocusNames=H16_A1114 {ECO:0000313|EMBL:CAJ92255.1};
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ92255.1, ECO:0000313|Proteomes:UP000008210};
RN   [1] {ECO:0000313|EMBL:CAJ92255.1, ECO:0000313|Proteomes:UP000008210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC   337 {ECO:0000313|Proteomes:UP000008210};
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AM260479; CAJ92255.1; -; Genomic_DNA.
DR   RefSeq; WP_011614886.1; NC_008313.1.
DR   AlphaFoldDB; Q0KCL6; -.
DR   STRING; 381666.H16_A1114; -.
DR   KEGG; reh:H16_A1114; -.
DR   PATRIC; fig|381666.6.peg.1500; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_4; -.
DR   OrthoDB; 6187633at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07105; ALDH_SaliADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42986; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   PANTHER; PTHR42986:SF1; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008210}.
FT   DOMAIN          17..472
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        251
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   483 AA;  49454 MW;  A5EDB47CC1F2F864 CRC64;
     MQSITMLING ERTQAANGAT FERRNPLDHS VATRAPAATA ADALAAADAA ARAFPAWRDT
     GPGERRALLM RAAQALEGKA GALTAAMAAE TGASAMWAGF NVQLAVGMLQ EAAALTTQIN
     GEVIPSDVPG SLAMAVRQGA GVVLGIAPWN APVILGVRAV ATALACGNTV ILKGSEICPA
     THGLIVDALA EAGFPAGVVN FVTNAPADAA AVVETIIAHP AVRRINFTGS TRVGRLIAQA
     CARHLKPAVL ELGGKAPLVV LDDADLDAAV DGAIFGAFAN SGQICMSTER IVVDASIADA
     FVARFAARAG ALPLADPRTG PAVLGSVVDM STVERCNAMI DDALAKGARL VCGGKAADTL
     MRATVLDYVT PDMEIYREES FGPVKAVVRV DGVEAAIACA NDSAYGLSAA VFGGDVARAM
     RVAGRIESGI CHVNGPTVHD EAQMPFGGVK ASGYGRFGGK AGIDAFTELR WITVQTTPRQ
     YPF
//