ID Q0KDX2_CUPNH Unreviewed; 904 AA.
AC Q0KDX2;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=ATP-dependent protease Clp, ATPase subunit {ECO:0000313|EMBL:CAJ91799.1};
GN Name=clpC1 {ECO:0000313|EMBL:CAJ91799.1};
GN OrderedLocusNames=H16_A0651 {ECO:0000313|EMBL:CAJ91799.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ91799.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ91799.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC involved in the recovery of the cell from heat-induced damage, in
CC cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the
CC processing of protein aggregates. Protein binding stimulates the ATPase
CC activity; ATP hydrolysis unfolds the denatured protein aggregates,
CC which probably helps expose new hydrophobic binding sites on the
CC surface of ClpB-bound aggregates, contributing to the solubilization
CC and refolding of denatured protein aggregates by DnaK.
CC {ECO:0000256|ARBA:ARBA00025613}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675}.
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DR EMBL; AM260479; CAJ91799.1; -; Genomic_DNA.
DR RefSeq; WP_011614630.1; NZ_CP039287.1.
DR AlphaFoldDB; Q0KDX2; -.
DR STRING; 381666.H16_A0651; -.
DR GeneID; 57642747; -.
DR KEGG; reh:H16_A0651; -.
DR PATRIC; fig|381666.6.peg.1020; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_1_0_4; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000008210; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR017729; ATPase_T6SS_ClpV1.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03345; VI_ClpV1; 1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF184; ATPASE WITH CHAPERONE ACTIVITY-RELATED; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000313|EMBL:CAJ91799.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:CAJ91799.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 9..155
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT REGION 163..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 97454 MW; BC06810B5B9B2C13 CRC64;
MDISRQALFG RLNLTLFKAI ESATAFCKLR GNPYVELVHW LHQLLQAPDG DLQRMLRHAG
ADLSVLEADL TRALAALPAG ATSISDFSFQ LESAIERAWV YATLAFSDDH VRGAYLLAAL
LKTPELRRTV LGISSQFAKV RPDDLVEMAP ALIAQSPESR EAAYDGSGLA PATPGEASGA
TAPASAGKPA LGRYCRDLTE EARAGRLDPV IGREHEIRTM TDILLRRRQN NPLLTGEAGV
GKTAVIEGLA QAIAAGEVPP SLKDIRLLSL DVGALLAGAS MKGEFEARLK GVLEEAAKSP
TPVILFVDEV HTLVGAGGQA GTGDAANLLK PALARGTLRT IGATTWSEYK RHIEKDPALT
RRFQVLQVME PDEARAVAMV RGLVRTFEAH HQVLIRDEGV RAAVRLSHRF IPSRQLPDKA
ISLLDTACAR VALSLHAPPA EVEHLRHELA AADAECALLA REAGFGRPDA ARIALARARR
EQFEADLALA SARWDRVRGL ATDLVARRYA LVQSASDEST VAAPARRTLD ELEGHLHAAQ
ADAPLVYTEV DERVVAAIVA DWTGIPVGRM VADEVATVMQ LPQTLGERVI GQGHALTQLG
ERVTTARAQL TDPNKPVGVF LLAGPSGVGK TETALALADA LYGGEQNLIT INLSEFQEPH
TVSTLKGAPP GYVGYGEGGV LTEAVRRRPY SVVLLDEVEK AHADIHEVFY QVFDKGYMED
GEGRHIDFRN TILLLTSNAG SDLLANLCED PALMPEPAAL RDALMPELRK VFPAAFLGRL
VVVPYLPLAA ENLGRIVRLH LDRVAVRMQH QHGIVLTYDD PVVEFIVARC PVGETGARQL
IGFIEQVIQP QLARLWLLAL SEKRELAVIA IRVADSAPAG LAYHTEYRVG HDAVVPECPE
AGSA
//
