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Database: UniProt
Entry: Q0MRD7_ACIBA
LinkDB: Q0MRD7_ACIBA
Original site: Q0MRD7_ACIBA 
ID   Q0MRD7_ACIBA            Unreviewed;       263 AA.
AC   Q0MRD7;
DT   19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   19-SEP-2006, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN   Name=aadA2 {ECO:0000313|EMBL:ABI14024.1};
GN   Synonyms=aadA1 {ECO:0000313|EMBL:AKA33620.1};
GN   ORFNames=ABUW_4057 {ECO:0000313|EMBL:AKA33620.1};
OS   Acinetobacter baumannii.
OG   Plasmid p1AB5075 {ECO:0000313|EMBL:AKA33620.1,
OG   ECO:0000313|Proteomes:UP000032746}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470 {ECO:0000313|EMBL:ABI14024.1};
RN   [1] {ECO:0000313|EMBL:ABI14024.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CS-b04 {ECO:0000313|EMBL:ABI14024.1};
RA   Tong W., Wang R., Chai D., Fang Y., Qian J., Li C., Guan X., Dong T.;
RT   "The pse-1 type beta-lactamases resistance gene is first identified in
RT   clinical isolates of multiple-drug resistance Acinetobacter baumannii from
RT   China.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEC47416.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NF813030 {ECO:0000313|EMBL:AEC47416.1};
RA   Wu K., Wang F., Sun J., Rui Y.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AHV83605.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=82 {ECO:0000313|EMBL:AHV83605.1};
RA   Solomennyi A., Evrogen J.S.C., Goncharov A.;
RT   "GES-12 complex integron.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AKA33620.1, ECO:0000313|Proteomes:UP000032746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB5075-UW {ECO:0000313|EMBL:AKA33620.1,
RC   ECO:0000313|Proteomes:UP000032746};
RC   PLASMID=p1AB5075 {ECO:0000313|EMBL:AKA33620.1,
RC   ECO:0000313|Proteomes:UP000032746};
RX   PubMed=25845845;
RA   Gallagher L.A., Ramage E., Weiss E.J., Radey M., Hayden H.S., Held K.G.,
RA   Huse H.K., Zurawski D.V., Brittnacher M.J., Manoil C.;
RT   "Resources for Genetic and Genomic Analysis of Emerging Pathogen
RT   Acinetobacter baumannii.";
RL   J. Bacteriol. 197:2027-2035(2015).
RN   [5] {ECO:0000313|Proteomes:UP000032746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB5075-UW {ECO:0000313|Proteomes:UP000032746};
RC   PLASMID=p1AB5075 {ECO:0000313|Proteomes:UP000032746};
RA   Gallagher L.A., Hayden H.S., Weiss E.J., Hager K.R., Ramage E., Radey M.R.,
RA   Bydalek R., Manoil C., Miller S.I., Brittnacher M.J.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAT68979.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IR2 {ECO:0000313|EMBL:BAT68979.1};
RA   Goudarzi M., Seyedjavadi S.S.;
RT   "Molecular characterization of integron-bearing Acinetobacter baumannii
RT   strains isolated from intensive care unit in Tehran-Iran.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AIZ49230.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=D4 {ECO:0000313|EMBL:AIZ49230.1};
RA   Hamidian M., Hall R.M.;
RT   "Acinetobacter baumannii genomic island 1 (AGI1) a novel antibiotic
RT   resistance island found in ST25 A. baumannii.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672,
CC         ECO:0000256|PIRNR:PIRNR000819};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070,
CC         ECO:0000256|PIRNR:PIRNR000819};
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DR   EMBL; DQ857723; ABI14024.1; -; Genomic_DNA.
DR   EMBL; HQ880257; AEC47416.1; -; Genomic_DNA.
DR   EMBL; KJ131499; AHV83605.1; -; Genomic_DNA.
DR   EMBL; KP054476; AIZ49230.1; -; Genomic_DNA.
DR   EMBL; CP008707; AKA33620.1; -; Genomic_DNA.
DR   EMBL; LC099465; BAT68979.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0MRD7; -.
DR   PATRIC; fig|470.1345.peg.3877; -.
DR   Proteomes; UP000032746; Plasmid p1AB5075.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW   ECO:0000256|PIRNR:PIRNR000819};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW   ECO:0000313|EMBL:AEC47416.1}; Plasmid {ECO:0000313|EMBL:AKA33620.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ABI14024.1}.
FT   DOMAIN          28..97
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          153..254
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   263 AA;  29549 MW;  D7FB27184F7D6B26 CRC64;
     MRVAVTIEIS NQLSEVLSVI ERHLESTLLA VHLYGSAVDG GLKPYSDIDL LVTVAVKLDE
     TTRRALLNDL MEASAFPGES ETLRAIEVTL VVHDDIIPWR YPAKRELQFG EWQRNDILAG
     IFEPAMIDID LAILLTKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
     GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
     SRADHLEEFI RFVKGEIIKS VGK
//
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