ID Q0MRD7_ACIBA Unreviewed; 263 AA.
AC Q0MRD7;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA2 {ECO:0000313|EMBL:ABI14024.1};
GN Synonyms=aadA1 {ECO:0000313|EMBL:AKA33620.1};
GN ORFNames=ABUW_4057 {ECO:0000313|EMBL:AKA33620.1};
OS Acinetobacter baumannii.
OG Plasmid p1AB5075 {ECO:0000313|EMBL:AKA33620.1,
OG ECO:0000313|Proteomes:UP000032746}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=470 {ECO:0000313|EMBL:ABI14024.1};
RN [1] {ECO:0000313|EMBL:ABI14024.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CS-b04 {ECO:0000313|EMBL:ABI14024.1};
RA Tong W., Wang R., Chai D., Fang Y., Qian J., Li C., Guan X., Dong T.;
RT "The pse-1 type beta-lactamases resistance gene is first identified in
RT clinical isolates of multiple-drug resistance Acinetobacter baumannii from
RT China.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEC47416.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NF813030 {ECO:0000313|EMBL:AEC47416.1};
RA Wu K., Wang F., Sun J., Rui Y.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AHV83605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=82 {ECO:0000313|EMBL:AHV83605.1};
RA Solomennyi A., Evrogen J.S.C., Goncharov A.;
RT "GES-12 complex integron.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AKA33620.1, ECO:0000313|Proteomes:UP000032746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB5075-UW {ECO:0000313|EMBL:AKA33620.1,
RC ECO:0000313|Proteomes:UP000032746};
RC PLASMID=p1AB5075 {ECO:0000313|EMBL:AKA33620.1,
RC ECO:0000313|Proteomes:UP000032746};
RX PubMed=25845845;
RA Gallagher L.A., Ramage E., Weiss E.J., Radey M., Hayden H.S., Held K.G.,
RA Huse H.K., Zurawski D.V., Brittnacher M.J., Manoil C.;
RT "Resources for Genetic and Genomic Analysis of Emerging Pathogen
RT Acinetobacter baumannii.";
RL J. Bacteriol. 197:2027-2035(2015).
RN [5] {ECO:0000313|Proteomes:UP000032746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AB5075-UW {ECO:0000313|Proteomes:UP000032746};
RC PLASMID=p1AB5075 {ECO:0000313|Proteomes:UP000032746};
RA Gallagher L.A., Hayden H.S., Weiss E.J., Hager K.R., Ramage E., Radey M.R.,
RA Bydalek R., Manoil C., Miller S.I., Brittnacher M.J.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:BAT68979.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IR2 {ECO:0000313|EMBL:BAT68979.1};
RA Goudarzi M., Seyedjavadi S.S.;
RT "Molecular characterization of integron-bearing Acinetobacter baumannii
RT strains isolated from intensive care unit in Tehran-Iran.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AIZ49230.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D4 {ECO:0000313|EMBL:AIZ49230.1};
RA Hamidian M., Hall R.M.;
RT "Acinetobacter baumannii genomic island 1 (AGI1) a novel antibiotic
RT resistance island found in ST25 A. baumannii.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; DQ857723; ABI14024.1; -; Genomic_DNA.
DR EMBL; HQ880257; AEC47416.1; -; Genomic_DNA.
DR EMBL; KJ131499; AHV83605.1; -; Genomic_DNA.
DR EMBL; KP054476; AIZ49230.1; -; Genomic_DNA.
DR EMBL; CP008707; AKA33620.1; -; Genomic_DNA.
DR EMBL; LC099465; BAT68979.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0MRD7; -.
DR PATRIC; fig|470.1345.peg.3877; -.
DR Proteomes; UP000032746; Plasmid p1AB5075.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:AEC47416.1}; Plasmid {ECO:0000313|EMBL:AKA33620.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ABI14024.1}.
FT DOMAIN 28..97
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 153..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29549 MW; D7FB27184F7D6B26 CRC64;
MRVAVTIEIS NQLSEVLSVI ERHLESTLLA VHLYGSAVDG GLKPYSDIDL LVTVAVKLDE
TTRRALLNDL MEASAFPGES ETLRAIEVTL VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPAMIDID LAILLTKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
SRADHLEEFI RFVKGEIIKS VGK
//