ID   Q0N541_VARV             Unreviewed;       224 AA.
AC   Q0N541; A0A1U8QTT4; Q0NCL6; Q0NLU8; Q76PZ8;
DT   19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   19-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Viral late gene transcription factor 3 {ECO:0000256|ARBA:ARBA00021729};
DE   AltName: Full=Trans-activator protein A2 {ECO:0000256|ARBA:ARBA00029581};
GN   Name=A2L {ECO:0000313|EMBL:CAB54705.1};
GN   ORFNames=VARV_AFG70_vlt4_109 {ECO:0000313|EMBL:ABG43274.1},
GN   VARV_BEN68_59_109 {ECO:0000313|EMBL:ABF22868.1}, VARV_BOT72_143_109
GN   {ECO:0000313|EMBL:ABF23072.1}, VARV_BOT73_225_109
GN   {ECO:0000313|EMBL:ABF23274.1}, VARV_BRZ66_39_109
GN   {ECO:0000313|EMBL:ABF23478.1}, VARV_BSH74_nur_109
GN   {ECO:0000313|EMBL:ABF23681.1}, VARV_BSH74_shz_109
GN   {ECO:0000313|EMBL:ABF23878.1}, VARV_BSH74_sol_109
GN   {ECO:0000313|EMBL:ABF24075.1}, VARV_BSH75_banu_109
GN   {ECO:0000313|EMBL:ABG43477.1}, VARV_CHN48_horn_109
GN   {ECO:0000313|EMBL:ABG43678.1}, VARV_CNG70_227_109
GN   {ECO:0000313|EMBL:ABF24272.1}, VARV_CNG70_46_109
GN   {ECO:0000313|EMBL:ABG43882.1}, VARV_ETH72_16_109
GN   {ECO:0000313|EMBL:ABF24473.1}, VARV_ETH72_17_109
GN   {ECO:0000313|EMBL:ABF24675.1}, VARV_GER58_hdlg_109
GN   {ECO:0000313|EMBL:ABG44084.1}, VARV_GUI69_005_109
GN   {ECO:0000313|EMBL:ABF24876.1}, VARV_IND53_mad_109
GN   {ECO:0000313|EMBL:ABF25078.1}, VARV_IND53_ndel_109
GN   {ECO:0000313|EMBL:ABF25278.1}, VARV_IND64_vel4_109
GN   {ECO:0000313|EMBL:ABG44287.1}, VARV_IND64_vel5_109
GN   {ECO:0000313|EMBL:ABG44491.1}, VARV_IRN72_tbrz_109
GN   {ECO:0000313|EMBL:ABG44693.1}, VARV_JAP51_hrpr_109
GN   {ECO:0000313|EMBL:ABF25682.1}, VARV_JAP51_stwl_109
GN   {ECO:0000313|EMBL:ABF25883.1}, VARV_KOR47_lee_109
GN   {ECO:0000313|EMBL:ABF26085.1}, VARV_KUW67_1629_109
GN   {ECO:0000313|EMBL:ABF26287.1}, VARV_NEP73_175_109
GN   {ECO:0000313|EMBL:ABG44896.1}, VARV_NIG69_001_109
GN   {ECO:0000313|EMBL:ABF26488.1}, VARV_PAK69_lah_109
GN   {ECO:0000313|EMBL:ABG45098.1}, VARV_SAF65_102_109
GN   {ECO:0000313|EMBL:ABF26691.1}, VARV_SAF65_103_109
GN   {ECO:0000313|EMBL:ABF26891.1}, VARV_SLN68_258_109
GN   {ECO:0000313|EMBL:ABF27094.1}, VARV_SOM77_1252_109
GN   {ECO:0000313|EMBL:ABF27296.1}, VARV_SOM77_1605_109
GN   {ECO:0000313|EMBL:ABF27495.1}, VARV_SOM77_ali_109
GN   {ECO:0000313|EMBL:ABG45301.1}, VARV_SUD47_jub_109
GN   {ECO:0000313|EMBL:ABF27694.1}, VARV_SUD47_rum_109
GN   {ECO:0000313|EMBL:ABF27894.1}, VARV_SUM70_222_109
GN   {ECO:0000313|EMBL:ABG45503.1}, VARV_SUM70_228_109
GN   {ECO:0000313|EMBL:ABF28094.1}, VARV_SYR72_119_109
GN   {ECO:0000313|EMBL:ABG45705.1}, VARV_TAN65_kem_109
GN   {ECO:0000313|EMBL:ABF28292.1}, VARV_UNK44_harv_109
GN   {ECO:0000313|EMBL:ABF28491.1}, VARV_UNK46_hind_109
GN   {ECO:0000313|EMBL:ABF28692.1}, VARV_UNK47_hig_109
GN   {ECO:0000313|EMBL:ABF28891.1}, VARV_UNK52_but_109
GN   {ECO:0000313|EMBL:ABF29094.1}, VARV_YUG72_164_109
GN   {ECO:0000313|EMBL:ABF29298.1};
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255 {ECO:0000313|EMBL:ABF29298.1, ECO:0000313|Proteomes:UP000116035};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:CAB54705.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Garcia-1966 {ECO:0000313|EMBL:CAB54705.1};
RA   Shchelkunov S.N., Totmenin A.V., Gutorov V.V., Safronov P.F., Massung R.F.,
RA   Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M., Esposito J.J.,
RA   Sosnovtsev S.;
RT   "Analysis of the complete coding sequence of DNA of alastrim variola minor
RT   virus strain Garcia-1966.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001814, ECO:0000313|Proteomes:UP000008171}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Afghanistan 1970 Variolator 4 {ECO:0000313|EMBL:ABG43274.1},
RC   Bangladesh 1974 {ECO:0000313|EMBL:ABF23681.1}, Bangladesh 1975 v75-550
RC   Banu {ECO:0000313|EMBL:ABG43477.1}, Benin
RC   {ECO:0000313|EMBL:ABF22868.1}, Botswana 1972
RC   {ECO:0000313|EMBL:ABF23072.1}, Botswana 1973
RC   {ECO:0000313|EMBL:ABF23274.1}, Brazil 1966
RC   {ECO:0000313|EMBL:ABF23478.1}, China Horn 1948
RC   {ECO:0000313|EMBL:ABG43678.1}, Congo 1970 v70-46 Kinshasa
RC   {ECO:0000313|EMBL:ABG43882.1}, Congo 9 1970
RC   {ECO:0000313|EMBL:ABF24272.1}, Ethiopia 1972
RC   {ECO:0000313|EMBL:ABF24473.1}, Germany 1958 Heidelberg
RC   {ECO:0000313|EMBL:ABG44084.1}, Guinea 1969
RC   {ECO:0000313|EMBL:ABF24876.1}, India 1953
RC   {ECO:0000313|EMBL:ABF25078.1}, India 1964 7124 Vellore
RC   {ECO:0000313|EMBL:ABG44287.1}, India 1964 7125 Vellore
RC   {ECO:0000313|EMBL:ABG44491.1}, Iran 1972 2602 Tabriz
RC   {ECO:0000313|EMBL:ABG44693.1}, Japan 1951
RC   {ECO:0000313|EMBL:ABF25682.1}, Korea 1947
RC   {ECO:0000313|EMBL:ABF26085.1}, Kuwait 1967
RC   {ECO:0000313|EMBL:ABF26287.1}, Nepal 1973 V73-175
RC   {ECO:0000313|EMBL:ABG44896.1}, Niger 1969
RC   {ECO:0000313|EMBL:ABF26488.1}, Pakistan 1969
RC   {ECO:0000313|EMBL:ABG45098.1}, Sierra Leone 1969
RC   {ECO:0000313|EMBL:ABF27094.1}, Somalia 1977
RC   {ECO:0000313|EMBL:ABF27296.1}, South Africa 1965
RC   {ECO:0000313|EMBL:ABF26691.1}, Sudan 1947
RC   {ECO:0000313|EMBL:ABF27694.1}, Sumatra 1970 V70-222
RC   {ECO:0000313|EMBL:ABG45503.1}, Sumatra 1970 V70-228
RC   {ECO:0000313|EMBL:ABF28094.1}, Syria 1972 V72-199
RC   {ECO:0000313|EMBL:ABG45705.1}, Tanzania 1965 kembula
RC   {ECO:0000313|EMBL:ABF28292.1}, United Kingdom 1946 Harvey
RC   {ECO:0000313|EMBL:ABF28491.1}, United Kingdom 1946 Hinden
RC   {ECO:0000313|EMBL:ABF28692.1}, United Kingdom 1947 Higgins
RC   {ECO:0000313|EMBL:ABF28891.1}, United Kingdom 1952 Butler
RC   {ECO:0000313|EMBL:ABF29094.1}, Variola virus (isolate
RC   Human/Brazil/v66-39/1966) {ECO:0000313|Proteomes:UP000001814}, Variola
RC   virus (isolate Human/South Africa/102/1965)
RC   {ECO:0000313|Proteomes:UP000008171}, and Yugoslavia 1972 V72-164
RC   {ECO:0000313|EMBL:ABF29298.1};
RX   PubMed=16873609; DOI=10.1126/science.1125134;
RA   Esposito J.J., Sammons S.A., Frace A.M., Osborne J.D., Olsen-Rasmussen M.,
RA   Zhang M., Govil D., Damon I.K., Kline R., Laker M., Li Y., Smith G.L.,
RA   Meyer H., LeDuc J.W., Wohlhueter R.M.;
RT   "Genome sequence diversity and clues to the evolution of variola (smallpox)
RT   virus.";
RL   Science 313:807-812(2006).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters. {ECO:0000256|ARBA:ARBA00003347}.
CC   -!- SUBUNIT: Interacts with the late transcription elongation factor VLTF-
CC       4/OPG110. Interacts with the late transcription factors VLTF-1/OPG093.
CC       {ECO:0000256|ARBA:ARBA00034800}.
CC   -!- SIMILARITY: Belongs to the orthopoxvirus VLTF-3/OPG127 family.
CC       {ECO:0000256|ARBA:ARBA00034715}.
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DR   EMBL; DQ441416; ABF22868.1; -; Genomic_DNA.
DR   EMBL; DQ441417; ABF23072.1; -; Genomic_DNA.
DR   EMBL; DQ441418; ABF23274.1; -; Genomic_DNA.
DR   EMBL; DQ441419; ABF23478.1; -; Genomic_DNA.
DR   EMBL; DQ441420; ABF23681.1; -; Genomic_DNA.
DR   EMBL; DQ441421; ABF23878.1; -; Genomic_DNA.
DR   EMBL; DQ441422; ABF24075.1; -; Genomic_DNA.
DR   EMBL; DQ441423; ABF24272.1; -; Genomic_DNA.
DR   EMBL; DQ441424; ABF24473.1; -; Genomic_DNA.
DR   EMBL; DQ441425; ABF24675.1; -; Genomic_DNA.
DR   EMBL; DQ441426; ABF24876.1; -; Genomic_DNA.
DR   EMBL; DQ441427; ABF25078.1; -; Genomic_DNA.
DR   EMBL; DQ441428; ABF25278.1; -; Genomic_DNA.
DR   EMBL; DQ441430; ABF25682.1; -; Genomic_DNA.
DR   EMBL; DQ441431; ABF25883.1; -; Genomic_DNA.
DR   EMBL; DQ441432; ABF26085.1; -; Genomic_DNA.
DR   EMBL; DQ441433; ABF26287.1; -; Genomic_DNA.
DR   EMBL; DQ441434; ABF26488.1; -; Genomic_DNA.
DR   EMBL; DQ441435; ABF26691.1; -; Genomic_DNA.
DR   EMBL; DQ441436; ABF26891.1; -; Genomic_DNA.
DR   EMBL; DQ441437; ABF27094.1; -; Genomic_DNA.
DR   EMBL; DQ441438; ABF27296.1; -; Genomic_DNA.
DR   EMBL; DQ441439; ABF27495.1; -; Genomic_DNA.
DR   EMBL; DQ441440; ABF27694.1; -; Genomic_DNA.
DR   EMBL; DQ441441; ABF27894.1; -; Genomic_DNA.
DR   EMBL; DQ441442; ABF28094.1; -; Genomic_DNA.
DR   EMBL; DQ441443; ABF28292.1; -; Genomic_DNA.
DR   EMBL; DQ441444; ABF28491.1; -; Genomic_DNA.
DR   EMBL; DQ441445; ABF28692.1; -; Genomic_DNA.
DR   EMBL; DQ441446; ABF28891.1; -; Genomic_DNA.
DR   EMBL; DQ441447; ABF29094.1; -; Genomic_DNA.
DR   EMBL; DQ441448; ABF29298.1; -; Genomic_DNA.
DR   EMBL; DQ437580; ABG43274.1; -; Genomic_DNA.
DR   EMBL; DQ437581; ABG43477.1; -; Genomic_DNA.
DR   EMBL; DQ437582; ABG43678.1; -; Genomic_DNA.
DR   EMBL; DQ437583; ABG43882.1; -; Genomic_DNA.
DR   EMBL; DQ437584; ABG44084.1; -; Genomic_DNA.
DR   EMBL; DQ437585; ABG44287.1; -; Genomic_DNA.
DR   EMBL; DQ437586; ABG44491.1; -; Genomic_DNA.
DR   EMBL; DQ437587; ABG44693.1; -; Genomic_DNA.
DR   EMBL; DQ437588; ABG44896.1; -; Genomic_DNA.
DR   EMBL; DQ437589; ABG45098.1; -; Genomic_DNA.
DR   EMBL; DQ437590; ABG45301.1; -; Genomic_DNA.
DR   EMBL; DQ437591; ABG45503.1; -; Genomic_DNA.
DR   EMBL; DQ437592; ABG45705.1; -; Genomic_DNA.
DR   EMBL; Y16780; CAB54705.1; -; Genomic_DNA.
DR   RefSeq; NP_042149.1; NC_001611.1.
DR   SMR; Q0N541; -.
DR   GeneID; 1486506; -.
DR   KEGG; vg:1486506; -.
DR   Proteomes; UP000001814; Genome.
DR   Proteomes; UP000008171; Genome.
DR   Proteomes; UP000098225; Genome.
DR   Proteomes; UP000098436; Genome.
DR   Proteomes; UP000100387; Genome.
DR   Proteomes; UP000105724; Genome.
DR   Proteomes; UP000107112; Genome.
DR   Proteomes; UP000111493; Segment.
DR   Proteomes; UP000112452; Genome.
DR   Proteomes; UP000112873; Genome.
DR   Proteomes; UP000113219; Genome.
DR   Proteomes; UP000116035; Genome.
DR   Proteomes; UP000117241; Genome.
DR   Proteomes; UP000117332; Genome.
DR   Proteomes; UP000118036; Genome.
DR   Proteomes; UP000120193; Genome.
DR   Proteomes; UP000122860; Genome.
DR   Proteomes; UP000126850; Genome.
DR   Proteomes; UP000127036; Genome.
DR   Proteomes; UP000127760; Genome.
DR   Proteomes; UP000129347; Genome.
DR   Proteomes; UP000130170; Genome.
DR   Proteomes; UP000133301; Genome.
DR   Proteomes; UP000134328; Genome.
DR   Proteomes; UP000134690; Genome.
DR   Proteomes; UP000136147; Genome.
DR   Proteomes; UP000136898; Genome.
DR   Proteomes; UP000140295; Genome.
DR   Proteomes; UP000141018; Genome.
DR   Proteomes; UP000142290; Genome.
DR   Proteomes; UP000143307; Genome.
DR   Proteomes; UP000144412; Genome.
DR   Proteomes; UP000145752; Genome.
DR   Proteomes; UP000153789; Genome.
DR   Proteomes; UP000154290; Genome.
DR   Proteomes; UP000156539; Genome.
DR   Proteomes; UP000158123; Genome.
DR   Proteomes; UP000158565; Genome.
DR   Proteomes; UP000160505; Genome.
DR   Proteomes; UP000165444; Genome.
DR   Proteomes; UP000166432; Genome.
DR   Proteomes; UP000168855; Genome.
DR   Proteomes; UP000170050; Genome.
DR   Proteomes; UP000170428; Genome.
DR   Proteomes; UP000181005; Genome.
DR   Proteomes; UP000181075; Genome.
DR   GO; GO:0046782; P:regulation of viral transcription; IEA:InterPro.
DR   InterPro; IPR007031; Poxvirus_VLTF3.
DR   InterPro; IPR014900; VLTF-3_Zn_ribbon.
DR   Pfam; PF08792; A2L_zn_ribbon; 1.
DR   Pfam; PF04947; Pox_VLTF3; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Transcription {ECO:0000256|ARBA:ARBA00023015};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          1..32
FT                   /note="Viral late gene transcription factor 3 zinc ribbon"
FT                   /evidence="ECO:0000259|Pfam:PF08792"
SQ   SEQUENCE   224 AA;  26289 MW;  B2406504F65885FB CRC64;
     MNLRLCSGCR HNGIVSEQGY EYCIFCESVF QKCTKVQKKS NFHVSNKLIH LRNVLRRLLS
     HQCSGEIISE LLDIMEKNQI STDDVDANFV SSFLKANERI NKKDYKLVFE IINQVKDEKL
     NLSTEKINEV VEIFKHLVFF CQENTPSKTI NYSFFLDKIF DITSVTKNLK PQTVKNYTKN
     NSNQLVWENF LAHMRSKKRV TMVEDYGHEY VFVDERFSTC SLEV
//