ID Q0NFU1_VAR46 Unreviewed; 349 AA.
AC Q0NFU1;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Crm-B secreted TNF-alpha-receptor-like protein {ECO:0000313|EMBL:ABF25572.1};
GN ORFNames=VARV_JAP46_yam_205 {ECO:0000313|EMBL:ABF25572.1};
OS Variola virus (isolate Human/Japan/Yamada MS-2(A)/1946) (VARV) (Smallpox
OS virus).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Variola virus.
OX NCBI_TaxID=587202 {ECO:0000313|EMBL:ABF25572.1, ECO:0000313|Proteomes:UP000006909};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABF25572.1, ECO:0000313|Proteomes:UP000006909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Variola virus (isolate Human/Japan/Yamada MS-2(A)/1946)
RC {ECO:0000313|Proteomes:UP000006909};
RX PubMed=16873609; DOI=10.1126/science.1125134;
RA Esposito J.J., Sammons S.A., Frace A.M., Osborne J.D., Olsen-Rasmussen M.,
RA Zhang M., Govil D., Damon I.K., Kline R., Laker M., Li Y., Smith G.L.,
RA Meyer H., LeDuc J.W., Wohlhueter R.M.;
RT "Genome sequence diversity and clues to the evolution of variola (smallpox)
RT virus.";
RL Science 313:807-812(2006).
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG002 family.
CC {ECO:0000256|ARBA:ARBA00034724}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; DQ441429; ABF25572.1; -; Genomic_DNA.
DR SMR; Q0NFU1; -.
DR Proteomes; UP000006909; Genome.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:InterPro.
DR CDD; cd15839; TNFRSF_viral; 1.
DR Gene3D; 2.60.240.20; -; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034059; TNFRSF_N_viral.
DR PANTHER; PTHR47386; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B; 1.
DR PANTHER; PTHR47386:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B; 1.
DR Pfam; PF07190; CrmD_SECRET; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PIRSF; PIRSF001790; TNF_C22L; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT REPEAT 31..65
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 31..65
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 67..108
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 67..108
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DISULFID 44..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 47..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 68..83
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 90..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 349 AA; 38189 MW; D45D40B5C6E780EF CRC64;
MKSVLYLYIL FLSCIIINGR DAAPYTPPNG KCKDTEYKRH NLCCLSCPPG TYASRLCDSK
TNTQCTPCGS GTFTSRNNHL PACLSCNGRC NSNQVETRSC NTTHNRICEC SPGYYCLLKG
SSGCKACVSQ TKCGIGYGVS GHTSVGDVIC SPCGFGTYSH TVSSADKCEP VPNNTFNYID
VEITLYPVND TSCTRTTTTG LSESILTSEL TITMNHTDCN PVFREEYFSV LNKVATSGFF
TGENRYQNIS KVCTLNFEIK CNNKGSSFKQ LTKAKNDDGM MSHSETVTLA GDCLSSVDIY
ILYSNTNAQD YETDTISYRV GNVLDDDSHM PGSCNIHKPI TNSKPTRFL
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