ID Q0P3Q7_XENLA Unreviewed; 260 AA.
AC Q0P3Q7;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Distal-less homeobox 6 L homeolog {ECO:0000313|RefSeq:NP_001085305.1};
DE SubName: Full=LOC443711 protein {ECO:0000313|EMBL:AAI22514.1};
GN Name=dlx6.L {ECO:0000313|RefSeq:NP_001085305.1,
GN ECO:0000313|Xenbase:XB-GENE-866468};
GN Synonyms=dlx-6 {ECO:0000313|RefSeq:NP_001085305.1}, dlx6
GN {ECO:0000313|RefSeq:NP_001085305.1,
GN ECO:0000313|Xenbase:XB-GENE-866468}, dlx6-a
GN {ECO:0000313|RefSeq:NP_001085305.1}, dlx6-b
GN {ECO:0000313|RefSeq:NP_001085305.1}, LOC443711
GN {ECO:0000313|EMBL:AAI22514.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI22514.1};
RN [1] {ECO:0000313|RefSeq:NP_001085305.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI22514.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI22514.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085305.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family.
CC {ECO:0000256|ARBA:ARBA00007916}.
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DR EMBL; BC122513; AAI22514.1; -; mRNA.
DR RefSeq; NP_001085305.1; NM_001091836.1.
DR STRING; 8355.Q0P3Q7; -.
DR PaxDb; 8355-Q0P3Q7; -.
DR DNASU; 443711; -.
DR GeneID; 443711; -.
DR KEGG; xla:443711; -.
DR AGR; Xenbase:XB-GENE-866468; -.
DR CTD; 443711; -.
DR Xenbase; XB-GENE-866468; dlx6.L.
DR OMA; PSYHNNA; -.
DR OrthoDB; 2969529at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 443711; Expressed in internal ear and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24327:SF26; HOMEOBOX PROTEIN DLX-6; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 132..192
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 134..193
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 44..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 29091 MW; D08794E4DEEA4FBE CRC64;
MMTMTTMADG LEAQDSSKSA FMEFGQQQSH SQQSSPVMAA GHYPLHCLHS GSHPHHHPHH
QHDTNYSGSN SYSRSLAAYP YMSHSQHSPY LQTYNSNSSS STTTQNRAEE PADQQKTTVI
ENGEIRFNGK GKKIRKPRTI YSSLQLQALN HRFQQTQYLA LPERAELAAS LGLTQTQVKI
WFQNKRSKYK KLLKQGSNPL ESDPLPGTAA LSPRSPAIPP VWDVSATAKG VSMAPNSYMP
GYSHWYSSPH QDTMQRSQMM
//
