ID Q0P4R0_XENTR Unreviewed; 1185 AA.
AC Q0P4R0; F6WNN1;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=Bromodomain-containing 1 {ECO:0000313|EMBL:AAI21943.1, ECO:0000313|Ensembl:ENSXETP00000031780};
DE SubName: Full=Bromodomain-containing protein 1 {ECO:0000313|RefSeq:NP_001073031.1};
GN Name=brd1 {ECO:0000313|Ensembl:ENSXETP00000031780,
GN ECO:0000313|RefSeq:NP_001073031.1,
GN ECO:0000313|Xenbase:XB-GENE-949377};
GN Synonyms=LOC733743 {ECO:0000313|EMBL:AAI21943.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI21943.1};
RN [1] {ECO:0000313|RefSeq:NP_001073031.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI21943.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI21943.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000031780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000031780};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000031780}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001073031.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BC121942; AAI21943.1; -; mRNA.
DR RefSeq; NP_001073031.1; NM_001079563.1.
DR RefSeq; XP_012814620.1; XM_012959166.2.
DR STRING; 8364.ENSXETP00000031174; -.
DR PaxDb; 8364-ENSXETP00000031780; -.
DR Ensembl; ENSXETT00000031780; ENSXETP00000031780; ENSXETG00000014519.
DR GeneID; 733743; -.
DR KEGG; xtr:733743; -.
DR AGR; Xenbase:XB-GENE-949377; -.
DR CTD; 23774; -.
DR Xenbase; XB-GENE-949377; brd1.
DR eggNOG; KOG0955; Eukaryota.
DR HOGENOM; CLU_003589_1_0_1; -.
DR OMA; GMWISTD; -.
DR OrthoDB; 163389at2759; -.
DR TreeFam; TF316118; -.
DR Reactome; R-XTR-3214847; HATs acetylate histones.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000014519; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05512; Bromo_brd1_like; 1.
DR CDD; cd15702; ePHD_BRPF2; 1.
DR CDD; cd15677; PHD_BRPF2; 1.
DR CDD; cd20157; PWWP_BRPF2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR042004; BRPF2_ePHD.
DR InterPro; IPR042009; BRPF2_PHD.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF17; BROMODOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF00855; PWWP; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 2.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 214..264
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 268..389
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 578..648
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1056..1139
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 514..557
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 135033 MW; 1BEC413A8EEF45DE CRC64;
MRRKGRWHRV SAPRSSTSPC SIKHSPTRET LTYAQAQRMV EIEIEGRLHR ISIFDPLEIV
SEDDLTAQEI NECNSNKENS EQPPQVCLRS KRHKASKEKK KSEVLPTAHG HTTTSVLPEP
KVRVIECSPP SAPNRSPSYY KFQDKSPEEL DKEVEYDMDE EDYAWLEIIN EKRKSEGFSA
VSQDIFEFLM DRFEKESYCE NQKQGDQQSL IDEDAVCCIC MDGECQNSNV ILFCDMCNLA
VHQECYGVPY IPEGQWLCRH CLQSRNIPID CVLCPNKGGA FKKTDDDRWG HVVCALWIPE
VGFANTVFIE PIDGVRNIPP ARWKLTCYLC KQKGVGACIQ CHKANCYTAF HVTCAQKAGL
YMKMEPVKEV AGSITTFSVK KTAYCDAHTP PGCVRRPLNI YEEPESKNGI CRKSSDKNIR
STSKARRKTT KAKKELNETC NVLPTITVPD IPPQRVNKII NQVSIPRKKQ FIERVHSYWM
LKRLSRNGIP LLRRLQSSLQ SQRNIQESED DEEVQALKKK LKYLQRLRHD LERARLLIEL
IRKREKLKRE QVKVEQVAME LKLTPLTVLL RSLLEQLQEK DPARIFAHPV NLTEVPDYLD
HIKHPMDFST MKKRLEDQRY RNLNEFEEDF NLIIENCMKY NAKDTIFYRA AVRLRDHGGV
LLRQARREAN VIGFDEETGM HLPEQPKIEA PPQFSWEDVD KLLNPNNRAH MALEEQLKEL
LEKLDLTFAM KSSGSRSKRL KLLKREIANV RQMLSQQHVQ PPQIESGIGS FEEDGSMLND
GEEEGDKSPP KLEPSDALPL PSNSETNSEP PTLKPIELNP EQSKLYKRVT FDNELHSTTI
QNEMINGHTP ENLLKDSNLN ESSDSEVAES STDVNRRTSI LFRKSKSVSP QKPSKNTETQ
PTSPQLGTKT FLSVVLPRLE TLLQPRKRSR STCGDSEVDG ESPVKRLDTG LSNGYGEGEK
EKEFNITPGR KLEPRRRCAS ESSISSNNSI LCNPSFGLPK CGKGKPALIR RHTIEDRSEL
ISCIENGNYA RAARIAAEVG QTNMWVAAST SAFLEPLKVV WAKCSGYPSY PALIIDPKMP
RVGCHHNGVA IPVPPMDVLK TGDQMQTRAE EKLFLVLFFD NKRSWQWLPK SKMVPLGVDE
TIDKLKMMEG RNSSIRKAVR VAYDRALNHL SRVQGESVSD FSDID
//
