ID DAW1_BOVIN Reviewed; 415 AA.
AC Q0P593;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Dynein assembly factor with WD repeat domains 1;
DE AltName: Full=Outer row dynein assembly protein 16 homolog;
DE AltName: Full=WD repeat-containing protein 69;
GN Name=DAW1; Synonyms=WDR69;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for axonemal dynein assembly and ciliary motility in
CC ciliated organs, including Kupffer's vesicle, during embryogenesis.
CC Facilitates the onset of robust cilia motility during development.
CC {ECO:0000250|UniProtKB:Q8N136}.
CC -!- SUBUNIT: Interacts with IFT46. {ECO:0000250|UniProtKB:Q8N136}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body
CC {ECO:0000250|UniProtKB:Q3Y8L7}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q3Y8L7}. Note=Expression is concentrated
CC at the flagellum basal body but is also detected along the length of
CC the flagellum. {ECO:0000250|UniProtKB:Q3Y8L7}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR69 family. {ECO:0000305}.
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DR EMBL; BC120334; AAI20335.1; -; mRNA.
DR RefSeq; NP_001069398.1; NM_001075930.1.
DR AlphaFoldDB; Q0P593; -.
DR SMR; Q0P593; -.
DR STRING; 9913.ENSBTAP00000028431; -.
DR PaxDb; 9913-ENSBTAP00000028431; -.
DR Ensembl; ENSBTAT00000028431.5; ENSBTAP00000028431.5; ENSBTAG00000021327.5.
DR GeneID; 530118; -.
DR KEGG; bta:530118; -.
DR CTD; 164781; -.
DR VEuPathDB; HostDB:ENSBTAG00000021327; -.
DR VGNC; VGNC:27883; DAW1.
DR eggNOG; KOG0272; Eukaryota.
DR GeneTree; ENSGT00940000167309; -.
DR InParanoid; Q0P593; -.
DR OMA; TGQCSQV; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000021327; Expressed in oviduct epithelium and 44 other cell types or tissues.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF637; WD REPEAT DOMAIN 5; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 8.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..415
FT /note="Dynein assembly factor with WD repeat domains 1"
FT /id="PRO_0000293711"
FT REPEAT 90..129
FT /note="WD 1"
FT REPEAT 132..174
FT /note="WD 2"
FT REPEAT 175..214
FT /note="WD 3"
FT REPEAT 217..256
FT /note="WD 4"
FT REPEAT 259..298
FT /note="WD 5"
FT REPEAT 301..340
FT /note="WD 6"
FT REPEAT 343..384
FT /note="WD 7"
FT REPEAT 386..415
FT /note="WD 8"
SQ SEQUENCE 415 AA; 45857 MW; 2BD372D048A11223 CRC64;
MKLKSLLLRY YPPGIMLEYE KSGQLKTKSI DLLDLDPSTD VSALVEEIQK AEPLITASRS
DQVKLLIQRL QNKLGQHSNH KFYLFKVLRA HILPLTNVAL NKSGSCFITG SYDRTCKLWD
TASGEELHTL EGHRNVVYAI AFNNPYGDKI ATGSFDKTCK LWSVETGKCY HTFRGHTAEI
VCLSFNPQST LVATGSMDTT AKLWDIQSGE EVFTLTGHSA EIISLSFNTS GNRIITGSFD
HTVTVWEADT GRKVYTLIGH CAEISSAVFN WDCSLILTGS MDKTCKLWDA VNGKCVATLT
GHDDEILDSC FDYTGKLIAT ASADGTARIF SAATRECVTK LEGHEGEISK ISFNPQGNRL
LTGSSDKTAR IWDAQTGQCL QVLEGHTDEI FSCAFNYKGD IIITGSKDNT CRIWR
//
