ID Q0P8P4_CAMJE Unreviewed; 1041 AA.
AC Q0P8P4;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Secreted serine protease {ECO:0000313|EMBL:CAL35477.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:CAL35477.1};
GN OrderedLocusNames=Cj1365c {ECO:0000313|EMBL:CAL35477.1};
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS 11168).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222 {ECO:0000313|EMBL:CAL35477.1, ECO:0000313|Proteomes:UP000000799};
RN [1] {ECO:0000313|EMBL:CAL35477.1, ECO:0000313|Proteomes:UP000000799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700819 / NCTC 11168 {ECO:0000313|Proteomes:UP000000799};
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K., Ketley J.M., Churcher C., Basham D.,
RA Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K.,
RA Karlyshev A., Moule S., Pallen M.J., Penn C.W., Quail M., Rajandream M.A.,
RA Rutherford K.M., VanVliet A., Whitehead S., Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL111168; CAL35477.1; -; Genomic_DNA.
DR PIR; B81281; B81281.
DR RefSeq; WP_002858452.1; NZ_SZUC01000003.1.
DR RefSeq; YP_002344753.1; NC_002163.1.
DR AlphaFoldDB; Q0P8P4; -.
DR IntAct; Q0P8P4; 1.
DR STRING; 192222.Cj1365c; -.
DR PaxDb; 192222-Cj1365c; -.
DR EnsemblBacteria; CAL35477; CAL35477; Cj1365c.
DR GeneID; 905658; -.
DR KEGG; cje:Cj1365c; -.
DR PATRIC; fig|192222.6.peg.1346; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG4625; Bacteria.
DR HOGENOM; CLU_288319_0_0_7; -.
DR OrthoDB; 9804931at2; -.
DR Proteomes; UP000000799; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04848; Peptidases_S8_Autotransporter_serine_protease_like; 1.
DR Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR013425; Autotrns_rpt.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR017318; Pept_S8A_subtilisin_campylobac.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034061; Peptidases_S8_Autotransporter.
DR NCBIfam; TIGR02601; autotrns_rpt; 1.
DR PANTHER; PTHR43399:SF5; CELL WALL-ASSOCIATED PROTEASE; 1.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR Pfam; PF03797; Autotransporter; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PIRSF; PIRSF037905; Subtilisin_rel_CJE1557; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF103515; Autotransporter; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000000799};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 775..1041
FT /note="Autotransporter"
FT /evidence="ECO:0000259|PROSITE:PS51208"
FT ACT_SITE 43
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 80
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 292
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1041 AA; 116304 MW; ED6C97620D911D67 CRC64;
MKKFFCLTLV CKLFALSEFE LHHIDKVHKL GYSGDTIIIG VADDAFNQDH ISLKDKILKS
TYPTDTAGKQ LIPDLKKSTH GSHVAGIAVG AKIGDSKPYG VAYGAKFYGA GVFPNGSYTQ
IPDIYNFFKD VSIINNSWGI NFYPYFNLKA SNSGLVDCTQ TNQGTSYNIC NTPLEYVMKA
DKVANDMMRL SKDKGVLNVF AAGNEGILSP ALHAILPSYD ESLRAWLAVG ALDANEITLE
SDGTLIIKSQ GLADFSNGFK GATNFSLVAA GVNINNVDSS TNDKFTKKSG TSMAAPMVSG
TAALVKQNFP FLDGKQIADI LLSTANKNYK APKFTVKQVT DGTNQPKFLI VYISQDPPGI
EDEIKRDLKQ LYNGIQVQVN GQWIDYSDYI WDNRDSAQSQ KLNTSTISSI NGVVRVEKEE
LFGQGILDAQ KALKGLSILD ANRLSDQDVL KYEQEPNTAY YTINTAGYDA EFSNDISQRK
WDESTHLSSA INKPTHLANL NIGLSKEGEG ILIISGQNTY EGATLIKQGE LKLKGKVKNN
AYVEQKAILS GNGIVGQNLN NKGIVRPGNE DLNDLTVQGT YTQEGVDSKL QLDFGNYKNS
KLIAKTYDIK SGNLEYIPLP KYYILNKPVK INLGDLEKSL SSFNHVLIQN TYALNFDFVL
SDDLVSINKT LIKPNLKPNA YEIPNTSLGN ALRQLRSRAD LSQTYQEFFA SLDNGIDVKT
KLNRIEGSGY LSTFSNHNQS NLMQNNMLFT LHPLNINNFA QNNNILLAST YLPRIFSNEE
YFWHLTPSYK YYKDKDFSGQ KTGANISLGE NFSSGFLAYA LSLSSAKFNF NNGSDLKSYN
MDLLLNYNHD LDFIKILSGL GIGVGFNTLN RFVVEQPIEG KYKTLQTSAQ LGVTKDIILG
QDFIFNPLMY FTHSFFYQED FKENKSPFAK NYESLKHHSI NANLGFNLAK NIEQDDYQAS
FSTFVIFEKR IYGRTLENKA SFVDFPIAFI QKYKLKDNIL SQGFNSEFLY KNNVFWQFML
MNRFSHNAYE LHLMSSVGKR F
//
