ID CISY_GLOMM Reviewed; 465 AA.
AC Q0QHL3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 06-MAR-2013, entry version 30.
DE RecName: Full=Probable citrate synthase, mitochondrial;
DE EC=2.3.3.1;
DE Flags: Precursor;
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Hippoboscoidea; Glossinidae; Glossina.
OX NCBI_TaxID=37546;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fat body;
RX PubMed=16907828; DOI=10.1111/j.1365-2583.2006.00649.x;
RA Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E.,
RA Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.;
RT "Analysis of fat body transcriptome from the adult tsetse fly,
RT Glossina morsitans morsitans.";
RL Insect Mol. Biol. 15:411-424(2006).
CC -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC CoA.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC isocitrate from oxaloacetate: step 1/2.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC capable of oxidative metabolism.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
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DR EMBL; DQ374006; ABG77984.1; -; mRNA.
DR ProteinModelPortal; Q0QHL3; -.
DR SMR; Q0QHL3; 30-463.
DR UniPathway; UPA00223; UER00717.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; ISS:UniProtKB.
DR GO; GO:0005975; P:carbohydrate metabolic process; ISS:UniProtKB.
DR GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; -; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR002020; Citrate_synthase-like.
DR InterPro; IPR016141; Citrate_synthase-like_core.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR010109; Citrate_synthase_euk.
DR PANTHER; PTHR11739; PTHR11739; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate_synthase_core; 1.
DR TIGRFAMs; TIGR01793; cit_synth_euk; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Transferase; Transit peptide; Tricarboxylic acid cycle.
FT TRANSIT 1 ? Mitochondrion (Potential).
FT CHAIN ? 465 Probable citrate synthase, mitochondrial.
FT /FTId=PRO_0000291557.
FT ACT_SITE 303 303 By similarity.
FT ACT_SITE 349 349 By similarity.
FT ACT_SITE 404 404 By similarity.
SQ SEQUENCE 465 AA; 51864 MW; 8584A6B0BA0E84C6 CRC64;
MSIYRISTTR KMPEVQKLNA LLASYVRFIS ADSSLRDVLA AKIPAEQERV KNFRKQHGSF
KMGETTVDMM YGGMRGIKAL VTETSVLDAD EGIRFRGLSI PECQKVLPAA DGGEEPLPEG
LFWLLLTGEV PSKAQVKQVS REWAARAALP QHVVTMLNNF PTSLHPMSQF SAAITALNHD
SKFAKAYSDG VHKSKYWEHV YEDSMDLIAK LPVVAATIYC NTYRNGKGSK SIDSSLDWSA
NFVKMLGYDD PKFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG
PLHGLANQEV LVWLRKLQKE AGSNPSEEQL KEYIWKTLKS GQVVPGYGHA VLRKTDPRYT
CQREFALKHL PNDELFQLVS KIYKVVPPIL QETGKVKNPW PNVDAHSGVL LQYYGMKEMN
YYTVLFGVSR ALGVLASLVW DRALGLPIER PKSLSTDLLM KMVQK
//
