GenomeNet

Database: UniProt
Entry: Q0QHL3
LinkDB: Q0QHL3
Original site: Q0QHL3 
ID   CISY_GLOMM              Reviewed;         465 AA.
AC   Q0QHL3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-OCT-2013, entry version 31.
DE   RecName: Full=Probable citrate synthase, mitochondrial;
DE            EC=2.3.3.1;
DE   Flags: Precursor;
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Hippoboscoidea; Glossinidae; Glossina.
OX   NCBI_TaxID=37546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fat body;
RX   PubMed=16907828; DOI=10.1111/j.1365-2583.2006.00649.x;
RA   Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E.,
RA   Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.;
RT   "Analysis of fat body transcriptome from the adult tsetse fly,
RT   Glossina morsitans morsitans.";
RL   Insect Mol. Biol. 15:411-424(2006).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC       CoA.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC       capable of oxidative metabolism.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DQ374006; ABG77984.1; -; mRNA.
DR   ProteinModelPortal; Q0QHL3; -.
DR   SMR; Q0QHL3; 30-463.
DR   UniPathway; UPA00223; UER00717.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; ISS:UniProtKB.
DR   GO; GO:0005975; P:carbohydrate metabolic process; ISS:UniProtKB.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR002020; Citrate_synthase-like.
DR   InterPro; IPR016141; Citrate_synthase-like_core.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR010109; Citrate_synthase_euk.
DR   PANTHER; PTHR11739; PTHR11739; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01793; cit_synth_euk; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Transferase; Transit peptide; Tricarboxylic acid cycle.
FT   TRANSIT       1      ?       Mitochondrion (Potential).
FT   CHAIN         ?    465       Probable citrate synthase, mitochondrial.
FT                                /FTId=PRO_0000291557.
FT   ACT_SITE    303    303       By similarity.
FT   ACT_SITE    349    349       By similarity.
FT   ACT_SITE    404    404       By similarity.
SQ   SEQUENCE   465 AA;  51864 MW;  8584A6B0BA0E84C6 CRC64;
     MSIYRISTTR KMPEVQKLNA LLASYVRFIS ADSSLRDVLA AKIPAEQERV KNFRKQHGSF
     KMGETTVDMM YGGMRGIKAL VTETSVLDAD EGIRFRGLSI PECQKVLPAA DGGEEPLPEG
     LFWLLLTGEV PSKAQVKQVS REWAARAALP QHVVTMLNNF PTSLHPMSQF SAAITALNHD
     SKFAKAYSDG VHKSKYWEHV YEDSMDLIAK LPVVAATIYC NTYRNGKGSK SIDSSLDWSA
     NFVKMLGYDD PKFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG
     PLHGLANQEV LVWLRKLQKE AGSNPSEEQL KEYIWKTLKS GQVVPGYGHA VLRKTDPRYT
     CQREFALKHL PNDELFQLVS KIYKVVPPIL QETGKVKNPW PNVDAHSGVL LQYYGMKEMN
     YYTVLFGVSR ALGVLASLVW DRALGLPIER PKSLSTDLLM KMVQK
//
DBGET integrated database retrieval system