ID   Q0RI85_FRAAA            Unreviewed;      1068 AA.
AC   Q0RI85;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   OrderedLocusNames=FRAAL4144 {ECO:0000313|EMBL:CAJ62786.1};
OS   Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ62786.1, ECO:0000313|Proteomes:UP000000657};
RN   [1] {ECO:0000313|EMBL:CAJ62786.1, ECO:0000313|Proteomes:UP000000657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACN14a {ECO:0000313|Proteomes:UP000000657};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
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DR   EMBL; CT573213; CAJ62786.1; -; Genomic_DNA.
DR   RefSeq; WP_011605272.1; NC_008278.1.
DR   AlphaFoldDB; Q0RI85; -.
DR   STRING; 326424.FRAAL4144; -.
DR   KEGG; fal:FRAAL4144; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG3903; Bacteria.
DR   HOGENOM; CLU_000288_125_8_11; -.
DR   OrthoDB; 3885120at2; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46082:SF6; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR46082; ATP/GTP-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   Pfam; PF13374; TPR_10; 4.
DR   Pfam; PF13424; TPR_12; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000657}.
FT   DOMAIN          12..122
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
FT   REGION          138..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1042..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1042..1059
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1068 AA;  113762 MW;  9D078E2F11AB8096 CRC64;
     MTGGGDGRAL DVFVSCAADG LGWAEWIAAT LEDAGHRVQL GAWDAVPGTH RVSWLDGVTR
     RASHTIAVVS DGYLDSPTAP AEWGAAWSPR IMGGERRLLV ARVTDRPIPG LLGQLVPIDL
     IGRSPLAAQT MLLAATRGEA PPGEAGRGAV GWGETARGGA TLGEAGDGRR LPDRQGASGG
     VVFPGELPAV WNVPRVAARF VGRAPALGRL DEAMARDGGL VAVTGLAGIG KTRLAVEYVH
     QQRRGFDAVW WVPAGRPELV GERVRALAPA LGLPAQAEPA AVLARLDAAD GRWLLVLDDA
     AGPGELPGWL RASSGAGRIL VTSRIDGWDD AGVVVPLGPM ERAESVALLT DRLPAVERTV
     AGRIADRLGD HPLALDQAAH RIREARAPAE TYLAALIERP AVVLGQGEVP GRPGVTAATL
     WAEPLRRLEA DAPAAGELLR LAAHGDGSAP LPLRLLAADP EAIDGGALRA VAGDPLELAD
     TVATLERSGL AHRDGFALAV HPLVRAAVRA DTSAEHADRL AATLGRALHA TLPEDVIANP
     QAWPAWRELL PHVLGTVEAT DSTADTPHTA WLAEHAAAYL TEQGHPEQAE PLAARAVAAH
     ERLDGADHPD TLTARETHIR AALNADHLAV AGPLAERNAT DRERLLGPDH PDTLTSRETL
     ARAYQQAGHL DHATDLFQQN LADRHRVLGP DHPATLESRH RLGAALDDAG RGDDATRILR
     PTLTDRERLL GADHPDTLTT RHQLAATYRR IGATGDAVAH AEPTLTARER VLGPDHPHTL
     DSRHQLGVTY HQAGRVDDAT RELGQALTGR ERILGPDHPG TFESAHALAR THLRAGRPES
     AVPLLDRALT GRERTLGSDH PETTETRESL AAAHLAEGRP GEAVIHLERV LDRHERVLGQ
     AHLYAMEVRD DLAAHYRDAG QPEAARHHLE RQLVARARTD GVADERTLCT ATGLAEVCRD
     TGRLTQAVDL SERVHALRAH TLGPDHPETR ASRTTLADTY RQAGRHADAA PLNRDALTDA
     MRDHGPYHPD TIHARRALTD TIHHQSAEKP PRPERSPAAD IGESRVGP
//