ID Q0S396_RHOJR Unreviewed; 517 AA.
AC Q0S396;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Possible DNA-directed DNA polymerase {ECO:0000313|EMBL:ABG97990.1};
GN OrderedLocusNames=RHA1_ro06213 {ECO:0000313|EMBL:ABG97990.1};
OS Rhodococcus jostii (strain RHA1).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG97990.1, ECO:0000313|Proteomes:UP000008710};
RN [1] {ECO:0000313|Proteomes:UP000008710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710};
RX PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA Eltis L.D.;
RT "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT catabolic powerhouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CP000431; ABG97990.1; -; Genomic_DNA.
DR RefSeq; WP_011598189.1; NC_008268.1.
DR AlphaFoldDB; Q0S396; -.
DR KEGG; rha:RHA1_ro06213; -.
DR PATRIC; fig|101510.16.peg.6261; -.
DR eggNOG; COG0389; Bacteria.
DR HOGENOM; CLU_026357_0_0_11; -.
DR OrthoDB; 5244088at2; -.
DR Proteomes; UP000008710; Chromosome.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd03468; PolY_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF00817; IMS; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:ABG97990.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABG97990.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008710};
KW Transferase {ECO:0000313|EMBL:ABG97990.1}.
FT DOMAIN 28..151
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 221..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 54993 MW; 26C4D968DA79E293 CRC64;
MSRVLALWCP DWPAVAAAAA ADLPPTHPVA VTSGNRVIAC SAPARADGVR RGLRRREAQA
RCPRLHVVTA DPDRDARLFE AVASAVDAVA PGVEVLRPGL VVLSARGVAR YFGSEEAAAE
RLVDQVSAVG VECQVGIADQ LSTAVIAARR ATLVPPGEGT AFLAPLPMRE LAAEPSLAAP
HRGELVDLLH RLGLRTIGSF AALSAGDVAS RFGTDAVLAH RAARSEPERP PSGRSLPPDL
EVEERCDPVI ERVDAAAFAG RALAEKLHRT LSDAAVACTR LSISASTGNG EQLSRIWRCA
EPLTPEATAD RVRWQLDGWL TGRSEKRPSA GIAVLRLEPV EVVAAGALQL GLWGGVGDRD
ERARRALVRV QGLLGGEAVQ VGVLSGGRGP AERITLLPLG DELIPRNDPS EPWPGTLPEP
APAAVLTAYP EVWMSDERGM AVTVTERGVF SAPPARLRWG SREWAVCGWA GPWPVDERWW
DPPAARTAAR AQVLLEESRA LLVICTAGRW SVEGIYE
//
