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Database: UniProt
Entry: Q0SG15
LinkDB: Q0SG15
Original site: Q0SG15 
ID   NHAA1_RHOSR             Reviewed;         622 AA.
AC   Q0SG15;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   14-MAY-2014, entry version 64.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA 1;
DE   AltName: Full=Sodium/proton antiporter NhaA 1;
GN   Name=nhaA1; OrderedLocusNames=RHA1_ro01708;
OS   Rhodococcus sp. (strain RHA1).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1;
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M.,
RA   Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D.,
RA   Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M.,
RA   Schein J.E., Shin H., Smailus D., Siddiqui A.S., Marra M.A.,
RA   Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M.,
RA   Davies J.E., Mohn W.W., Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the NhaA
CC       Na(+)/H(+) (TC 2.A.33) antiporter family.
CC   -!- SIMILARITY: Contains 1 thioredoxin domain.
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DR   EMBL; CP000431; ABG93521.1; -; Genomic_DNA.
DR   RefSeq; YP_701679.1; NC_008268.1.
DR   ProteinModelPortal; Q0SG15; -.
DR   STRING; 101510.RHA1_ro01708; -.
DR   PRIDE; Q0SG15; -.
DR   EnsemblBacteria; ABG93521; ABG93521; RHA1_ro01708.
DR   GeneID; 4218931; -.
DR   KEGG; rha:RHA1_ro01708; -.
DR   PATRIC; 23202249; VBIRhoJos26306_1730.
DR   eggNOG; COG3004; -.
DR   HOGENOM; HOG000218489; -.
DR   OMA; RYVWRHL; -.
DR   OrthoDB; EOG64FKCC; -.
DR   BioCyc; RJOS101510:GJJ1-1707-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 2.
DR   Gene3D; 3.40.30.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom.
DR   InterPro; IPR004670; NhaA.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   Pfam; PF13462; Thioredoxin_4; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Complete proteome; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    622       Na(+)/H(+) antiporter NhaA 1.
FT                                /FTId=PRO_0000334485.
FT   TRANSMEM     30     50       Helical; (Potential).
FT   TRANSMEM     73     93       Helical; (Potential).
FT   TRANSMEM    109    129       Helical; (Potential).
FT   TRANSMEM    138    158       Helical; (Potential).
FT   TRANSMEM    167    187       Helical; (Potential).
FT   TRANSMEM    190    210       Helical; (Potential).
FT   TRANSMEM    230    250       Helical; (Potential).
FT   TRANSMEM    303    323       Helical; (Potential).
FT   TRANSMEM    337    357       Helical; (Potential).
FT   TRANSMEM    374    394       Helical; (Potential).
FT   TRANSMEM    407    427       Helical; (Potential).
FT   DOMAIN      430    617       Thioredoxin.
FT   REGION        1    429       Na(+)/H(+) antiporter NhaA.
SQ   SEQUENCE   622 AA;  67068 MW;  8A6CD0F750AED50F CRC64;
     MTVEQSSPTT LRRLSARLAL IRDDTDDDKL SAGFLLVATI LALVWANIGD SYESFWHTPV
     TIQISDNSIS LDLKHWVNDG LMTLFFFVVG LEVKRELTIG ELTDRARAAV PLLAAIAGLA
     LPAVLFLILN PSGDEATAWG VVVSTDTAFV LGALALVGPR CPARLRVFIL TLAVADDIGA
     LALIAFFYTD DLRLGPLLLG CVGLLLIIQL RKLEVWRGVA YFIVAAGTWV AFYESGVHPT
     LVGVLIALIL PVYPPRRSEV ERAGELTRAF RQSPNSDYAR AAQLGVLRAV SVNERLLRFY
     QPYTAFLVVP IFALANAGVV ITGQTLADAA RSPLAWGIVL GLVVGKLVGI TAATALFSKL
     RPGSLPPGLT LSQIAGGSAL AGIGFTISLF IVDLAIDSPE LANEARVGVL TAAVIATVLG
     WALFRLSDTV HPPTEVVGLT LLRPVDPGRD HLRGPADAPL TLVEYGDFEC PFCSKATGSI
     RDVRAHFGDE LRYVFRHLPL DDVHPHARFA AQASEAAAAQ GRFWEMHDHL FANSDALAED
     EIFGYAAELG LDMDRFEEDI RRGTYVHRID DDELDAESSD FRGTPTFYLG ATGTDLARHS
     GPYDAATLIR KLEEARGADG AP
//
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