ID NHAA1_RHOSR Reviewed; 622 AA.
AC Q0SG15;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 01-MAY-2013, entry version 57.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 1;
DE AltName: Full=Sodium/proton antiporter NhaA 1;
GN Name=nhaA1; OrderedLocusNames=RHA1_ro01708;
OS Rhodococcus sp. (strain RHA1).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Nocardiaceae; Rhodococcus.
OX NCBI_TaxID=101510;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RHA1;
RX PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M.,
RA Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D.,
RA Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M.,
RA Schein J.E., Shin H., Smailus D., Siddiqui A.S., Marra M.A.,
RA Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M.,
RA Davies J.E., Mohn W.W., Eltis L.D.;
RT "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT catabolic powerhouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC for external protons (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (By similarity).
CC -!- SIMILARITY: In the N-terminal section; belongs to the NhaA
CC Na(+)/H(+) (TC 2.A.33) antiporter family.
CC -!- SIMILARITY: Contains 1 thioredoxin domain.
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DR EMBL; CP000431; ABG93521.1; -; Genomic_DNA.
DR RefSeq; YP_701679.1; NC_008268.1.
DR ProteinModelPortal; Q0SG15; -.
DR STRING; 101510.RHA1_ro01708; -.
DR EnsemblBacteria; ABG93521; ABG93521; RHA1_ro01708.
DR GeneID; 4218931; -.
DR KEGG; rha:RHA1_ro01708; -.
DR PATRIC; 23202249; VBIRhoJos26306_1730.
DR eggNOG; COG3004; -.
DR HOGENOM; HOG000218489; -.
DR OMA; FRQSPNS; -.
DR ProtClustDB; CLSK901892; -.
DR BioCyc; RJOS101510:GJJ1-1707-MONOMER; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:HAMAP.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:HAMAP.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:GOC.
DR Gene3D; 1.20.1530.10; -; 2.
DR Gene3D; 3.40.30.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1; fused.
DR InterPro; IPR023171; Na/H_antiporter_dom.
DR InterPro; IPR004670; NhaA.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; FALSE_NEG.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Complete proteome; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 622 Na(+)/H(+) antiporter NhaA 1.
FT /FTId=PRO_0000334485.
FT TRANSMEM 30 50 Helical; (Potential).
FT TRANSMEM 73 93 Helical; (Potential).
FT TRANSMEM 109 129 Helical; (Potential).
FT TRANSMEM 138 158 Helical; (Potential).
FT TRANSMEM 167 187 Helical; (Potential).
FT TRANSMEM 190 210 Helical; (Potential).
FT TRANSMEM 230 250 Helical; (Potential).
FT TRANSMEM 303 323 Helical; (Potential).
FT TRANSMEM 337 357 Helical; (Potential).
FT TRANSMEM 374 394 Helical; (Potential).
FT TRANSMEM 407 427 Helical; (Potential).
FT DOMAIN 430 617 Thioredoxin.
FT REGION 1 429 Na(+)/H(+) antiporter NhaA.
SQ SEQUENCE 622 AA; 67068 MW; 8A6CD0F750AED50F CRC64;
MTVEQSSPTT LRRLSARLAL IRDDTDDDKL SAGFLLVATI LALVWANIGD SYESFWHTPV
TIQISDNSIS LDLKHWVNDG LMTLFFFVVG LEVKRELTIG ELTDRARAAV PLLAAIAGLA
LPAVLFLILN PSGDEATAWG VVVSTDTAFV LGALALVGPR CPARLRVFIL TLAVADDIGA
LALIAFFYTD DLRLGPLLLG CVGLLLIIQL RKLEVWRGVA YFIVAAGTWV AFYESGVHPT
LVGVLIALIL PVYPPRRSEV ERAGELTRAF RQSPNSDYAR AAQLGVLRAV SVNERLLRFY
QPYTAFLVVP IFALANAGVV ITGQTLADAA RSPLAWGIVL GLVVGKLVGI TAATALFSKL
RPGSLPPGLT LSQIAGGSAL AGIGFTISLF IVDLAIDSPE LANEARVGVL TAAVIATVLG
WALFRLSDTV HPPTEVVGLT LLRPVDPGRD HLRGPADAPL TLVEYGDFEC PFCSKATGSI
RDVRAHFGDE LRYVFRHLPL DDVHPHARFA AQASEAAAAQ GRFWEMHDHL FANSDALAED
EIFGYAAELG LDMDRFEEDI RRGTYVHRID DDELDAESSD FRGTPTFYLG ATGTDLARHS
GPYDAATLIR KLEEARGADG AP
//
