ID DBP4_PHANO Reviewed; 803 AA.
AC Q0UMB9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 29-MAY-2013, entry version 44.
DE RecName: Full=ATP-dependent RNA helicase DBP4;
DE EC=3.6.4.13;
GN Name=DBP4; ORFNames=SNOG_07095;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
OS (Glume blotch fungus) (Septoria nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
OC Phaeosphaeriaceae; Phaeosphaeria.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing
RT and EST analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: ATP-dependent RNA helicase required for ribosome
CC biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal
CC complexes. Required for pre-rRNA cleavage at site A2 (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC -!- SUBUNIT: Interacts with the U3 and U14 snoRNAs. Associates with
CC pre-ribosomal complexes (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity).
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC box family of RNA helicases and controls ATP binding and
CC hydrolysis.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX10/DBP4
CC subfamily.
CC -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC -!- SIMILARITY: Contains 1 helicase C-terminal domain.
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DR EMBL; CH445334; EAT85746.1; -; Genomic_DNA.
DR RefSeq; XP_001797448.1; XM_001797396.1.
DR ProteinModelPortal; Q0UMB9; -.
DR SMR; Q0UMB9; 51-259.
DR EnsemblFungi; SNOT_07095; SNOT_07095; SNOG_07095.
DR GeneID; 5973938; -.
DR KEGG; pno:SNOG_07095; -.
DR KO; K14776; -.
DR OMA; MFERKNQ; -.
DR OrthoDB; EOG4R53B0; -.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR InterPro; IPR025313; DUF4217.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF13959; DUF4217; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Helicase; Hydrolase;
KW Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW RNA-binding; rRNA processing.
FT CHAIN 1 803 ATP-dependent RNA helicase DBP4.
FT /FTId=PRO_0000256003.
FT DOMAIN 80 256 Helicase ATP-binding.
FT DOMAIN 269 441 Helicase C-terminal.
FT NP_BIND 93 100 ATP (By similarity).
FT MOTIF 49 77 Q motif.
FT MOTIF 204 207 DEAD box.
SQ SEQUENCE 803 AA; 90190 MW; 54ABD87430285A41 CRC64;
MGAPGITGRT RPTKVKKQAS QQKRKRDDVD VEKLEQAVTE LDPKTGTYND FSDLPLSDPT
KQGLKACHFA VMTDIQRKAV PLALKGHDIL GAAKTGSGKT LSFIIPVLEN LYRLQHVGAD
AGLGALILSP TRELAIQIFD VLCKIGKHGH MFAAGLLIGG KSLESERQAL PRMNILVATP
GRMLQHLSQT AAFLVDDLKM LVLDEADRIL DMGFQRDVDA IIDYLPKERQ TLLFSATQSK
KVSDLARLSL QDPEYVSVHA EDKSATPKSL QQNYIICPLE EKLDTLWSFI QASKKSKILV
FFSSAKAVRF VYESFRHMQP GIPLLHIHGR QKQGARLDTT AKFSSAKNSC LFATDVAARG
LDFPAVDFVI QVDCPDDVDT YIHRVGRTAR YNREGRGVLF LAPSEEEGML KRLEAKKVPV
EAINVRQKKR QSIKEQLQNM CFQDPALKYL GQKAFMTYVK SVYLQKDKEV FQLKEYDLEA
FAASLGLPGT PRIKFLKDDN SKQKKQASRQ TIEVSDSDEE EAPKAEKPVR TKYDRMFERK
NQDVLAEHYK KLVRDGDEEI SAPANDFSGE ATTNGADDDF LAIKRRIPAD DEDEDFGGEA
SVAPGGRVVH LAGASQPLII DSNRREKLLQ SKKKLTKLMD RGKKLVYDDD GNPHEVYELE
TEADFKAKGL PEHQRQKFIE AAREVVQTAD VEDKATARAK RKEKLRKRKE RERGEAEDDG
DEAVELEDTG ENPLANFLAD AQYTDDEQEE VEQPKKKEKK WFQSDSEDEE KSSKKKRKKA
KQQVVEEPET LEDMEALAAG LLG
//
