ID Q0V9E4_XENTR Unreviewed; 209 AA.
AC Q0V9E4; A0A6I8QHI3;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Natural cytotoxicity triggering receptor 3 {ECO:0000256|ARBA:ARBA00019135};
DE AltName: Full=Natural killer cell p30-related protein {ECO:0000256|ARBA:ARBA00032296};
GN Name=MGC147231 {ECO:0000313|EMBL:AAI21610.1,
GN ECO:0000313|Ensembl:ENSXETP00000068018,
GN ECO:0000313|RefSeq:NP_001072401.1,
GN ECO:0000313|Xenbase:XB-GENE-5753296};
GN Synonyms=mgc147231 {ECO:0000313|Xenbase:XB-GENE-5753296};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI21610.1};
RN [1] {ECO:0000313|RefSeq:NP_001072401.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI21610.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6 {ECO:0000313|EMBL:AAI21610.1};
RC TISSUE=Ovary {ECO:0000313|EMBL:AAI21610.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000068018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000068018};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000068018}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001072401.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer in the unliganted form. Interacts with CD3Z.
CC Interacts with and is activated by binding to NCR3LG1. Interacts with
CC and is activated by binding to BAG6. {ECO:0000256|ARBA:ARBA00011456}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000256|ARBA:ARBA00006531}.
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DR EMBL; BC121609; AAI21610.1; -; mRNA.
DR RefSeq; NP_001072401.1; NM_001078933.1.
DR DNASU; 779855; -.
DR Ensembl; ENSXETT00000078710; ENSXETP00000068018; ENSXETG00000039158.
DR GeneID; 779855; -.
DR KEGG; xtr:779855; -.
DR AGR; Xenbase:XB-GENE-5753296; -.
DR Xenbase; XB-GENE-5753296; MGC147231.
DR OMA; EEMICAY; -.
DR OrthoDB; 4593793at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000039158; Expressed in ovary.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR043226; NCR3.
DR PANTHER; PTHR47904; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; 1.
DR PANTHER; PTHR47904:SF2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..209
FT /note="Natural cytotoxicity triggering receptor 3"
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001072401.1"
FT /id="PRO_5033206352"
FT TRANSMEM 148..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..125
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 209 AA; 22988 MW; 370206AE3124E478 CRC64;
MRGLALLLLL GALRGCLLQN IRVSQIPAVS ATEGSTVTLQ CHYTLSSTEN GSLGWYRWYR
HVLGGPEVSN NSRNYTGRVS SACQSDCSSE FINNRSASIQ LHRVQIPDTG VYICEVALEL
SRTLQGHGNG TFLNVTVTVS TSWGRFTLYH WIGAGALGLL MSFALYLNCK EHKQVISGEE
MICAYKKQAN MDPTNCTEQL GEEIVYSTV
//
