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Database: UniProt
Entry: Q0VA82
LinkDB: Q0VA82
Original site: Q0VA82 
ID   MFSD8_DANRE             Reviewed;         504 AA.
AC   Q0VA82;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   01-OCT-2014, entry version 53.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 8;
GN   Name=mfsd8; ORFNames=zgc:136865;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a carrier that transport small solutes by using
CC       chemiosmotic ion gradients. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Sorting to lysosomes involves
CC       tyrosine- and/or dileucine-based motifs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC121197; AAI21198.1; -; mRNA.
DR   RefSeq; NP_001038513.1; NM_001045048.1.
DR   UniGene; Dr.76521; -.
DR   ProteinModelPortal; Q0VA82; -.
DR   STRING; 7955.ENSDARP00000050073; -.
DR   GeneID; 564342; -.
DR   KEGG; dre:564342; -.
DR   CTD; 256471; -.
DR   ZFIN; ZDB-GENE-060818-29; mfsd8.
DR   eggNOG; COG0477; -.
DR   HOGENOM; HOG000047970; -.
DR   HOVERGEN; HBG061584; -.
DR   InParanoid; Q0VA82; -.
DR   KO; K12307; -.
DR   PhylomeDB; Q0VA82; -.
DR   NextBio; 20885331; -.
DR   PRO; PR:Q0VA82; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Lysosome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    504       Major facilitator superfamily domain-
FT                                containing protein 8.
FT                                /FTId=PRO_0000311234.
FT   TOPO_DOM      1     32       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     33     53       Helical. {ECO:0000255}.
FT   TOPO_DOM     54     66       Extracellular. {ECO:0000255}.
FT   TRANSMEM     67     87       Helical. {ECO:0000255}.
FT   TOPO_DOM     88     97       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     98    118       Helical. {ECO:0000255}.
FT   TOPO_DOM    119    123       Extracellular. {ECO:0000255}.
FT   TRANSMEM    124    144       Helical. {ECO:0000255}.
FT   TOPO_DOM    145    169       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    170    190       Helical. {ECO:0000255}.
FT   TOPO_DOM    191    203       Extracellular. {ECO:0000255}.
FT   TRANSMEM    204    224       Helical. {ECO:0000255}.
FT   TOPO_DOM    225    258       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    259    279       Helical. {ECO:0000255}.
FT   TOPO_DOM    280    302       Extracellular. {ECO:0000255}.
FT   TRANSMEM    303    323       Helical. {ECO:0000255}.
FT   TOPO_DOM    324    330       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    331    351       Helical. {ECO:0000255}.
FT   TOPO_DOM    352    468       Extracellular. {ECO:0000255}.
FT   TRANSMEM    469    489       Helical. {ECO:0000255}.
FT   TOPO_DOM    490    504       Cytoplasmic. {ECO:0000255}.
FT   MOTIF        12     13       Dileucine internalization motif.
FT                                {ECO:0000250}.
FT   CARBOHYD    364    364       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   504 AA;  55486 MW;  BEBDBE6F3E94AFC0 CRC64;
     MPLEESGENT PLLRGEIISD GDTDRSRWRS IRVMYFTMFL SSVGFTIVIT SIWPYLKKID
     ESADASFLGW VVAAYSLGQM VASPFFGLWS NHRPRREPLV CSIFINVSAN IYYSYVYLPP
     SHNQIHMLLA RTFVGIGAGN VAVVRSYVAG ATSLKERTSA MANMSACQAL GFILGPALQA
     VLSFIGETGV SVDVIKLQVN MYTAPALLAA CFGVINILLV ILVLREHSVD DHGNRIRPIN
     YTPEERVDVP PEVEGDIDHI AVFTSNVLFF IILFIFAVFE TISTPLSMDM FAWTRKEAVL
     YNGIILAAIG FESILVFLVV KVVSARVGDR PLLLGGLILI FVGFFMLLPW GNQYPKIQWT
     DINNNTIPPI QLAPTPASNS SLEPIGCPSE QTWCLFTPVI HLAQYITSDI LIGVGYPTCN
     VMSYTLYSKI LGPKPQGVYM GWLTASGSGA RTLGPVFVSH FYTILGPRWA FSAICGIVLA
     AIVMLSAMYK RLVAFSIRHG RIAE
//
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