ID MFSD8_DANRE Reviewed; 504 AA.
AC Q0VA82;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-APR-2013, entry version 46.
DE RecName: Full=Major facilitator superfamily domain-containing protein 8;
GN Name=mfsd8; ORFNames=zgc:136865;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a carrier that transport small solutes by using
CC chemiosmotic ion gradients (Potential).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
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DR EMBL; BC121197; AAI21198.1; -; mRNA.
DR IPI; IPI00488229; -.
DR RefSeq; NP_001038513.1; NM_001045048.1.
DR UniGene; Dr.76521; -.
DR ProteinModelPortal; Q0VA82; -.
DR STRING; 7955.ENSDARP00000050073; -.
DR GeneID; 564342; -.
DR KEGG; dre:564342; -.
DR CTD; 256471; -.
DR ZFIN; ZDB-GENE-060818-29; mfsd8.
DR eggNOG; COG0477; -.
DR HOGENOM; HOG000047970; -.
DR HOVERGEN; HBG061584; -.
DR InParanoid; Q0VA82; -.
DR KO; K12307; -.
DR OrthoDB; EOG40CHH4; -.
DR NextBio; 20885331; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Lysosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 504 Major facilitator superfamily domain-
FT containing protein 8.
FT /FTId=PRO_0000311234.
FT TOPO_DOM 1 32 Cytoplasmic (Potential).
FT TRANSMEM 33 53 Helical; (Potential).
FT TOPO_DOM 54 66 Extracellular (Potential).
FT TRANSMEM 67 87 Helical; (Potential).
FT TOPO_DOM 88 97 Cytoplasmic (Potential).
FT TRANSMEM 98 118 Helical; (Potential).
FT TOPO_DOM 119 123 Extracellular (Potential).
FT TRANSMEM 124 144 Helical; (Potential).
FT TOPO_DOM 145 169 Cytoplasmic (Potential).
FT TRANSMEM 170 190 Helical; (Potential).
FT TOPO_DOM 191 203 Extracellular (Potential).
FT TRANSMEM 204 224 Helical; (Potential).
FT TOPO_DOM 225 258 Cytoplasmic (Potential).
FT TRANSMEM 259 279 Helical; (Potential).
FT TOPO_DOM 280 302 Extracellular (Potential).
FT TRANSMEM 303 323 Helical; (Potential).
FT TOPO_DOM 324 330 Cytoplasmic (Potential).
FT TRANSMEM 331 351 Helical; (Potential).
FT TOPO_DOM 352 468 Extracellular (Potential).
FT TRANSMEM 469 489 Helical; (Potential).
FT TOPO_DOM 490 504 Cytoplasmic (Potential).
SQ SEQUENCE 504 AA; 55486 MW; BEBDBE6F3E94AFC0 CRC64;
MPLEESGENT PLLRGEIISD GDTDRSRWRS IRVMYFTMFL SSVGFTIVIT SIWPYLKKID
ESADASFLGW VVAAYSLGQM VASPFFGLWS NHRPRREPLV CSIFINVSAN IYYSYVYLPP
SHNQIHMLLA RTFVGIGAGN VAVVRSYVAG ATSLKERTSA MANMSACQAL GFILGPALQA
VLSFIGETGV SVDVIKLQVN MYTAPALLAA CFGVINILLV ILVLREHSVD DHGNRIRPIN
YTPEERVDVP PEVEGDIDHI AVFTSNVLFF IILFIFAVFE TISTPLSMDM FAWTRKEAVL
YNGIILAAIG FESILVFLVV KVVSARVGDR PLLLGGLILI FVGFFMLLPW GNQYPKIQWT
DINNNTIPPI QLAPTPASNS SLEPIGCPSE QTWCLFTPVI HLAQYITSDI LIGVGYPTCN
VMSYTLYSKI LGPKPQGVYM GWLTASGSGA RTLGPVFVSH FYTILGPRWA FSAICGIVLA
AIVMLSAMYK RLVAFSIRHG RIAE
//
