ID Q0VBA6_MOUSE Unreviewed; 360 AA.
AC Q0VBA6;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 22-FEB-2023, entry version 118.
DE SubName: Full=Hydroxycarboxylic acid receptor 2 {ECO:0000313|EMBL:APT70323.1};
DE SubName: Full=Niacin receptor 1 {ECO:0000313|EMBL:AAI20716.1};
GN Name=Hcar2 {ECO:0000313|MGI:MGI:1933383};
GN Synonyms=Gpr109a {ECO:0000313|MGI:MGI:1933383}, HCAR2
GN {ECO:0000313|EMBL:APT70323.1}, Niacr1 {ECO:0000313|EMBL:AAI20716.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI20716.1};
RN [1] {ECO:0000313|EMBL:AAI20716.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI20716.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|EMBL:APT70323.1}
RP NUCLEOTIDE SEQUENCE.
RA Peters A., Mueller A., Schoeneberg T., Staeubert C.;
RT "Evolution of the Hydroxycarboxylic acid GPCR family in apes.";
RL PLoS Genet. 0:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; BC120715; AAI20716.1; -; mRNA.
DR EMBL; BC125296; AAI25297.1; -; mRNA.
DR EMBL; KU285441; APT70323.1; -; Genomic_DNA.
DR RefSeq; NP_109626.1; NM_030701.3.
DR AlphaFoldDB; Q0VBA6; -.
DR SMR; Q0VBA6; -.
DR PeptideAtlas; Q0VBA6; -.
DR DNASU; 80885; -.
DR GeneID; 80885; -.
DR KEGG; mmu:80885; -.
DR AGR; MGI:1933383; -.
DR CTD; 338442; -.
DR MGI; MGI:1933383; Hcar2.
DR VEuPathDB; HostDB:ENSMUSG00000045502; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR OMA; KWDWKFG; -.
DR OrthoDB; 5354998at2759; -.
DR BioGRID-ORCS; 80885; 0 hits in 76 CRISPR screens.
DR ExpressionAtlas; Q0VBA6; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070553; F:nicotinic acid receptor activity; IEA:Ensembl.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR GO; GO:0070165; P:positive regulation of adiponectin secretion; IEA:Ensembl.
DR CDD; cd15201; 7tmA_HCAR1-3; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR46048; HYDROXYCARBOXYLIC ACID RECEPTOR 2; 1.
DR PANTHER; PTHR46048:SF6; HYDROXYCARBOXYLIC ACID RECEPTOR 2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..291
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 320..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 41401 MW; CCCE52A2475777FC CRC64;
MSKSDHFLVI NGKNCCVFRD ENIAKVLPPV LGLEFVFGLL GNGLALWIFC FHLKSWKSSR
IFLFNLAVAD FLLIICLPFL TDNYVHNWDW RFGGIPCRVM LFMLAMNRQG SIIFLTVVAV
DRYFRVVHPH HFLNKISNRT AAIISCFLWG LTIGLTVHLL YTNMMTKNGE AYLCSSFSIC
YNFRWHDAMF LLEFFLPLAI ILFCSGRIIW SLRQRQMDRH AKIKRAINFI MVVAIVFIIC
FLPSVAVRIR IFWLLYKYNV RNCDIYSSVD LAFFTTLSFT YMNSMLDPVV YYFSSPSFPN
FFSTCINRCL RKKTLGEPDN NRSTSVELTG DPSTTRSIPG ALMADPSEPG SPPYLASTSR
//