ID Q0VGP5_MOUSE Unreviewed; 687 AA.
AC Q0VGP5;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 22-FEB-2023, entry version 91.
DE SubName: Full=Ligand of numb-protein X 2 {ECO:0000313|EMBL:AAH90665.1};
GN Name=Lnx2 {ECO:0000313|EMBL:AAH90665.1, ECO:0000313|MGI:MGI:2155959};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH90665.1};
RN [1] {ECO:0000313|EMBL:AAH90665.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH90665.1};
RC TISSUE=Eye {ECO:0000313|EMBL:AAH90665.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; BC090665; AAH90665.1; -; mRNA.
DR AlphaFoldDB; Q0VGP5; -.
DR PeptideAtlas; Q0VGP5; -.
DR AGR; MGI:2155959; -.
DR MGI; MGI:2155959; Lnx2.
DR ChiTaRS; Lnx2; mouse.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16780; mRING-HC-C3HC3D_LNX2; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF33; LIGAND OF NUMB PROTEIN X 2; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 51..89
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 232..317
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 338..421
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 465..551
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 597..679
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 145..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 75151 MW; 57D1B83BA3ECD70B CRC64;
MGTTSDEMVP VEQASSTSSL DPLCFECGQQ HWARENHLYN YQGEVDDDLV CHICLQPLLQ
PLDTPCGHTF CHKCLRNFLQ EKDFCPLDRK RLHFKLCKKS SILVHKLLDK LLVLCPFSPV
CQDVMQRCDL EAHLKNRCPG ASHRRVDLER RKTSQTQTQI EGETGSTVID PPGTLPPETD
CSGTVPGERN LTPASLPVWT EEPGLDNPAF EESAAADSVQ QPLSLPEGEI TTIEIHRSNP
YIQLGISIVG GNETPLINIV IQEVYRDGVI ARDGRLLAGD QILQVNNYDI SNVSHNHARA
VLSQPCSTLQ LTVLRERRFG SRANSHADGS APRDEVFQVL LHKRDSTEQL GIKLVRRTDE
PGVFILDLLE GGLAAQDGRL NSNDRVLAIN GHHLKHGTPE LAAQIIQASG ERVNLTIARP
GKPQPSNGSR EAGAHSSSNH AQPPSHSRPG SHKDLTRCVT CQEKHITVKK EPHESLGMTV
AGGRGSKSGE LPIFVTSVPP HGCLARDGRI KRGDVLLNIN GIDLTNLSHS EAVAMLKASA
ASPAVILKAL EVQIAEEAAQ ATEEQPSAFS ENEYDASWSP SWVMWLGLPS ALHSCHDIVL
RRSYLGSWGF SIVGGYEENH TNQPFFIKTI VLGTPAYYDG RLKCGDMIVA VNGLSTVGMS
HSALVPMLKE QRNKVTLTVI CWPGSLV
//
