ID   Q0W4U2_METAR            Unreviewed;       431 AA.
AC   Q0W4U2;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:CAJ36601.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:CAJ36601.1};
GN   Name=tyrA {ECO:0000313|EMBL:CAJ36601.1};
GN   ORFNames=RCIX1314 {ECO:0000313|EMBL:CAJ36601.1};
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160 {ECO:0000313|EMBL:CAJ36601.1, ECO:0000313|Proteomes:UP000000663};
RN   [1] {ECO:0000313|EMBL:CAJ36601.1, ECO:0000313|Proteomes:UP000000663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50
RC   {ECO:0000313|Proteomes:UP000000663};
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
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DR   EMBL; AM114193; CAJ36601.1; -; Genomic_DNA.
DR   RefSeq; WP_012035946.1; NC_009464.1.
DR   AlphaFoldDB; Q0W4U2; -.
DR   STRING; 351160.RCIX1314; -.
DR   GeneID; 5145200; -.
DR   KEGG; rci:RCIX1314; -.
DR   eggNOG; arCOG00245; Archaea.
DR   OrthoDB; 24743at2157; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAJ36601.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000663}.
FT   DOMAIN          3..279
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   431 AA;  46446 MW;  776BF266F74A8558 CRC64;
     MPFKALVVGG AGDMGRWCSR LLKQSGFEVS ISSRRPDIMA IAESLGAGVA SVDYAGQFDV
     VVLSVPIDAI EGIAAQVGPR MKPGSLLMDL SSLKTGPVEA MLKYAPESVE VIGAHPLFGP
     GLETLEGRTI VLVPTGRSGR WLSVMRDVFE TAGAAVEIST PGEHDRKMAI VQGLTHFLYI
     SWGRAIQWMD VDLRDLEAYR TPVYGVTETM AGRVLAQNPE LYALIQSGHD VAPVRKAFIE
     ACTELAAMID AGDLETFKGT FSAAAAHYGD LEGAKERSER IVRLGQGELA AIKKSAGLER
     AFVLPGGRKV YGTVKELQRE DFTLETPSET LVLRYDAVSM LGPEGLSSLK DGSPSVGRDI
     LVKLPIGADV RVLGWVLTRI DGVTGVSHET RNAMGPDHVL YRLTVGVRPE RSEDTLQRVL
     ATIWGLGYEV K
//